Yazar "Ozturk, Ibrahim I." seçeneğine göre listele

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    Establishing Composition of Solid Solution Based on Single Crystal and Powder X-ray Measurement: The Case of Halogenated Bismuth(III) Complexes with Acetophenone-4-methyl-3-thiosemicarbazone
    (Mdpi, 2024) Grzeskiewicz, Anita M.; Dutkiewicz, Grzegorz; Ozturk, Ibrahim I.; Kubicki, Maciej
    New bismuth (III) complexes with acetophenone-4-methyl-3-thiosemicarbazone (L) and halogens (Cl and Br) in both bridging and terminal positions have been synthesized and structurally characterized using single-crystal X-ray diffraction. The pure complexes (Cl or Br) were found to be highly isostructural, which motivated our attempts to create solid solutions of these complexes. A series of such compounds was prepared using various procedures and stoichiometries. A method for determining the mutual concentrations of different halogens, based on the positions of selected peaks in powder diffraction patterns, was tested and compared with other methods.
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    Group VA Aromatic Thiosemicarbazone Complexes: Synthesis, Characterization, Biological Activity, and Topological Studies
    (Mdpi, 2024) Ozturk, Ibrahim I.; Sumer, Emine I.; Dutkiewicz, Grzegorz; Banti, Christina N.; Hadjikakou, Sotiris K.; Grzeskiewicz, Anita M.; Kubicki, Maciej
    The antiproliferative and antibacterial activities of thiosemicarbazones increase markedly with the presence of metal ions. One of the factors determining the activity of metal thiosemicarbazone complexes is the coordination structure. In this study, the biological effects of new antimony (III) and bismuth (III) thiosemicarbazone complexes with different binding modes and geometrical structures were demonstrated. Three new complexes, with the formulae {[SbCl3(mu 2-S-Hacptsc)(eta 1-S-Hacptsc)], 2/3H2O,1/3CH2Cl2}, {[SbCl3(kappa 2-S,N-Hacpmtsc)(eta 1-S-Hacpmtsc)2CH2Cl2]}, and{[BiCl3(eta 1-S-Hbzmtsc)3]C2H5OH}, where Hacptsc: acetophenone thiosemicarbazone, Hacpmtsc: acetophenone-N-methyl thiosemicarbazone, Hbzmtsc: benzaldehyde-N-methyl thiosemicarbazone) were elucidated by different methods and deeply analyzed in accordance with their structure by X-ray structure analysis and Atoms-In-Molecules topological analysis. This analysis provided a deeper understanding of the coordination spheres of the Sb/Bi complexes. For instance, the first reported two binding modes of the same ligand are observed in a single crystal structure of antimony (III) halide complexes. Additionally, in one of the complexes, a solid-to-solid phase transition was detected and analyzed in detail. Those complexes, very unique in terms of their geometry, have also been tested for their in vitro cytotoxic activity against human adenocarcinoma cervical cancer (HeLa) cells, whereas antimony (III) complex 1is the most active complex of this study. Further, the antibacterial activity of the complexes has been screened against two Gram-negative (Pseudomonas aeruginosa and Escherichia coli) and two Gram-positive (Staphylococcus epidermidis and Staphylococcus aureus) pathogenic bacteria. From the results, it is found that all the complexes exhibited significant activity against the Gram-negative pathogenic bacteria.
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    Heteroleptic six-coordinate bismuth(iii) complexes with 2-acetylthiophene thiosemicarbazones: synthesis, characterization, and biological properties
    (Royal Soc Chemistry, 2023) Ozturk, Ibrahim I.; Turk, Kadriye; Grzeskiewicz, Anita M.; Kubicki, Maciej; Banti, Christina N.; Hadjikakou, Sotiris K.
    The present study aimed to prepare and then evaluate the antiproliferative and antibacterial activities of bismuth(III) thiosemicarbazone complexes. Five bismuth(III) halide complexes of general formulae [BiX3(HL)(3)] (X: Cl; 1 and 2) and [BiX2(mu(2)-X)(HL)(2)](2) (X: Br and I; 3,4 and 5), where HL is a thiosemicarbazone bearing an acetylthiophene moiety, have been synthesized and fully characterized, including their X-ray crystal structures. In all cases, the thiosemicarbazone ligand coordinated in a monodentate mode via the sulfur atom. Complexes 1 and 2 are mononuclear bismuth(III) complexes with octahedral (Oh) geometry around the metal ion formed by three sulfur and three chlorine atoms. However, the coordination mode of the ligands varied around the bismuth centers. Complex 1 contains one molecule with only a meridional orientation in its asymmetric unit, while complex 2 contains two molecules in its asymmetric unit, one with meridional orientation and the other with facial one. Two bismuth(III) atoms in dinuclear complexes (3, 4 and 5) were coordinated with each other by two halogen bridges. The bismuth(III) complexes 1-5 and their free ligands have been tested for their in vitro cytotoxic activity against human adenocarcinoma cervical cancer (HeLa) cells. The complexes showed promising results as antiproliferative agents for the HeLa cell line, with IC50 values ranging from 4.5 +/- 0.4 to 24.3 +/- 1.7 mu M. All these complexes were also tested against a series of bacteria, and they proved to be ineffective against Gram-positive bacteria (S. epidermidis and S. aureus) and moderately active against Gram-negative bacteria (P. aeruginosa and E. coli).
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    Solid-to-solid phase transitions in two isostructural Bi(III) complexes and their solid solution.
