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Öğe Acute phase response and oxidative stress status in familial Mediterranean fever (FMF)(Taylor & Francis Ltd, 2012) Güzel, Savaş; Andican, Gülnur; Seven, Arzu; Aslan, Mahmure; Bolayırlı, Murat; Güzel, Eda Çelik; Hamuryudan, VedatWe aimed to determine acute phase response (APR) and oxidative stress in patients with familial Mediterranean fever (FMF) and compare these characteristics with those in healthy controls; 20 patients with FMF and 15 healthy controls were enrolled in the study. The erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), fibrinogen, and leukocyte levels were determined as markers of APR. Thiobarbituric acid reactive substances (TBARS), conjugated diene, and lipid hydroperoxide levels were measured as markers of lipid peroxidation. Carbonyl group and thiol (T-SH) levels were analyzed to determine the oxidative damage to proteins, and 8-hydroxy-2-deoxyguanosine (8-OHdG) was measured to reflect DNA oxidation. The erythrocyte glutathione (GSH) level, and glutathione peroxidase (GSH-Px), CuZn superoxide dismutase (CuZn SOD), and catalase activities were measured as markers of antioxidant status. Conjugated diene (p < 0.001) and carbonyl group (p < 0.05) levels were significantly higher and GSH-Px activity (p < 0.01) was significantly lower in FMF patients compared with controls. FMF patients in the attack period (n = 8) had significantly higher CRP, ESR, fibrinogen, and leukocyte levels (p < 0.001) than patients in the attack-free period (n = 12). The T-SH level (p < 0.05) was significantly higher and CuZn SOD activity was significantly lower (p < 0.05) in FMF patients in the attack period. The findings revealed upregulated APR during the attack period in FMF patients and enhanced oxidative stress in the FMF patients as compared to controls.Öğe Alzheimer hastalığında doublecortin-like kinaz-1 düzeyleri ve oksidan durumu(Cukurova Univ, Fac Medicine, 2017) Güzel, Savaş; Yıldız, Özlem; Ünal, Aysun; Kızıler, Ali Rıza; Gulyasar, Tevfik; Güzel, Eda Çelik; Fidan, ÇiğdemPurpose: Alzheimer disease (AD) is a progressive neurodegenerative disease that affects the neurons in various parts of the central nervous system. Recently discovered protein Doublecort like kinase-1 (DCLK-1) is one of the microtubule-associated protein. Our goal is to investigate the relationship of the role of the DCLK-1 in AD disease and oxidative stress. Material and Methods: The study included Alzheimerdisease- diagnosed 60 patients admitted to the clinic with memory disorders, and 30 healthy subjects. In the serum of patient and control group, DCLK-1, tau protein and zinc levels were measured. To assess the presence of oxidative stress, malondialdehyde (MDA), protein carbonyl group (PCG), protein thiol groups (PTG), glutathione (GSH) and catalase levels were detected. Dementia level was staged with Mini-Mental State Examination (MMSE) and Dementia Clinical Staging Scale (CDR). Results: Serum DCLK-1 and tau levels were determined significantly higher in AD compared to the control group). In the group with AD, levels of MDA, and PCG levels were significantly higher and GSH, catalase levels were determined significantly lower. DCLK-1 and MDA levels were determined significantly higher in the group with severe AD compared to the group with mild AD. In AD group, a positive correlation between DCLK-1 and, CDR and MDA; and negative correlation was found between MMSE and B12 vitamin Conclusions: The presence of a relation with increase in DCLK1 levels in AD and risk factors shows that it can be a new marker in assessing the disease.