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    Antibacterial and Washing Resistance Improvement of Cotton Fabric Using Some Metal Oxides
    (Ege Univ, 2021) Koruyucu, Aslıhan; Erdal, Berna; Kurc, Mine Aydin; Gülen, Dumrul
    Cu2O, CuO, ZnO-microparticles with different size and morphology directly influences their antimicrobial potential. In this study, the possible improvement of the antibacterial and washing resistance up to 20 washing cycles performance of 100% cotton fabrics were investigated. At high temperatures, carboxylic acids form ester-type crosslinking with cellulose molecules and provide antibacterial activity. For this purpose, carboxylic acids such as BTCA and CA were used in this study.The purpose of this research was to evaluate 1,2,3,4-butantetracarboxylic acid (BTCA) and citric acid monohydrate (CA) as an crosslinking agent for washing resistance of 100% cotton textile substrates against, Staphylococcus aureus (ATCC 43300), Bacillus subtilis (NRRL NRS -744), Escherichia coli (ATCC 35218) and Klebsiella pneumoniae (ATCC 70063). Cupper oxide and zinc oxide were assimilated in the coating bath for the antibacterial property. BTCA concentration in the solutions influenced the antibacterial and washing properties of the cotton fabrics. The Fourier Transform Infra-Red -Attenuated Total Reflection (FTIR-ATR) spectra showed a new summit that confirmed the ester linkage formation and crosslinking reaction for application.
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    Antimicrobial and Antioxidant Efficacy of the Lipophilic Extract of Cirsium vulgare
    (Mdpi, 2023) Kurc, Mine Aydin; Orak, Hakime Hulya; Gulen, Dumrul; Caliskan, Hilmican; Argon, Merve; Sabudak, Temine
    The aim of this study was to investigate the compounds in the hexane extract of Cirsium vulgare (Savi.) Ten. and to determine the antibacterial, antifungal, and antioxidant activities of different extracts. The Cirsium vulgare (NGBB 7229) plant was collected from Turkey's Trakya region. Crude extracts were obtained using different solvents. The chemical composition of Cirsium vulgare was determined in hexane extract using gas chromatography mass spectrometry. The antioxidant activities of the extracts were evaluated by Trolox equivalent antioxidant activity (TEAC), ferric-reducing antioxidant power (FRAP), cupric-reducing antioxidant capacity (CUPRAC), the beta-carotene bleaching method, and the determination of superoxide anion scavenging activities. The antibacterial activity was tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, and Salmonella typhimurium, whereas the antifungal activity was tested against Candida albicans, Candida glabrata, Candida parapsilosis, Candida krusei, Penicillium chrysogenum, and Aspergillus fumigatus by applying microdilution methods. A total of 41 bioactive compounds were identified using the GC-MS library. Terpenoids were found to be dominant (52.89%), and lup-20(29)-en-3-yl-acetate and lupeol were the most abundant terpenoids. The highest total flavonoid content (25.73 mg catechin/g) and antioxidant capacity were found in the methanolic extract. The highest antibacterial activity was detected against Bacillus subtilis in the ethyl acetate extract, and the highest antifungal activity was found against Candida krusei and Aspergillus fumigatus in the hexane extract. The observed antioxidant characteristics of the C. vulgare extracts could be attributed to the presence of flavonoids. The high antifungal activity of the hexane extract against all fungal strains can be attributed to its constituents, i.e., terpenoids. This study discloses the potential antioxidant and antimicrobial activities, including some bioactive components, of Cirsium vulgare and implies that Cirsium vulgare holds possible applications in the food and pharmaceutical industries as an antioxidant, antibacterial, and antifungal agent.
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    Association between Pityriasis Rosea (PR) and HHV-6/HHV-7 Infection: Importance of Sample Selection and Diagnostic Techniques
    (Mdpi, 2024) Kurc, Mine Aydin; Erfan, Gamze; Kaya, Ayse Demet; Gulen, Dumrul; Oznur, Meltem; Yanik, Mehmet Emin
    Recent studies have focused on the role of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) in PR etiology with varying results. In our study, with the approach that the discrepancy between the results may be related to the different samples and techniques used, we aimed to clarify the etiology by examining tissue and plasma samples using molecular methods and evaluating the results together with serological parameters. Skin biopsies and plasma samples of twenty-five PR patients were tested to detect HHV-6 and HHV-7 DNA using calibrated quantitative real-time polymerase chain reaction (CQ RT-PCR). IgG and IgM antibodies against HHV-6 and HHV-7 were tested by enzyme-linked immunosorbent assay and indirect immunofluorescence. Of the patient group, 64% were positive for HHV-6 IgG without IgM positivity. HHV-6 DNA was present in seven tissue and ten plasma samples. HHV-7 positivity was 100% and 12% for IgG and IgM antibodies, respectively. HHV-7 DNA was detected in four tissue samples and one plasma sample. Patients with HHV-7 DNA-positive plasma and tissue samples had also HHV-7 IgM antibodies. In conclusion, our results seem to support the role of HHV-6/HHV-7 in the etiology of PR. To clarify the etiology of PR and avoid confusion, the collection of different biological materials simultaneously and the usage of CQ RT-PCR as a diagnostic technique are recommended.
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    Do we really need to coat the novel silicone intranasal splints with antibiotics?
