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Öğe Altered Affective Temperaments in Women With Vaginismus(NLM (Medline), 2021) Aksu, Erson; Beyazyüz, Elmas; Albayrak, Yakup; Potas, Nihan; Kumandaş, Gökçen; Bağ, İdil; Beyazyüz, MuratOBJECTIVE: Vaginismus is one of the most frequently occurring genito-pelvic pain disorders in women. Sexual dysfunction commonly presents with comorbid psychiatric disorders, and many patients suffering from the former exhibit the latter. The objective of this study was to investigate the affective temperaments of women with vaginismus compared to healthy controls. METHODS: Forty-eight women with vaginismus and 42 age-matched healthy women were recruited and compared in terms of their scores on the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire and a sociodemographic instrument. RESULTS: Except for the scores for hyperthymic temperament, those for depressive, cyclothymic, irritable, and anxious temperaments were significantly higher in the vaginismus group than in the healthy controls (P<.05). The analysis of covariance indicated that the anxious temperament was significantly associated with covariants. CONCLUSIONS: On the basis of the preliminary results, women with vaginismus may be candidates for bipolar disorder. This population should therefore be screened more carefully in terms of the development of the disorder. Bipolar disorder should also be considered when treatments for comorbid psychiatric disorders are needed. © Copyright 2021 Physicians Postgraduate Press, Inc.Öğe Altered cooperativeness in patients with polycystic ovary syndrome(Taylor and Francis Ltd., 2019) Aksu, Erson; Beyazyüz, Elmas; Albayrak, Yakup; Potas, Nihan; Durankuş, Ferit; Uvaçin, Gamze; Beyazyüz, MuratOBJECTIVE: In the present study, we aimed to compare temperament and character traits between patients with polycystic ovary syndrome (PCOS) and age-body mass index-matched healthy controls (HC). We hypothesized that patient with PCOS would differ in terms of temperament and character traits compared with HCs. MATERIAL AND METHODS: Fifty patients who were diagnosed with PCOS and 42 age-body mass index-matched healthy controls (HC) were included in the study. The groups were compared in terms of temperament and character traits and anxiety status with the Temperament and Character Inventory (TCI) and State-Trait Anxiety Inventory (STAI-1 and STAI-2). FINDINGS: There was a statistically significant difference between patient and the control group in terms of cooperativeness dimension (t = ?2.81; p = 0.006). It was a lower mean in the PCOS group (20.98 ± 2.992). In addition, scores of STAI-1 and STAI-2 were significantly higher in the PCOS group compared with the HC group (respectively; t = 5.70; p < 0.001; t = 2.12; p = 0.037). The score of cooperativeness and multivariate analysis of variance was found to be significantly lower in the PCOS group. CONCLUSIONS: Patients with PCOS had significant a different character trait such as lower cooperativeness compared with HC. Additionally, we found that this different character dimension would be a trait in PCOS after covariant analysis. We suggest that our result supported the psychiatric background of PCOS. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Öğe Altered methyltetrahydrofolate reductase gene polymorphism in mothers of children with attention deficit and hyperactivity disorder(Pergamon-Elsevier Science Ltd, 2019) Baykal, Saliha; Batar, Bahadır; Nalbantoğlu, Ayşin; Albayrak, Yakup; Hanci, Halil; Potas, Nihan; Karabekiroğlu, KorayAttention Deficit and Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders in childhood and causes significant functional impairments in children. Behavioral genetic and molecular genetic studies have provided significant evidence in terms of highlighting the etiology of ADHD. Folate deficiency during pregnancy is an established risk factor for ADHD. Polymorphisms in the Methyltetrahydrofolate Reductase (MTHFR) encoding gene, such as A1298C and C667T, are associated with the decreased bioavailability of folate, and this condition can act like folate deficiency. In the literature, no study has investigated MTHFR polymorphisms in mothers of children with ADHD. Sixty-four children diagnosed with ADHD and their mothers as well as 40 healthy children