Öğe Assessment of salusin alpha and salusin beta levels in patients with newly diagnosed dipper and non-dipper hypertension(Taylor & Francis Inc, 2021) Alpsoy, Şeref; Doğan, Burçin; Özkaramanlı Gür, Demet; Akyüz, Aydın; Fidan, Çiğdem; Güzel, Savaş; Özkoyuncu, BernaObjective The pathophysiology of non-dipper hypertension has not been clarified. The relationship between salusins with atherosclerosis and hypertension has gained attention in recent years. The aim of this paper is to investigate whether salusins are associated with circadian blood pressure, left ventricular mass index, and diastolic functions in newly diagnosed hypertensives. Methods The study included 88 newly diagnosed hypertensive individuals. Twenty-four-hour ambulatory blood pressure monitoring and echocardiographic examinations were performed. The patients were assigned to dipper hypertension (n = 41) and non-dipper hypertension (n = 47) groups based on the ambulatory blood pressure monitoring results according to the presence of >= a 10% decrease in nighttime blood pressure values or not. Serum salusin alpha and beta levels were determined by electrochemiluminescence immunological test method. Results Compared to dipper hypertension, non-dipper hypertension group demonstrated lower salusin alpha levels (1818.71 +/- 221.67 vs 1963 +/- 200.75 pg/mL,p= .002), mitral E/A, septal E'/A' and higher salusin beta levels (576.24 +/- 68.15 vs 516.13 +/- 90.7 pg/ml,p= .001) and left ventricular mass index. Multivariate logistic regression analysis revealed salusin-alpha (OR 0.474, 95% CI 0.262 to 0.986,p= .001), salusin-beta (OR 2.550, 95% CI 2.123 to 2.991,p= .018), and left ventricular mass index (OR 2.620, 95% CI 2.124 to 2.860,p= .011) as independent predictors of non-dipper hypertension. As candidate markers to predict non-dipper hypertension, decreased salusin alpha, and increased salusin beta levels may mediate crosstalk between sympathetic and parasympathetic systems and indicate poor cardiovascular prognosis in hypertension.Öğe Association between C-peptide level and microalbuminuria in patients with type 2 diabetes mellitus(Cukurova Univ, Fac Medicine, 2018) Boyuk, Banu; Okuturlar, Yıldız; Uludag, Erdoğan; Atalay, Hande; Güzel, Savaş; Çelebi, AslanPurpose: Latest studies suggest that C-peptide may have a beneficial biological role on diabetic nephropathy. The aim of this study is to analyze whether there is an association between serum C-peptide level and microalbuminuria in type 2 diabetes mellitus (T2DM). Materials and Methods: We enrolled 184 T2DM patents and 46 healthy subjects in this study. Clinical variables and routine biochemical tests along with serum C peptide levels measured after an overnight fasting. Serum C peptide levels between 1.1 and 4.4 accepted as normal. 24-hour-urine samples were investigated and values between 30-300mgwere recorded as microalbuminuria. Pearson correlation analysis were used to determine associations between continuous variables. Results: C peptide levels were not significantly difference in T2DM patients compared to healthy controls. Serum C peptide levels showed positive correlation with insulin and microalbminuria with the Pearson correlation analysis. However, there was no significant association between other variables and C peptide levels. Conclusion: A correlation was found between microalbuminuria and serum C-peptide in this present study. Findings suggest C-peptide is related with renal complications of T2DM patients.Öğe Association between C-peptide level and microalbuminuria in patients with type 2 diabetes mellitus(2018) Böyük, Banu; Okuturlar, Yıldız; Uludağ, Erdoğan; Atalay, Hande; Güzel, Savaş; Çelebi, AslanPurpose: Latest studies suggest that C-peptide may have a beneficial biological role on diabetic nephropathy. The aim of this study is to analyze whether there is an association between serum C-peptide level and microalbuminuria in type 2 diabetes mellitus (T2DM). Materials and Methods: We enrolled 184 T2DM patents and 46 healthy subjects in this study. Clinical variables and routine biochemical tests along with serum C peptide levels measured after an overnight fasting. Serum C peptide levels between 1.1 and 4.4 accepted as normal. 24hour-urine samples were investigated and values between 30-300mgwere recorded as microalbuminuria. Pearson correlation analysis were used to determine associations between continuous variables. Results: C peptide levels were not significantly difference in T2DM patients compared to healthy controls. Serum C peptide levels showed positive correlation with insülin and microalbminuria with the Pearson correlation analysis. However, there was no significant association between other variables and C peptide levels. Conclusion: A correlation was found between microalbuminuria and serum C-peptide in this present study. Findings suggest C-peptide is related with renal complications of T2DM patients.