    (W B Saunders Co-Elsevier Inc, 2016) Çiftçi, Zafer; Kurc, Mine Aydin; Kaya, Ayşe Demet; Saraçoğlu Varol, Gamze; Deniz, Mahmut; Gültekin, Erdoğan
    Purpose: The novel silicone intranasal splints are suggested to resist biofilm formation due to their surface characteristics. We aimed to ascertain the necessity of coating these splints with antibiotics to prevent splint associated infections, in vitro. Materials and methods: Pieces of Doyle II airway nasal splints made of medical grade silicone were divided into two test groups, treated with either (i) 0.2% nitrofurazone solution or (ii) 0.2% nitrofurazone containing ointment, and a control group, treated with (iii) 0.9% saline. Splint pieces were then incubated with Staphylococcus aureus solutions at 37 degrees C for 48 and 96 h. Following this, the splint pieces were incubated in 20 ml Mueller Hinton agar and appearing colonies were counted. Results: Following 48 and 96 h of incubation, the colonization rates in the saline group were significantly higher than the nitrofurazone ointment group (p < 0.001). The colonization rates in the liquid nitrofurazone group were significantly lower in comparison to the nitrofurazone ointment group (p < 0.001 and p = 0.019 respectively). Conclusions: The method of coating the splints with antibiotic was superior to using uncoated splints in terms of preventing S. aureus colonization. The rather smooth surfaces of the splints were insufficient to block bacterial colonization and coating them with antibiotics seems to be beneficial for the prevention of infections. (C) 2016 Elsevier Inc. All rights reserved.
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    Invasive pulmonary aspergillosis evaluation in hematology patients: Three years results of tertiary hospital
    (Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2024) Kurc, Mine Aydin; Gunaydin, Betul; Akpinar, Seval; Safak, Birol; Kiraz, Nuri
    Invasive pulmonary aspergillosis (IPA) is the most frequent invasive fungal disease occurring in patients with hematological malignancies. Serum galactomannan (GM) antigen monitoring is thought to be helpful in the diagnosis of IPA. The aim of this study was to determine the role of a GM assay in serum samples for the diagnosis of IPA in patients with hematological disease. The data of 366 immunosuppressed patients that were hospitalized and followed up in the hematology clinic from January 2017 to December 2019 were retrospectively analyzed. The clinical and radiological findings of the patients and the GM results, requested twice a week, were evaluated. In this study, the incidence of probable and possible IPA was determined to be 15.3% (56/366). Of the cases detected, 28 (50.0%) were patients diagnosed with Acute Myeloid Leukemia (AML), and 34 (60.7%) patients who had compatible clinical and examination findings were started on antifungal treatment. Additionally, AUC (Area Under the Curve) values were calculated by ROC (Receiver Operating Characteristic) analysis, and it was determined that the diagnostic efficiency was more predictive when the cut-off was 0.5 in the GM test for IPA disease. The detection of GM antigen in serum is a very useful and rapid method for diagnosing IPA disease in immunosuppressed hematology patients. However, GM results should be evaluated together with clinical and radiological findings for early diagnosis, and the treatment approach should be determined accordingly.
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    Skin infections caused by Streptococcus pyogenes after the Eid Al-Adha
    (Lippincott Williams & Wilkins, 2023) Safak, Birol; Albayrak, Hulya; Kurc, Mine Aydin; Gunaydin, Betul
    Introduction:Streptococcus pyogenes is Gram-positive bacteria in chain form. Infections typically begin in the throat and skin, although they present with a many different clinical cases. This study aimed to present a different clinical manifestation related to S. pyogenes. Methods:In this study, swab samples were taken from patients who came to our center with skin lesions after Eid al-Adha. Identification was performed using conventional methods (bacitracin susceptibility test and PYR test) and VITEK 2 (bioMerieux, Marcy l'Etoile, France). Phylogenetic tree was generated using the Tamura Nei model of Neighbor-joining method in MEGA 6.0 program. Results:All of the isolated microorganisms were defined as S. pyogenes. Phylogenetic tree revealed that strains were highly related, but there were genetic differences between the strains. Conclusion:While Orf virus (Parapoxvirus) is the most common cause of skin lesions after Eid al-Adha, S. pyogenes was found to be the causative agent in our study. To our knowledge, cases of S. pyogenes skin infection due to religious practices have been reported for the first time.
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    TREATMENT SUCCESS WITH TIGECYCLINE IN COMBINATION IN A CRITICALY ILL BRUCELLOSIS PATIENT: A CASE REPORT
    (Nobel Ilac, 2023) Yesilyurt, I. D. Murat; Kaya, Ayse Demet; Kurc, Mine Aydin
    Neurobrucellosis is serious complication of Brucella infections and treatment options are quite controversial. Due to high relapse rates and treatment failure observed with monotherapy, a combined therapy is applied. In combination therapy, recently promising results are reported when tigecycline is combined with other antibacterial agents. Besides in-vitro studies, human case reports,-predominantly for severe and life-threatening infections-support treatment success. In this study, we are presenting a case of neurobrucellosis, who recieved a combination therapy including tigecycline, ceftriaxone and rifampicin and totally recovered with no sequela. Our case had the signs and symptoms suspecting of neurobrucellosis, but remained underdiagnosed and cardio/pulmonary arrest had occurred. After resuscitation the patient was hospitalized in the intensive care unit (ICU). Diagnosis of brucellosis was based on clinical features, culture and serological tests of blood and cerebrospinal fluid (CSF) samples, neuroimaging and confirmed by molecular methods. Tigecycline was used by intravenous (IV) route in combination with ceftriaxone and rifampicin, as the patient was mechanicaly ventilated and oral intake was by nasogastric (NG) tube. Risk of vomiting which would prevent doxycycline efficiency led us to apply this combination, to eliminate the risk in this critically ill patient. After observing significant improvement, the treatment was replaced with the oral treatment of rifampicin and doxycycline and terminated in six months. In conclusion, tigecycline seems to be a potential treatment option for brucellosis in combination with other drugs, particularly for specific patient groups, and severe and life threatening conditions related with brucellosis, who have limited alternative treatment options.