and their mothers participated in this study. MTHFR polymorphisms were investigated in all participants. Comparison of the C677C and A1298C MTHFR polymorphisms in children with and without ADHD revealed no significant differences. We found that the maternal C677C_CT genotype counts, both observed and expected values, were significantly different from those based on Hardy-Weinberg Principle Analysis in the ADHD group. The most important result of this study was that maternal C677C MTHFR gene polymorphisms are significant risk factors in for ADHD, and we argue that children with ADHD are exposed to folate deficiency, even if their mothers received a sufficient amount of folate during pregnancy. This result also highlights one of the genetic factors of ADHD. Further studies should be performed to confirm this finding.Öğe Altered Serum Chitotriosidase Activity and Irisin Level in Obese Children(2021) Durankus, Ferit; Şenkal, Evrim; Durankuş, Ramazan; Sünnetçi, Eda; Sayın, Oya; Potas, Nihan; Albayrak, YakupObjective:In this study, we aimed to investigate serum chitotriosidase (ChT) activity and irisin levels in children with obesity and compare them to those of healthy counterparts. Material and Methods: A total of 91 obese and 83 normal-weight children were included in the study. Serum ChT activity and irisin levels of children with obesity were compared to those of normal-weight children. Results: The mean ChT value in the obese group was 1825.332 ± 4804.147 nmol/L/h and was significantly higher than that in the control group. In contrast, the mean irisin level, 2679.663 ± 5473.58 pg/ml, was lower than that in the control group. The cutoff point of the continuous variable selected in the model for ChT was 601, with 31.9% sensitivity, 90.6% specificity, and an area under the curve of 0.596. The cutoff point for irisin was 901.4, with 83.5% sensitivity, 42.4% specificity, and an area under the curve of 0.617. Conclusion: This study is the first to show decreased serum both serum ChT activity and irisin level and ChT’s association with irisin levels in children with obesity . We argue that ChT and irisin should be considered potential biomarkers of metabolic syndrome in children with obesity.Öğe Altered thiol/disulfide homeostasis and ischemia-modified albumin levels in children with irritable bowel syndrome(John Wiley and Sons Inc, 2021) Durankuş, Ferit; Şenkal, E.; Çam, Sebahat; Potas, Nihan; Albayrak, Yakup; Nural, C.; Erel, ÖzcanBackground: In this study, we assessed thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with irritable bowel syndrome (IBS) compared with healthy children. Methods: Fifty-six children with IBS and 53 healthy children were included in the study after assessment of inclusion and exclusion criteria. Plasma thiol/disulfide and IMA levels were compared between children with and without IBS. Results: The mean values of native thiol, total thiol, and disulfide were 343.779 (Formula presented.) 138.654 ?mol/L, 365.398 ± 140.148 ?mol/L, and 23.190 ± 4.978 ?mol/L, respectively, in the IBS group and 409.908 ± 69.288 ?mol/L, 433.481 ± 76.891 ?mol/L, and 20.090 ± 4.252 ?mol/L, respectively, in the control group. Native thiol and total thiol values were significantly reduced in the IBS group compared with the control group. The mean IMA values were 0.835 ± 0.083 (g/L) and 0.778 ± 0.072 in the IBS and control groups, respectively. The IMA value was significantly increased in the IBS group. Conclusion: Impaired thiol/disulfide homeostasis and increased IMA levels can be considered etiological factors in children with IBS. © 2020 Japan Pediatric SocietyÖğe Decreased serum orexin A levels in drug-naive children with attention deficit and hyperactivity disorder(Springer-Verlag Italia s.r.l., 2019) Baykal, S.; Albayrak, Yakup; Durankuş, Ferit; Güzel, S.; Abbak, Özlem; Potas, Nihan; Donma, Mustafa MetinAttention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders of childhood and characterized by inattention, hyperactivity, and impulsivity. ADHD is a neurodevelopmental disorder, and its etiology has not yet been determined precisely. Orexin A is thought to play an important role in different forms of learning, memory, and attention. Despite its importance in attention and learning, no study has investigated serum orexin levels in patients