Öğe Association Between Serum Fetuin-A levels, Carotid Artery Stiffness, and Intima-Media Thickness in Patients With Normotensive Obstructive Sleep Apnea Syndrome(Sage Publications Inc, 2014) Akyüz, Aydın; Oran, Mustafa; Alpsoy, Şeref; Mutlu, Levent Cem; Akkoyun, Dursun Çayan; Güzel, Savaş; Alp, RecepIncreased carotid intima-media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association between serum fetuin-A levels and carotid artery stiffness and cIMT in patients with normotensive OSAS (n = 50) and non-OSAS controls (n = 38). Compared with controls, there were lower fetuin-A levels (59.4 +/- 6.5 vs 68.2 +/- 5.8 ng/mL, P = .029), higher mean cIMT (0.73 +/- 0.2 vs 0.63 +/- 0.3 mm, P < .001), and greater stiffness (beta) index (7.45 +/- 0.9 vs 5.2 +/- 0.7, P = .001) in the OSAS group. The cIMT and stiffness (beta) index were inversely correlated with fetuin-A levels (r = -.324, P = .033; r = -.466, P < .001, respectively) and positively correlated with apnea hypopnea index (r = .498, P < .001; r = .422, P = .001, respectively) in the OSAS group. Decreased serum fetuin-A levels were associated with subclinical carotid atherosclerosis in patients with normotensive OSAS.Öğe Association between Vitamin D Level and Microvascular Complications in Patients with Type 2 Diabetes(Kare Publ, 2017) Boyuk, Banu; Atalay, Hande; Değirmencioğlu, Şerife; Altay, Murat; Güzel, Savaş; Çelebi, Asian; Ayar, YavuzObjectives: The aim of this study was to further investigate the prevalence of Vitamin D deficiency in diabetes mellitus (DM) patients, as well as the association between hypovitaminosis D and the microvascular complications of type 2 (T2) DM. Methods: This was a cross-sectional, case-control study of 206 T2DM patients and 34 healthy control subjects. Participants were evaluated for the presence of diabetic retinopathy, nephropathy, and neuropathy. Results: The level of serum 25-hydroxyvitamin D (25(OH) D) was significantly lower in the T2DM patients (11.16 +/- 3.99 ng/mL vs. 15.58 +/- 3.16 ng/mL; p<0.05). Furthermore, 2.7% of the patients were found to have retinopathy (n=53), 3.6% had neuropathy (n=65), and 29.1% of the patients had microalbuminuria (n=60). Although serum 25(OH) D levels were significantly lower in the presence of retinopathy and neuropathy (p<0.05 for both), no significant association between Vitamin D level and microalbuminuria was found. Conclusion: An inverse relationship between the circulating 25(OH) D level and the prevalence of retinopathy and neuropathy in T2DM patients was determined. However, there was no significant association between microalbuminuria and the 25(OH) D level.Öğe Association of lower serum irisin levels with diabetes mellitus: Irrespective of coronary collateral circulation, and syntax score(Kare Publ, 2021) Akyüz, Aydın; Mert, Beysim; Özkaramanlı Gür, Demet; Efe, Muhammet Mucip; Aykaç, Hüseyin; Alpsoy, Şeref; Güzel, SavaşOBJECTIVE: Irisin is a myokine thought to be involved in the pathophysiological process of atherosclerosis with its' cardiovascular protective effects. Patients with diabetes mellitus (DM) have lower levels of irisin. Therefore, we investigated whether there is a connection between irisin, DM, coronary collateral circulation (CCC), and SYNTAX scores representing coronary artery disease (CAD) severity. METHODS: This study evaluated 86 patients who have at least one epicardial coronary artery with chronic total occlusion. We included Rentrop 0-1 into the poor CCC group (n=45) and Rentrop 2-3 into the good CCC group (n=41) and measured serum irisin levels. RESULTS: Irisin levels did not differ (17585 [882-37741] pg/ml and (17504 [813-47683] pg/ml, p=0.772) between the two groups. Irisin levels were lower in patients with diabetes (n=41; 14485 [813-29398] pg/ml) than those without diabetes (n=45; 19724 [865-47683] pg/ml (p=0.002). Irisin was not correlated with SYNTAX scores. In multivariate analysis, DM (OR=0.463; CI: 0.184-0.783; p=0.012) was a negative predictor of good CCC development CONCLUSION: Although its level is decreased in patients with diabetes, serum irisin levels have no role in the pathophysiology of collateral development and CAD severity.