Caga Strain of Helicobacter Pylori in Recurrent Aphtous Somatitis Patients Without Dyspeptic Symptoms: Response to Eradication Therapy

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dc.authorid0000-0003-0000-5568
dc.authorwosidErfan, Gamze/W-8139-2018
dc.contributor.authorErfan, Gamze
dc.contributor.authorMete, Rafet
dc.contributor.authorOran, Mustafa
dc.contributor.authorYanık, Mehmet Emin
dc.contributor.authorGüneş, Hayati
dc.contributor.authorKaya, Şule
dc.contributor.authorTopçu, Birol
dc.date.accessioned2022-05-11T14:09:55Z
dc.date.available2022-05-11T14:09:55Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractHelicobacter pylori (HP) play a role as an etiological factor of soine dermatological diseases such as rosacea and Behcet disease. Recurrent aphtus stomatitis (RAS) is the most common mucosal disease with unknown etiology. Several microbial agents such as HP also have been proposed as causative factors for this disease. Although some of the studies do not support a strong association between HP and RAS, the relationship might differ when the virulence of the infecting strains are examined. The cytotoxin-associated gene A (CagA) is one of the virulence factors of HP and has impact in some of the extra gastrointestinal dermatological diseases such as rosacea. In this study; the seroprevelance of CagA of non-dyspeptic RAS patients and the eradication treatment response in CagA positive and negative RAS patients were examined. In 87 RAS patients and 72 healthy volunteers; 43.6% of RAS patients and 25% of control subjects were CagA (+). The number of CagA (+) patients were significantly higher in RAS group. (OR: 3.61, 95%CI: 1.21-10.7, p=0.01). Out of 45 HP (+); 32 (80%) of patients who underwent eradication treatment assessed three months after treatment. In CagA (+) RAS patients; composite index score of RAS after eradication was significantly lower than before treatment (p 0.01) but in CagA (-) RAS patients statistical analysis revealed no difference (p= 0.11). The CagA strain of HP is significantly higher even in non-dyspeptic RAS patients than healthy cases. The eradication treatment in these patients with HP and CagA seropositivity improves symptoms of RAS.
dc.identifier.endpage289
dc.identifier.issn0393-6384
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84896833593
dc.identifier.scopusqualityN/A
dc.identifier.startpage285
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5204
dc.identifier.volume30
dc.identifier.wosWOS:000335937700047
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorErfan, Gamze
dc.institutionauthorMete, Rafet
dc.institutionauthorOran, Mustafa
dc.institutionauthorYanık, Mehmet Emin
dc.institutionauthorGüneş, Hayati
dc.institutionauthorKaya, Şule
dc.institutionauthorTopçu, Birol
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCag A
dc.subjecteradication treatment
dc.subjectHelicobacter Pylori
dc.subjectrecurrent aphtous stomatitis
dc.subjectAphthous Stomatitis
dc.subjectBehcets-Disease
dc.subjectInfection
dc.subjectAntigen
dc.subjectManifestations
dc.subjectImpact
dc.subjectUlcer
dc.subjectFacts
dc.titleCaga Strain of Helicobacter Pylori in Recurrent Aphtous Somatitis Patients Without Dyspeptic Symptoms: Response to Eradication Therapy
dc.typeArticle

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