with ADHD. In the present study, we aimed to compare serum orexigenic neuropeptides such as orexin A and orexin B, neuropeptide Y, and ghrelin between drug naive children with ADHD and healthy children. Fifty-six drug-naive children with ADHD and 40 healthy controls were enrolled in the study. After comparison of serum orexin A and orexin B, neuropeptide Y, and ghrelin, we found that serum orexin A levels were significantly lower in the ADHD group (p = 0.001). Furthermore, serum orexin A levels were compared between ADHD subgroups. Orexin A levels were significantly lower in the inattentive subtype compared with the hyperactive subtype and combined subtype (p = 0.009). Our results indicate that orexin A might be a neurobiological etiological factor in ADHD, particularly associated with attention symptoms. The present study is the first to demonstrate decreased serum orexin A levels in drug-naive children with ADHD. Further studies are needed to confirm our results and to show the effects of treatments involving orexin A in patients with ADHD. © 2019, Fondazione Società Italiana di Neurologia.Öğe Distinct temperament and character traits in patients with hyperemesis gravidarum(Taylor & Francis Ltd, 2020) Aksu, Erson; Albayrak, Yakup; Beyazyüz, Elmas; Potas, Nihan; Durankuş, Ferit; Tenel, Burçak; Beyazyüz, MuratHyperemesis gravidarum (HG) is an extreme form of vomiting during pregnancy and is characterized with excessive vomiting and nausea and ketonuria, electrolyte imbalance, dehydration and severe nurtition deficiency. The etiology of HG is considered as multifactorial. Altough there is a great interest to HG in terms of psychiatric conditions, there have been limited numbers of studies that researched personality traits in patients with HG. In present study, we aimed to compare temperament and character traits between pregnant women with and without HG by Temperament and Character Inventory. 48 pregnant women with HG and 64 healthy pregnant women were included to study. The HG groups and control group were compared in terms of temperament and character traits and anxiety levels. The temperament scores of novelty seeking, harm avoidance and reward dependence were found to be similar between groups while the score of persistence was significantly lower in HG group compared with control group (p = .021). All character scores in HG group as cooperativeness, self-directedness, and self-transcendence were significantly lower compared with control groups (respectively;p = .002,p = .018 andp = .029). The scores of STAI-1 was higher in HG group compared with control group (p = .027) whereas the score of STAI-2 was found to be similar between groups. Present study is the first to demonstrate different temperament and character traits in patients with HG. We argue that our results support the psychiatric background of HG; however further studies are needed to confirm our results.Öğe Increased Levels of Anxiety, Depression, and Secondary Trauma in Radiation Oncologists during COVID-19 Pandemic: A Preliminary Report from Turkey(Kare Publ, 2021) Durankuş, Nulifer Kilic; Bölükbaşı, Yasemin; Albayrak, Yakup; Potas, Nihan; Sezen, Duygu; Akdemir, Eyub Yaşar; Selek, UgurOBJECTIVE We surveyed the anxiety, depression, and secondary trauma levels of Turkish Radiation Oncologists related with COVID pandemics. METHODS An anonymous online questionnaire survey was created to evaluate levels of depression, anxiety, and secondary trauma among Turkish Radiation Oncologists. The survey included demographics and occupational status, Secondary Traumatic Stress Scale (STSSS), The Beck Depression Inventory (BDI), The Beck Anxiety Inventory (BAI), and State-Trait Anxiety Inventory (STAI). RESULTS Seventy-two respondents provided the power of about 91.4% for the significance level of 0.05. The variance homogeneity was checked by the Levene test, the effect of COVID-19 on psychology is higher in the group of >19 (9.02 +/- 0.820), as well as the effect of social isolation (8.02 +/- 1.622), the STSS scores (34.28 +/- 9.062), the STAIS scores (60.46 +/- 5.296), the STAIT scores (82.21 +/- 9.298), the BDI scores (22.68 +/- 2.788), and the BAI scores (21.04 +/- 9.321). The multiple regressions to estimate BDI revealed statistically significant effects in STAIS, BAI, and STAIT. There is a significant correlation between STSS, STAIS, STAIT, BDI, BAI, the effect of COVID-19 on psychology, and the effect of social isolation. CONCLUSION We have established one of the first studies demonstrating the effects of COVID-19 pandemic on depression, anxiety levels, and secondary trauma on a special physician population, the Radiation Oncologists, who specifically do not directly take part in COVID19 management.