Öğe Association of Pb, Cd, and Se Concentrations and Oxidative Damage-Related Markers in Different Grades of Prostate Carcinoma(Humana Press Inc, 2012) Güzel, Savaş; Kiziler, Lebriz; Aydemir, Birsen; Alıcı, Bülent; Ataus, Süleyman; Aksu, Abdullah; Durak, HaydarProstate cancer is known to be affected by the heavy metal levels and oxidative damage of the body, yet there are very few studies which look into the way it occurs. The aim of this study was to determine whether blood and tissue lead (Pb), cadmium (Cd), and selenium (Se) levels are associated with oxidative damage in the context of prostate cancer progression and development. Seventy-nine patients comprising 25 patients with benign prostatic hypertrophy (BPH), 23 patients with malignant prostatic carcinoma (malign Ca), 16 patients with low-grade prostatic intraepithelial neoplasia (LGPIN), and 15 patients with high-grade prostatic intraepithelial neoplasia (HGPIN) diagnosed on the basis of their clinical profile, transrectal ultrasonography, and histopathology were included in this study. Cd and Pb levels in whole blood were found to be increased in patients with HGPIN compared with the BPH group; also, the levels of Cd in whole blood and tissue were found to be increasing in patients with malign Ca, unlike BPH patients. Moreover, the levels of malondialdehyde (MDA) in plasma and tissue were significantly increased in malign Ca, LGPIN, and HGPIN than those in BPH. However, the levels of tissue Pb were found to be decreasing in BPH, unlike the malign Ca and HGPIN patients, and the levels of tissue protein carbonyls in malign Ca were significantly lower than those in HGPIN. The levels of tissue reduced glutathione (GSH) in malign Ca were significantly lower than those in BPH. Additionally, the levels of Se in serum and tissue in LGPIN were significantly lower than those in BPH. The serum Se levels in HGPIN were also significantly lower than those in BPH and malign Ca groups. Furthermore, the concentrations of serum Se in LGPIN were significantly lower than those in malign Ca. From the Pearson correlation analysis, there were significant positive correlations between tissue Cd and MDA levels in malign Ca, LGPIN, and HGPIN and between the tissue Pb and tissue MDA and protein carbonyl levels in malign Ca. Blood Pb and tissue Pb were also significantly positively correlated with plasma MDA and protein carbonyl levels in malign Ca. In addition, blood Pb was significantly positively correlated with tissue MDA and protein carbonyl levels in malign Ca, and a significant positive correlation was also found between blood Cd and plasma protein carbonyls and tissue MDA in LGPIN. We observed that altered prooxidant-antioxidant balance and heavy metal levels may lead to an increase in oxidative damage and may consequently play an important role in prostate carcinogenesis. These findings indicate that changes in the levels of Pb, Cd, Se, MDA, protein carbonyls, and GSH in the blood and/or tissue are related to the prostatic carcinoma development and progression, although triggering one of the mentioned changes is unknown; therefore, further study is required to determine the exact steps of the process and clarify the roles of different substances in order to obtain a more detailed explanation of the phenomenon.