    (Int Union Crystallography, 2024) Grzeskiewicz, Anita M.; Dutkiewicz, Grzegorz; Aygun, Ozlem; Ozturk, Ibrahim I.; Kubicki, Maciej
    [No abstract available]
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    Solid-to-solid polymorphic phase transitions in two isostructural Bi(III) complexes with 1-phenylethyl-N-ethylthiosemicarbazide and halogens
    (Nature Portfolio, 2023) Grzeskiewicz, Anita M.; Dutkiewicz, Grzegorz; Aygun, Ozlem; Ozturk, Ibrahim I.; Kubicki, Maciej
    Two isostructural (in room temperature) complexes of Bi(III) with halogens and sulfur ligands have been investigated in terms of the solid-to-solid phase transitions indicated by temperature. Both chloride and bromide (X) complexes of the general formula (& mu;(2)-X)-(BiX2L2)(2) exhibit some phase transitions between 100 and 333 K, which, apart from the numerous similarities, show significant differences, which have been noted and analyzed in detail in this paper by using different techniques, i.e., powder and single crystal diffraction or DSC. The obtained results have also been collated with those obtained for solid solutions of both complexes.
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    SYNTHESIS, CHARACTERIZATION AND HIRSHFELD SURFACE ANALYSIS OF SOME THIOSEMICARBAZONES CONTAINING A FIVE-MEMBERED RING
    (Pleiades Publishing Inc, 2023) Ozturk, Ibrahim I.
    Thiosemicarbazones, which are multidentate ligands, are considered as one of the most important classes of organic compounds due to their broad spectrum of pharmacological effects and their ability to coordinate easily with metal ions. Four thiosemicarbazones, furan-2-carbaldehyde-N-methyl thiosemicarbazone (Hfmtsc), thiophene-2-acetaldehyde thiosemicarbazone (Hattsc), thiophene-2-acetaldehyde-N-methyl thiosemicarbazone (Hatmtsc) and thiophene-2-acetaldehyde-N-ethyl thiosemicarbazone (Hatetsc) were successfully prepared via condensation reaction using substituted aldehyde and (un)substituted thiosemicarbazides. They were characterized by melting point, elemental analysis, molar conductivity, FTIR, UV-Vis, H-1 and C-13 NMR spectroscopic techniques. The crystal structure of them was determined by using single crystal X-ray diffraction study. Intermolecular interactions were investigated by Hirshfeld surface analysis. Molecular structure of compounds was stabilized by N-H center dot center dot center dot S, C-H center dot center dot center dot S, N-H center dot center dot center dot O and C-H center dot center dot center dot O interactions. In each compound, the molecules are connected into R-2(2)(8) dimers via pairs of N-H center dot center dot center dot S interactions.
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    Synthesis, Characterization, and Biological Investigation of Antimony(III) Halide Complexes With Different Coordination Architectures Constructed From Thiophene Thiosemicarbazones
    (Wiley, 2025) Ucar, Okan; Ozturk, Ibrahim I.; Grzeskiewicz, Anita M.; Kubicki, Maciej; Banti, Christina N.; Hadjikakou, Sotiris K.
    In this study, we report the synthesis, characterization, and biological investigation of antimony(III) halide complexes with various coordination architectures constructed from thiophene thiosemicarbazones. Antimony(III) thiophene-2-carbaldehyde thiosemicarbazone complexes (1, 2, 4, and 5) exhibit a square pyramidal geometry, with ligands coordinated to the central antimony atom in two distinct binding modes. In contrast, antimony(III) 2-acetylthiophene thiosemicarbazone complexes (3, 6, and 7) adopt a seesaw geometry. These complexes (1-7) represent the first reported examples of antimony(III) halide thiosemicarbazone compounds. The unique coordination environments observed in these complexes are of significant importance within the realm of antimony chemistry. These synthesized complexes exhibit different coordination geometries as well as potential biological activities. The antiproliferative activity against the human breast adenocarcinoma (MCF-7) cell line and antimicrobial activity against Gram-positive and Gram-negative bacteria were assessed. Antimony(III) thiophene-2-carbaldehyde thiosemicarbazone complexes (1, 2, 4, and 5) showed significant antiproliferative activity with IC50 values ranging from 8.5 to 19.1 mu M, while antimony(III) 2-acetylthiophene thiosemicarbazone complexes (3, 6, and 7) had higher IC50 values. Additionally, the antimony complexes demonstrated selective antimicrobial activity against Gram-negative bacteria.
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    Synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes with uncommon geometries
    (Elsevier Science Sa, 2025) Ucar, Okan; Ozturk, Ibrahim I.; Grzeskiewicz, Anita M.; Kubicki, Maciej; Banti, Christina; Hadjikakou, Sotiris K.
    The synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes containing thiophene-derived ligands are reported. Two complexes were synthesized: {[SbBr2(kappa 2-N3, S-Hatetsc)]} (1) and {[SbCl2(eta 1-S-Hatmtsc)(kappa 2-N3,S-Hatmtsc)]} (2). X-ray crystallography revealed complex 1 adopts a distorted seesaw structure, while complex 2 has a distorted square pyramidal structure. Both complexes showed significant antiproliferative activity against HeLa cancer cells. They also exhibited enhanced antibacterial activity against Gram-negative bacteria, particularly Escherichia coli. This study highlights the potential of thiophene-based antimony(III) complexes as promising candidates for anticancer and antibacterial therapies.