Effect of different latency periods on distraction osteogenesis in an experimental rabbit model Distraction osteogenesis and latent period
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bayrakol Medical Publisher
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: This work used immunohistochemical and radiographic analysis to show how latency time affects distraction osteogenesis in animals. Material and Methods: Eighteen rabbits had right femur drill osteotomies and external fixators. Latency duration split the rabbits into three groups. Groups 1, 2, and 3 had latency times of 1, 5, and 10 days. After the latency period, all groups had a 20-day consolidation phase. After consolidation, the animals were euthanized, and immunohistochemical, histological, and radiological studies were performed on the distraction-induced callus tissue. Results: In radiological evaluation, there was no significant difference between Group 1 and Group 2 and Group 2 and Group 3 (p=1,000, p=0,066). Group 1 and 3 differed (p=0.018). Histopathological assessment showed no significant difference between Group 1 and Group 2 or Group 2 and Group 3 (p= 0,557, p=0,062). Group 1 and 3 differed (p=0,001). Group 3 had more osteocalcin-positive cells than Groups 1 and 2. Discussion: Histopathological and radiographic methods showed that a 10-day distraction osteogenesis latency time in rabbit femurs is safer than 1 and 5-day periods. Human distraction osteogenesis latency must be determined by clinical trials.
Açıklama
Anahtar Kelimeler
Distraction Osteogenesis, Latency Period, Osteotomy, Rabbit Model
Kaynak
Annals of Clinical and Analytical Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
14
