Treatment of ventilator-associated pneumonia (VAP) caused by Acinetobacter: results of prospective and multicenter ID-IRI study

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dc.authorid0000-0002-4294-5999
dc.authorid0000-0003-0972-0461
dc.authorid0000-0003-1514-1685
dc.authorid0000-0002-6265-5227
dc.authorid0000-0002-6978-8671
dc.authorscopusid7005578733
dc.authorscopusid35764273000
dc.authorscopusid56035038600
dc.authorscopusid54685430400
dc.authorscopusid23035039800
dc.authorscopusid37040402000
dc.authorscopusid55062356800
dc.authorwosidErtan, Asli/AAE-6201-2021
dc.authorwosidInan, Asuman/D-5679-2014
dc.authorwosidsener, alper/F-6427-2011
dc.authorwosidUysal, Serhat/AAB-4876-2021
dc.authorwosidDagli, Ozgur/AAE-8749-2021
dc.authorwosidCag, Yasemin/S-7343-2016
dc.authorwosidersoz, gulden/A-4255-2018
dc.contributor.authorErdem, Hakan
dc.contributor.authorÇağ, Yasemin
dc.contributor.authorGencer, Serap
dc.contributor.authorUysal, Serhat
dc.contributor.authorKarakurt, Zuhal
dc.contributor.authorHarman, Rezan
dc.contributor.authorRello, Jordi
dc.contributor.authorDoğan, Mustafa
dc.date.accessioned2022-05-11T14:37:24Z
dc.date.available2022-05-11T14:37:24Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description.abstractVentilator-associated pneumonia (VAP) due to Acinetobacter spp. is one of the most common infections in the intensive care unit. Hence, we performed this prospective-observational multicenter study, and described the course and outcome of the disease. This study was performed in 24 centers between January 06, 2014, and December 02, 2016. The patients were evaluated at time of pneumonia diagnosis, when culture results were available, and at 72 h, at the 7th day, and finally at the 28th day of follow-up. Patients with coexistent infections were excluded and only those with a first VAP episode were enrolled. Logistic regression analysis was performed. A total of 177 patients were included; empiric antimicrobial therapy was appropriate (when the patient received at least one antibiotic that the infecting strain was ultimately shown to be susceptible) in only 69 (39%) patients. During the 28-day period, antibiotics were modified for side effects in 27 (15.2%) patients and renal dose adjustment was made in 38 (21.5%). Ultimately, 89 (50.3%) patients died. Predictors of mortality were creatinine level (OR, 1.84 (95% CI 1.279-2.657); p = 0.001), fever (OR, 0.663 (95% CI 0.454-0.967); p = 0.033), malignancy (OR, 7.095 (95% CI 2.142-23.500); p = 0.001), congestive heart failure (OR, 2.341 (95% CI 1.046-5.239); p = 0.038), appropriate empiric antimicrobial treatment (OR, 0.445 (95% CI 0.216-0.914); p = 0.027), and surgery in the last month (OR, 0.137 (95% CI 0.037-0.499); p = 0.003). Appropriate empiric antimicrobial treatment in VAP due to Acinetobacter spp. was associated with survival while renal injury and comorbid conditions increased mortality. Hence, early diagnosis and appropriate antibiotic therapy remain crucial to improve outcomes.
dc.identifier.doi10.1007/s10096-019-03691-z
dc.identifier.endpage52
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.issue1en_US
dc.identifier.pmid31502120
dc.identifier.scopus2-s2.0-85073948773
dc.identifier.scopusqualityQ1
dc.identifier.startpage45
dc.identifier.urihttps://doi.org/10.1007/s10096-019-03691-z
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8678
dc.identifier.volume39
dc.identifier.wosWOS:000511888500006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDoğan, Mustafa
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVentilator-associated pneumonia
dc.subjectVAP
dc.subjectPneumonia
dc.subjectAcinetobacter
dc.subjectMortality
dc.subjectTreatment
dc.subjectInfectious-Diseases Society
dc.subjectIntensive-Care Units
dc.subjectGuidelines
dc.subjectManagement
dc.subjectResistance
dc.subjectBaumannii
dc.subjectAmerica
dc.titleTreatment of ventilator-associated pneumonia (VAP) caused by Acinetobacter: results of prospective and multicenter ID-IRI study
dc.typeArticle

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