Inflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss

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dc.authoridCALLIOGLU, NIHAL/0000-0002-4324-692X
dc.contributor.authorCallioglu, Nihal
dc.contributor.authorGul, Derya K.
dc.contributor.authorArslan, Ilke O.
dc.contributor.authorGeyikoglu, Ipek
dc.contributor.authorDemircivi, Erguel
dc.date.accessioned2024-10-29T17:58:54Z
dc.date.available2024-10-29T17:58:54Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjectives: To uncover the predictive value of systemic immune-inflammatory index (SII) and systemic inflammatory response index (SIRI) on early pregnancy loss. Methods: A total of 535 individuals were enrolled in this retrospective analysis. The early pregnancy losses (EPL) group included patients between 18-35 years old who experienced EPL. The control group comprised healthy pregnant women who gave birth at >= 37 weeks. Results: The EPL group had significantly lower plateletcrit (p=0.04), platelet distribution width (PDW, p<0.0001), and RDW (p<0.0001) and higher monocyte (p<0.0001) and SIRI (p<0.0001) values than the control group. The hemoglobin, white blood cells, platelet count, neutrophil count, lymphocyte count, mean platelet volume, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and SII values were not significantly different between the EPL and control groups (p>0.05). The cut-off value for the SIRI that offers the best sensitivity/specificity balance was 1.48 (sensitivity of 63%; specificity of 63%) in the receiver operating characteristics curve. Among the inflammatory parameters for predicting EPL, PDW had highest specificity (84%), and RDW had the highest sensitivity (80%). Conclusion: This study provides compelling evidence that various inflammatory pathways may significantly contribute to EPL pathogenesis. Moreover, our findings suggest that SIRI could be a more effective marker than NLR, PLR, MLR, and SII in predicting EPL in an ongoing pregnancy, thereby potentially revolutionizing early pregnancy loss diagnostics.
dc.description.sponsorshipAcknowledgment. The authors gratefully acknowledge enago ( www.enago.com ) , ulatus ( www.ulatus.com ) , and voxtab ( www.voxtab.com ) for their English language editing.
dc.identifier.doi10.15537/smj.2024.45.8.20240404
dc.identifier.endpage813
dc.identifier.issn0379-5284
dc.identifier.issn1658-3175
dc.identifier.issue8en_US
dc.identifier.pmid39074885
dc.identifier.scopus2-s2.0-85200101734
dc.identifier.scopusqualityQ3
dc.identifier.startpage808
dc.identifier.urihttps://doi.org/10.15537/smj.2024.45.8.20240404
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14550
dc.identifier.volume45
dc.identifier.wosWOS:001302049400006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSaudi Med J
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectearly pregnancy loss
dc.subjectsystemic immune- inflammatory index
dc.subjectsystemic inflammatory response index
dc.subjectsystemic immune- inflammatory index
dc.subjectsystemic inflammatory response index
dc.subjectmean platelet volume
dc.subjectinflammatory biomarkers
dc.titleInflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss
dc.typeArticle

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