Öğe Increased serum BDNF and ProBDNF levels in children with irritable bowel syndrome(Elsevier Inc., 2020) Şenkal, Evrim; Durankuş, Ferit; Çam, Sebahat; Potas, Nihan; Beyazyüz, Murat; Albayrak, YakupObjective: Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders among the pediatric population. Recently, neurotrophins have been suggested to be etiological factors or causes of symptoms of IBS. In the present study, the aim was to research the serum brain-derived neurotrophic factor (BDNF) and proBDNF levels in children with IBS. Methods: The study group was selected from pediatric gastroenterology outpatient clinic and control group was recruited from healthy children outpatient clinic. Based on the inclusion and exclusion criteria, 29 children with IBS and 55 healthy children were included in the study. The data were obtained from all participants, and if needed, from their parents. All participants were assessed in terms of anthropometric measurements. The serum (BDNF) and proBDNF levels were compared between the groups. Results: The proBDNF levels in IBS patients were higher compared with the control group in covariance analysis (IBS patients group mean 492.4, SD 534.1; control group mean 332.8, SD 406.7) (p = 0.02; Cohen's d = 0.45). The serum BDNF levels of IBS patients were also higher compared with the control group (IBS patients group mean 3.1, SD 4.3; control group mean 1.7, SD 2.7) (p = 0.02; Cohen's d = 0.51). Conclusions: The present study is the first to demonstrate that there is a higher level of serum BDNF in children with IBS. Moreover, it is the first to demonstrate an increased level of proBDNF in IBS. Additional research is needed to confirm the preliminary results. © 2020 Elsevier Inc.Öğe İrritabl Barsak Sendromlu Hastalarda Patolojik Endişe ve Üst-bilişsel İnançların İncelenmesi(Istanbul Universitesi, 2016) Akyol, Esra Soydaş; Şahin, Başak; Beyazyüz, Murat; Gökmen, Esra; Erbağ, Gökhan; Potas, NihanÖZET Amaç: İrritabl Barsak Sendromu toplumun yaklaşık %20’sini etkileyen fonksiyonel bir gastrointestinal hastalıktır. İrritabl Barsak Sendromu psikiyatrik belirtilerle yakından ilişkilidir. Bu çalışmada İrritabl Barsak Sendromu olan hastaların patolojik endişe düzeylerini ve üst-bilişsel inançlarını sağlıklı kontrol grubu ile karşılaştırmayı amaçladık. Yöntem: İrritabl Barsak Sendromlu 63 hasta ve yaş ve cinsiyet uyumlu 55 sağlıklı gönüllü çalışmaya dâhil edildi. İrritabl Barsak Sendromu grubu ve sağlıklı kontrol grubu Penn State Endişe Ölçeği vasıtası ile patolojik endişe yönünden ve Üst-biliş Ölçeği 30 vasıtası ile üst-bilişsel inançlar açısından karşılaştırıldı. Bulgular: İrritabl Barsak Sendromlu hastalar Penn State Endişe Ölçeği’nde sağlıklı kontrollere göre daha yüksek skora sahipti (t=2.69, p=0.008). Olumlu inançlar alt skoru İrritabl Barsak Sendrom grubunda kontrol grubuna göre daha yüksek olarak bulundu (t=2.16, p=0.03). Üst-biliş Ölçeği toplam skoru ve diğer alt skorlar gruplar arasında benzer olarak saptandı. Sonuçlar: Çalışmamızın sonuçları İrritabl Barsak Sendromlu hastaların psikiyatrik bozukluklara daha meyilli olduğunu ve farkındalık terapilerinden fayda görebileceklerini düşündürtmektedir. Bu konuyu aydınlatacak daha ileri araştırmalara ve takip çalışmalarına ihtiyaç bulunmaktadır.Öğe Reliability properties of systems with three dependent components(Springer, 2015) Yılmaz, Mehmet; Potas, Nihan; Topçu, BirolThis study aims to investigate the reliability properties of the systems constituted of three identical components that are dependent of each other. Besides this, it is studied to compare between the lifetimes of such systems in the sense of hazard rate ordering. Illustrative examples are given by considering some trivariate exponential distributions that are commonly used in reliability literature for the joint distribution of the component lifetimes. © Springer International Publishing Switzerland 2015.
