Investigation of antiphospholipid antibody syndrome markers in the etiology of recurrent miscarriage

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dc.contributor.authorGörgülü, Vildan
dc.contributor.authorAktepe, Orhan Cem
dc.contributor.authorŞafak, Birol
dc.date.accessioned2022-05-11T14:42:08Z
dc.date.available2022-05-11T14:42:08Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractThis study aimed to determine the markers of antiphospholipid antibody syndrome (APS), which has an important place in the etiology of recurrent miscarriage, and toprovide guidance for the treatment of the related disorders. This prospective observational study was performed on 120 female patients admitted to the Obstetrics andGynecology outpatient clinics due to recurrent pregnancy loss. Blood samples were analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA) technique to findout the levels of APS-associated anticardiolipin (ACA), anti-beta2-glycoprotein I (a?2GPI), anti-annexin V (aANXV), anti-prothrombin (aPT), and antiphosphatidylserine(aPS) antibodies. A statistically significant difference was found between increased age groups and the number of miscarriages (p=0.03, p<0.05). There were no significantdifferences between the age groups by the time of miscarriage (p=0.35, p<0.05). ACA positivity (75%, n = 90) and anti-annexin V positivity (50.8%, n = 61) werehigher than the positive results found in other tests(p=0.01, p<0.05). Antiphospholipid antibodies (APAs) showed significantly different positivity levels by the age groups(p=0.01, p<0.05). The positivity levels of APAs were significantly different by the number of miscarriages (p=0.01, p<0.05). Other antibody levels were not statisticallysignificantly different. The frequency of positive APA levels increases with advancing age and a high number of miscarriages in association with the etiology of recurrentmiscarriage. Among the subgroups of these antibodies, ACA and anti-annexin V can serve as highly appropriate diagnostic markers in recurrent miscarriage.
dc.identifier.doi10.5455/medscience.2020.08.171
dc.identifier.endpage190
dc.identifier.issn2147-0634
dc.identifier.issn2147-0634
dc.identifier.issue1en_US
dc.identifier.startpage184
dc.identifier.trdizinidTkRJd01EazVPUT09
dc.identifier.urihttps://doi.org/10.5455/medscience.2020.08.171
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRJd01EazVPUT09
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9248
dc.identifier.volume10
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorŞafak, Birol
dc.language.isoen
dc.relation.ispartofMedicine Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleInvestigation of antiphospholipid antibody syndrome markers in the etiology of recurrent miscarriage
dc.typeArticle

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