Denosumab Experience in a Patient with End-Stage Renal Disease and Paget’s Disease of the Bone

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dc.contributor.authorBilen, Ogün İrem
dc.contributor.authorElbüken, Gülşah
dc.contributor.authorAğgül, Hünkar
dc.date.accessioned2023-05-06T17:23:33Z
dc.date.available2023-05-06T17:23:33Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractPaget’s disease of the bone (PDB) is a chronic bone disease which is characterized by accelerated bone turnover and disorganized bone remodeling. Diagnosis and treatment of PDB is particularly challenging in patients with chronic kidney disease (CKD). Denosumab administered subcutaneously at a single dose of 60 mg every 3 months reduced both serum total and bone-specific alkaline phosphatase (ALP) levels to near normal range in a 47-year-old male with CKD was suspected of having PDB due to very high serum total ALP levels and imaging findings suggestive of poliostotic involvement. Elevated serum total ALP levels detected at 3 months after denosumab suggests that serum total ALP starts to increase after 60 days of treatment but it is difficult to exactly determine the day when serum total ALP started to increase. It seems wise to administer denosumab at an interval of 60-120 days to maintain serum total ALP level within normal limits.
dc.identifier.doi10.5336/caserep.2021-86733
dc.identifier.endpage113
dc.identifier.issn2147-9291
dc.identifier.issue2en_US
dc.identifier.startpage110
dc.identifier.trdizinid529830
dc.identifier.urihttps://doi.org/10.5336/caserep.2021-86733
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/529830
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12143
dc.identifier.volume30
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBilen, Ogün İrem
dc.institutionauthorElbüken, Gülşah
dc.institutionauthorAğgül, Hünkar
dc.language.isoen
dc.relation.ispartofTürkiye Klinikleri Journal of Case Reports
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleDenosumab Experience in a Patient with End-Stage Renal Disease and Paget’s Disease of the Bone
dc.typeArticle

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