THE EFFECT OF VITAMIN-D ON THE DIABETIC RETHINOPATHY

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dc.contributor.authorErol, R. Selvinaz
dc.contributor.authorZuhur, Sayid Shafi
dc.contributor.authorÖztürk, F. Yener
dc.contributor.authorŞen, Esra Çil
dc.contributor.authorYıldız, Ayşegül Mavi
dc.contributor.authorCanat, M. Masum
dc.contributor.authorErol, M. Kazım
dc.date.accessioned2023-04-20T08:04:13Z
dc.date.available2023-04-20T08:04:13Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: To determine the relationship between grade of diabetic retinopathy and serum vitamin D levels in diabetic Methods: The study included a total of 173 diabetic patients consisting of patients without retinopathy ( n=67), patients with non proliferative diabetic retinopathy (NPDRP group n=47), patients with proliferative diabetic retinopathy (PDRP group n=59). Age and sex-matched 55 healthy subjects was taken as a control group. Patients with type 1 DM, those taking vitamin D, multivitamin including vitamin D, drug affecting vitamin D metabolism like rifampin, phenytoin was excluded from the study. Patients with chronic renal failure was also excluded. Dilated fundoscopic examination of all subject was done and serum creatinine, Hb A1c, 25 hydroxyvitamin D (25 (OH) D) level of all subject were measured between may 2012 and September 2012 Results: There were no statistical difference in age, sex, systolic tension, diastolic tension and body mass index between groups. Serum creatinine level was also not statistically different between groups (p = 0.11). Serum fasting glucose and HbA1c level were significantly lower in the control group than diabetic groups (p < 0.001). The mean 25 (OH)D levels of PDRP group, NPDRP group, diabetic patients without retinopathy and control group were 11,9 +/- 6,4 ng/ml, 18,8 +/- 10,2 ng/ml, 16,6 +/- 7,5 ng/ml and 20,1 +/- 9,2 ng/ml respectively. There was statistically significant difference between the PDRP group and other groups in univariate analysis (p < 0.001). When 173 diabetic patients, were compared, with control group, 25 (OH) D levels were significantly lower in diabetic patients than control group regardless of retinopathy status (p = 0.004). Conclusions: Diabetic patients especially, patients with proliferative diabetic retinopathy had lower serum vitamin D levels than healthy subjects. Additionally randomized, controlled, prospective studies are necessary to determine whether vitamin D treatment will stop or slow the progression of diabetic retinopathy in diabetic patients.
dc.identifier.doi10.19193/0393-6384_2022_1_60
dc.identifier.endpage376
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85124666043
dc.identifier.scopusqualityN/A
dc.identifier.startpage371
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2022_1_60
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11021
dc.identifier.volume38
dc.identifier.wosWOS:000792797700010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorZuhur, Sayid Shafi
dc.language.isoen
dc.publisherCarbone Editore
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetic Retinopathy
dc.subjectVitamin D
dc.subjectDiabetes Mellitus
dc.subjectProliferative Diabetic Retinopathy
dc.subject1-Alpha,25-Dihydroxyvitamin D-3
dc.subjectRetinopathy
dc.titleTHE EFFECT OF VITAMIN-D ON THE DIABETIC RETHINOPATHY
dc.typeArticle

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