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    Effect of different latency periods on distraction osteogenesis in an experimental rabbit model Distraction osteogenesis and latent period
    (Bayrakol Medical Publisher, 2023) Kilic, Mehmet; Yurteri, Ahmet; Sokucu, Sami; Cetin, Mehmet Umit; Ozkan, Serbay; Cetin, Engin; Senturk, Gozde Erkanli
    Aim: This work used immunohistochemical and radiographic analysis to show how latency time affects distraction osteogenesis in animals. Material and Methods: Eighteen rabbits had right femur drill osteotomies and external fixators. Latency duration split the rabbits into three groups. Groups 1, 2, and 3 had latency times of 1, 5, and 10 days. After the latency period, all groups had a 20-day consolidation phase. After consolidation, the animals were euthanized, and immunohistochemical, histological, and radiological studies were performed on the distraction-induced callus tissue. Results: In radiological evaluation, there was no significant difference between Group 1 and Group 2 and Group 2 and Group 3 (p=1,000, p=0,066). Group 1 and 3 differed (p=0.018). Histopathological assessment showed no significant difference between Group 1 and Group 2 or Group 2 and Group 3 (p= 0,557, p=0,062). Group 1 and 3 differed (p=0,001). Group 3 had more osteocalcin-positive cells than Groups 1 and 2. Discussion: Histopathological and radiographic methods showed that a 10-day distraction osteogenesis latency time in rabbit femurs is safer than 1 and 5-day periods. Human distraction osteogenesis latency must be determined by clinical trials.
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    Femoral lengthening and deformity correction using the Fitbone motorized lengthening nail
    (Springer Japan Kk, 2015) Küçükkaya, Metin; Karakoyun, Özgür; Sokucu, Sami; Soydan, Ramazan
    This study reports our results with retrograde Fitbone insertion in patients with femoral shortening and deformity. We also present our experience regarding the benefits, complications, and factors associated with complications of the Fitbone technique. Twelve males and ten females had femoral shortening and deformities treated using the retrograde Fitbone technique between 2009 and 2012. The etiologies were post-traumatic in 12 patients, poliomyelitis in four, cosmetic in two, congenital hypoplasia in two, achondroplasia in one, and Perthes sequela in one. The follow-up time was 30.8 months. The mean lengthening was 5.8 (range 2-14) cm. The degree of acute angular correction was 9A degrees (5-22A degrees) in nine cases. The time to full weight-bearing was 5.9 months. The consolidation index was 1.07 (0.75-1.62) months/cm. Complete consolidation was obtained in all cases except two. Running back was observed in two cases. The Fitbone technique allows accurate deformity correction. The rigid reamers allow the surgeon to use the Fitbone even in patients with a narrow medullary canal. As this might result in poor bone regeneration, thinner lengthening nails should be considered.
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    Intramedullary skeletal kinetic distractor in lower extremity lengthening
    (Turkish Assoc Orthopaedics Traumatology, 2014) Karakoyun, Özgür; Küçükkaya, Metin; Sokucu, Sami
    [No Abstract Available]
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    Use of a magnetic bone nail for lengthening of the femur and tibia
    (Hong Kong Acad Medicine Press, 2016) Karakoyun, Özgür; Sokucu, Sami; Erol, Mehmet Fatih; Küçükkaya, Metin; Kabukcuoglu, Yavuz Selim
    Purpose. To report our experience with the PRECICE nail for limb lengthening in 23 patients. Methods. Records of 15 female and 8 male patients aged 14 to 38 (mean, 23.6) years who underwent lengthening of the tibia (n=6) or femur (n=21) using the PRECICE nail were reviewed. The reasons for lengthening included trauma (n=7), hemihypertrophy (n=2), focal femoral deficiency (n=2), Ellis-van Creveld syndrome (n=1), hip septic arthritis sequelae (n=1), hereditary multiple exostosis (n=1), club foot sequela (n=1), congenital tibial pseudoarthrosis (n=1), fibrous dysplasia (n=1), idiopathic limb length discrepancy (n=7), and cosmetic (n=1). Results. The mean follow-up duration was 20.72 months. The mean lengthening was 48.20 mm, and the mean acute angular correction was 15.5 degrees. The mean time to full weight-bearing was 5.15 months, and the mean consolidation index was 1.12 months / cm. The mean maturation index was 0.78 months / cm. One patient had nail breakage during the consolidation phase. The nail was replaced by an intramedullary nail until consolidation, after which another PRECICE nail was used to treat the residual shortening. Eight patients had over-lengthening and the nails were driven back to the desired length. No patient had infection. Conclusion. The PRECICE nail is a viable option for lengthening of the femur and tibia.