Öğe Associations of Nutritional Status, Oxidative Parameters, and Quality of Life of Breast Cancer Patients Before, During, and After Chemotherapy(2022) Kaya, Aysel Şahin; Yetişyiğit, Tarkan; Yılmaz, Ahsen; Güzel, Savaş; Mutlu, Aslı AkyolAim: Monitoring the nutritional status of cancer patients is crucial. We aimed to assess the associations between nutritional status, oxidative parameters and quality of life before, during, and after chemotherapy (CT) in breast cancer patients. Material and Method: Clinical, anthropometric, demographic, quality of life, laboratory (i.e., blood oxidative marker level) and dietary intake data of breast cancer patients who planned to have two cycles of CT were recorded. All collected data were compared between pre-CT, mid-CT, and post-CT time points. Results: Fifty women who were diagnosed with breast cancer and would start CT treatment were included in the study. Post-CT body weight and BMI was significantly lower than the pre-CT values (p?0.001). They both turned back to pre-CT levels at the end of CT with a decrease in total daily caloric and macronutrient intake. Consumption of specific food groups such as milk or yogurt, cheese, eggs, and sugar significantly decreased compared to their pre-CT consumption levels (p?0.001, p?0.001, p=0.017, and p=0,01). Blood oxidative stress marker analysis revealed a significant reduction in GPx levels with CT (p=0.007). Analysis of the quality-of-life scores revealed that post-CT scores were significantly higher than the pre-CT scores while the life quality was lowest in the mid-CT period. Conclusion: Breast cancer patients have a lower dietary intake during CT, which is associated with a lower intake of specific food groups. Adequate caloric intake and antioxidant intake should be recommended to these patients during CT via dietary counseling to maintain healthy anthropometric measures and oxidative hemostasis.Öğe Atherosclerosis, some serum inflammatory markers in psoriasis(Edizioni Minerva Medica, 2014) Alpsoy, Şeref; Akyuz, A.; Erfan, Gamze; Akkoyun, Dursun Çayan; Topçu, Birol; Güzel, Savaş; Kulaç, MustafaAim. Psoriasis is an autoimmune inflammatory disease which is associated with increased inflammatory markers and atherosclerosis. We wanted to investigate whether there is a relationship between some inflammatory markers and subclinical atherosclerosis markers. Methods. We studied 60 psoriasis patients and 50 healthy controls. Demographic, biochemical parameters, C3, C4, d-dimer, CRP, fibrinogen and YKL-40 (human cartilage glyco-protein-39) levels were measured. After measuring carotid intima-media thickness (cIMT) and aortic elasticity parameters such as aortic strain, (beta) stiffness index and compliance, statistical comparisons were done. Results. Patients with psoriasis had significantly higher diastolic blood pressure, CRP, fibrinogen, C3, uric acid levels, beta-stiffness index, and cIMT values than the control group. cIMT was correlated with CRP, YKL-40 and psoriasis area and severity index (PASI) score (r=0.219, P=0.038; r=0.225, P=0.033 and r=0.275, P=0.034). Aortic strain (%), aortic compliance and aortic stiffness index were correlated with C3 (r=-0.349, r=-0.526 and r=0.235) and fibrinogen (r=-0.354, r=-0.275 and r=0.289), all P values <0.05, but not with PASI score. The presence of psoriasis was related to aortic strain (beta +/- SE: -2.055 +/- 0.861, P=0.019) and beta-stiffness index (beta +/- SE: 2.934 +/- 1.143, P=0.012). Conclusion. Serum C3, CRP, fibrinogen and YKL-40 levels are elevated as well as increased cIMT and impaired aortic elasticity in psoriasis. CRP, YKL-40 and PASI score are correlated with cIMT. Increased serum C3 and fibrinogen levels correlate negatively with aortic strain and aortic compliance, and correlate positively with the beta-stiffness index.Öğe Author's Reply [2020](Turkish Society of Cardiology, 2020) Akyüz, Aydın; Aydın, Fatma; Alpsoy, Şeref; Özkaramanlı Gür, Demet; Güzel, Savaş[No abstract available]Öğe BRONŞİOLİTLİ ÇOCUKLARDA HASTALIK AKTİVİTESİNİN DEĞERLENDİRİLMESİNDE NÖTROFİL/LENFOSİT ORANI YENİ BİR BİYOBELİRTEÇ OLABİLİR Mİ?(Tekirdağ Namık Kemal Üniversitesi, 2019) Çelik Güzel, Eda; Fidan, Çiğdem; Güzel, Savaş; Paketçi, Cem; Çelikkol, AliyeAmaç: Akut bronşiolit, inflamatuar bir hastalıktır. Nötrofil/lenfosit oranı (NLO) çeşitli inflamatuar hastalıklarda arttığı bilinen inflamatuar belirteçlerdir. Bu çalışmada amacımız bronşiolitli çocuk hastalarda NLO değerlerini incelemek ve hastalık şiddetiyle ilişkisini değerlendirmektir. Materyal ve Metot: Çalışma akut bronşiolit tanısı alan 3 ay ile 5 yaş arasında 77 hasta ve 34 sağlıklı çocuktan oluşturuldu. Hasta ve kontrol grubunda C-reaktif protein (CRP), beyaz küre sayısı (BKS), ortalama trombosit hacmi (OTH), nötrofil ve lenfosit değerleri ile birlikte NLO değerleri incelendi. Bulgular: Akut bronşiolit grubunda CRP, BKS, NLO ve nötrofil sayısı kontrol grubuna göre anlamlı olarak yüksek saptandı (sırasıyla p<0.01, p<0.001, p<0.001, p<0.001). OTH düzeyleri hasta grubunda anlamlı olarak düşük bulundu (p<0.05). Hastalık şiddetine göre hasta grubu hafif, orta ve ağır olmak üzere üç gruba ayrıldı. Orta bronşiolitli hastalarda (n=21); nötrofil ve NLO değerleri hafif bronşiolitli gruba (n=25) göre anlamlı olarak yüksek saptandı (Her ikisi de p<0.05). Korelasyon analizinde; NLO ile OTH, BKS, CRP arasında pozitif korelasyon saptandı (sırasıyla r=0.262–p<0.05; r=0.454–p<0.001; r=0.706–p<0.001). Akut bronşiolitli hastaların hastaneye kabulde incelenen parametrelerden yalnızca CRP için Receiver-operating characteristic (ROC) analizinde eğri altında kalan alan (EAA) sonuçları tanısal olarak yeterli bulunurken (0.812), BKS ve NLO için yeterlilik saptanamadı (sırasıyla 0.692, 0.583). Sonuç: Çalışmamızda, hastaneye başvuruda saptanan artmış CRP düzeylerinin; bronşiolit gelişecek hastaları predikte etmede ve artmış NLO oranının hastalık şiddetinin belirlenmesinde iyi bir belirteç olabileceğini göstermektedir.Öğe C-reactive protein (CRP)/mean platelet volume (MPV) ratio as a new biomarker for community-acquired pneumonia in children(Cukurova Univ, Fac Medicine, 2017) Güzel, Eda Çelik; Fidan, Çiğdem; Güzel, Savaş; Paketci, CemPurpose: Our aim is to evaluate the relationship between C-reactive protein (CRP)/mean platelet volume (MPV) ratio and white blood cell (WBC)/mean platelet volume (MPV) ratio and diagnosis and disease severity in children with community-acquired pneumonia (CAP). Material and Methods: 60 patients with CAP including 33 mild-moderate (Group 1) and 27 severe pneumonia (Group 2) and 30 healthy children were examined for routine blood test. WBC, MPV, neuotrophile/lymhocyte ratio (NLR), CRP, WBC/MPV, CRP/MPV values were recorded on each patient and healthy groups. Result: CRP/MPV, WBC/MPV, NLR and plateletcrit values were significantly higher in patients group than controls, while MPV value is not correlated between patient and control groups. WBC, NLR, WBC/MPV, CRP/MPV and CRP values were higher in the Group 2 compared to Group 1. CRP/MPV and WBC/MPV were positively correlated with duration of symptoms in the CAP. The area under ROC curve of CRP, WBC and WBC/MPV in diagnosing CAP was significant (0.801, 0.761 and 0.731). Also the area under ROC curve of Group 2 in CRP/MPV and CRP in diagnosing CAP was significant (0.733, 0.708). Conclusion: CRP/MPV and WBC/MPV ratio may be used a marker in the evaluation of CAP diagnosis and CRP/MPV ratio can be good marker prediction of disease activity.Öğe Calprotectin levels in patients with rheumatoid arthritis to assess and association with exercise treatment(Springer London Ltd, 2016) Acar, Ayşe; Güzel, Savaş; Sarıfakıo?lu, Ayşe Banu; Çelik Güzel, Eda; Yıldırım Güzelant, Aliye; Karadağ, Ceyda; Kızıler, LebrizRheumatoid arthritis (RA) is a chronic, inflammatory, and autoimmune disease that can cause permanent joint damage. In our study, we aim to analyze the change in calprotectin levels following the low-density exercise levels applied to the patients with RA. Twenty-eight patients with RA and 30 healthy controls were included in this study. To evaluate the activity of disease in RA, scores of disease activity that has increased (DAS-28) are figured. Calprotectin, nitric oxide (NO), white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor (RF) levels are tested as the laboratory evaluation. Calprotectin, NO, CRP, ESR, WBC, and RF levels were significantly higher in the patient group compared to the control group (p < 0.01, p < 0.001, p < 0.01, p < 0.01, p < 0.01, and p < 0.05, respectively). In correlation analysis applied to the patient group with RA, there has been determined a positive relation with calprotectin, and DAS-28, CRP, NO, RF, and WBC (p < 0.001, p < 0.05, p < 0.001, p < 0.05, and p < 0.05, respectively). In result of the low-density exercise treatment applied to patients with RA for 8 weeks, there has been determined a significant decrease in calprotectin, DAS-28, NO, CRP, ESR, and RF levels (p < 0.05, p < 0.001, p < 0.01, p < 0.05, p < 0.05, and p < 0.05, respectively). As a result, a significant relation is found between RA disease activity and calprotectin levels and other inflammatory parameters. At the same time, it shows that calprotectin which is a significant indicator of local inflammation can be used as a good identifier in following up exercise treatment.