Protective Effect of Nigella Sativa on Renal Reperfusion Injury in Rat

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dc.contributor.authorCaskurlu, Turhan
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorErboğa, Zeynep Fidanol
dc.contributor.authorÖzgül, Mustafa
dc.contributor.authorAtis, Gokhan
dc.date.accessioned2022-05-11T14:42:04Z
dc.date.available2022-05-11T14:42:04Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractIntroduction. This study was designed to investigate the effect of Nigella sativa (NS), in reperfusion-induced renal injury in rats. Materials and Methods. A total of 24 male Sprague-Dawley rats were divided into 3 groups of controls and rats that underwent ischemia-reperfusion with and without pretreatment with NS. A rat model of renal reperfusion injury was induced by 45-minute occlusion of the bilateral renal pedicles and 24-hour reperfusion. In the NS group, a single dose NS (400 mg/kg orally) was administered by gastric gavage. Results. Renal reperfusion caused severe histopathological injury such as tubular damage, atrophy dilatation, loss of brush border, and hydropic epithelial cell degenerations. Treatment with NS significantly attenuated the severity of reperfusion injury and significantly lowered tubulointerstitial damage score as compared with the reperfusion group. When kidney sections were stained with anti-proliferating-cell nuclear antigen antibody, nuclear factor kappaB p65 antibody, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling, there was a clear increase in the number of positive cells in the reperfusion group in the renal cortical tissues. However, there was a significant reduction in the number of stain-positive cells in kidney tissue from the NS group. Treatment of renal reperfusion injury with NS decreased the elevated tissue malondialdehyde levels and increased the reduced activities of the enzymatic antioxidants glutathione peroxidase and catalase. Conclusions. Pretreatment with NS has a protective effect against renal damage induced by renal reperfusion. This protective effect is possibly due to its ability to inhibit reperfusion-induced renal damage, apoptosis, and cell proliferation.
dc.identifier.endpage143
dc.identifier.issn1735-8582
dc.identifier.issn1735-8604
dc.identifier.issue3en_US
dc.identifier.pmid27225721
dc.identifier.scopus2-s2.0-84969506408
dc.identifier.scopusqualityQ3
dc.identifier.startpage135
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9194
dc.identifier.volume10
dc.identifier.wosWOS:000382833300006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorErboğa, Zeynep Fidanol
dc.language.isoen
dc.publisherIranian Soc Nephrolgy
dc.relation.ispartofIranian Journal of Kidney Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectreperfusion injury
dc.subjectkidney injury
dc.subjectproliferation
dc.subjectapoptosis
dc.subjectNigella sativa
dc.subjectrat
dc.subjectIschemia-Reperfusion
dc.subjectIschemia/Reperfusion Injury
dc.subjectOxidative Stress
dc.subjectApoptosis
dc.subjectDamage
dc.subjectExpression
dc.subjectOil
dc.subjectThymoquinone
dc.subjectConstituent
dc.subjectFailure
dc.titleProtective Effect of Nigella Sativa on Renal Reperfusion Injury in Rat
dc.typeArticle

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