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  • Küçük Resim
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    Comparison of Ovulation Induction Protocols After Endometrioma Resection
    (Soc Laparoendoscopic Surgeons, 2014) Bastu, Ercan; Yasa, Cenk; Dural, Özlem; Mutlu, Mehmet Firat; Çelik, Cem; Uğurlucan, Funda Güngör; Buyru, Faruk
    Background and Objectives: The aim of this study was to compare the in vitro fertilization (IVF) outcomes of long gonadotropin-releasing hormone agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) protocols in endometriosis patients who have undergone laparoscopic endometrioma resection surgery. To our knowledge, there is no study in the current literature that compares the effectiveness of long GnRH-a and GnRH-ant protocols in management of IVF cycles in endometriosis patients who underwent laparoscopic endometrioma resection surgery. Methods: Eighty-six patients with stage III to IV endometriosis who had undergone laparoscopic resection surgery for endometrioma were divided into 2 groups: those who had ovarian stimulation with a long GnRH-a protocol (n = 44), and those who had ovarian stimulation with a GnRHant protocol (n = 42). Results: The number of follicles on human chorionic gonadotropin injection day, duration of hyperstimulation, number of retrieved metaphase II oocytes, and total number of grade 1 embryos were statically significantly higher in the long GnRH-a protocol. There were no significant differences in positive beta-human chorionic gonadotropin pregnancy rates (25% vs 21.4%; P = .269) and ongoing pregnancy rates per patient (20.5% vs 19.1%; P = .302) between the 2 protocols. Conclusions: Long GnRH-a and GnRH-ant protocols both present similar IVF outcomes in patients with endometriosis who have undergone laparoscopic endometrioma resection surgery. A long GnRH-a protocol may lead to a higher number of embryos that can be cryopreserved, providing the possibility of additional embryo transfers without having to go through the process of ovarian stimulation again.
  • Küçük Resim
    Öğe
    Ovarian Volume in Turkish Women with Normal and Polycystic Ovaries
    (Derman Medical Publ, 2014) Çelik, Cem; Abalı, Remzi; Nalbanto?lu, Burçin; Taşdemir, Nicel; Bastu, Ercan; Mutlu, Mehmet Firat
    Aim: We aimed to investigate possibility of different ovarian volume threshold and to study diagnostic thresholds for polycystic ovary in Turkish women, since the literature on this subject is very limited. Material and Method: Clinical study carried out Namik Kemal University School of Medicine, Tekirdag, Turkey. This case-control study included 132 patients with polycystic ovary syndrome (PCOS), diagnosed according to Rotterdam criteria and 75 controls. Comparison of ovarian volumes between PCOS patients and control group. Results: We found a mean ovarian volume of 9.44 +/- 4.3 cm3 in PCOS cases and 7.63 +/- 3.66 cm3 in control cases. The area under curve (AUC) for mean ovarian volume (MOV) was 0.633. The analysis showed that setting the threshold of MOV at 8.2 cm3 offered the best compromise between specificity (61.3%) and sensitivity (53.8%). Discussion: Optimum threshold of ovarian volume to distinguish the PCOS from normal women and the mean ovarian volume in Turkish PCOS patients remain beneath the criteria by Rotterdam.