Öğe Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?(Dove Medical Press Ltd, 2014) Güzel, Eda Çelik; Bakkal, Esra; Güzel, Savaş; Eroğlu, Hasan Emre; Acar, Ayşe; Küçükyalçın, Volkan; Topçu, BirolObjective: Depression is a common condition in obese women that can result in severe impairment of their physical and social functioning. A deficiency of brain-derived neurotrophic factor (BDNF) is involved in the mechanism of depression. The aim of this study is to investigate whether BDNF levels differ between obese female patients and healthy controls and whether BDNF levels alter with affective states in depressive obese women. Methods: The study group included 40 obese, 40 preobese, and 40 normal weight women. BDNF levels were measured with an enzyme-linked immunosorbent assay in patient and control groups. For identifying the depression and anxiety status, Beck Depression/Anxiety Inventories were used; and for the evaluation of cognitive functions, the mini-mental state examination was used. Results: BDNF levels were significantly lower in obese patients compared to the control group (P. 0.01). BDNF levels were significantly lower in obese patients with depression compared to the obese patients without depression (P<0.05). The Beck Depression Inventory showed a negative correlation with BDNF (r=-0.044; P<0.01) and a positive correlation with the Beck Anxiety Inventory (r= 0.643; P<0.001), vitamin B12 levels (r= 0.023; P<0.001), and insulin levels (r= 0.257; P<0.05) in obese patients. When receiver operating characteristic curve analysis was used to analyze the suitability of BDNF to identify depression in obese women, the area under the curve for BDNF, 0.756, was found to be significant (P=0.025). BDNF levels lower than 70.2 pg/mL were associated with a higher prevalence of depressive symptoms. Conclusion: The results of our study suggest that the decrease in BDNF levels can be used as a marker for depression diagnosis in obese patients.Öğe Cardiovascular disease risk prediction in scleroderma(Assoc Medica Brasileira, 2023) Çelikkol, Aliye; Mercan, Rıdvan; Güzel, Savaş; Yılmaz, AhsenOBJECTIVE: Cardiovascular disease risk prediction in scleroderma is important. In this study of scleroderma patients, the aim was to investigate the relationship between cardiac myosin-binding protein-C, sensitive troponin T, and trimethylamine N-oxide and cardiovascular disease risk with the Systematic COronary Risk Evaluation 2 model of the European Society of Cardiology.METHODS: Systematic COronary Risk Evaluation 2 risk groups of 38 healthy controls and 52 women with scleroderma were evaluated. Cardiac myosin-binding protein-C, sensitive troponin T, and trimethylamine N-oxide levels were analyzed with commercial ELISA kits.RESULTS: In scleroderma patients, cardiac myosin-binding protein-C and trimethylamine N-oxide levels were higher than healthy controls but sensitive troponin T was not (p<0.001, p<0.001, and p=0.274, respectively). Out of 52 patients, 36 (69.2%) were at low risk, and the other 16 (30.8%) patients were at high-moderate risk with the Systematic COronary Risk Evaluation 2 model. At the optimal cutoff values, trimethylamine N-oxide could discriminate high-moderate risk with sensitivity 76%, specificity 86% and cardiac myosin-binding protein-C with sensitivity 75%, specificity 83%. Patients with high trimethylamine N-oxide levels (>= 10.28 ng/mL) could predict high -moderate-Systematic COronary Risk Evaluation 2 risk 15 times higher than those with low trimethylamine N-oxide (<10.28 ng/mL) levels (odds ratio [OR]: 15.00, 95%CI 3.585-62.765, p<0.001). Similarly, high cardiac myosin-binding protein-C (>= 8.29 ng/mL) levels could predict significantly higher Systematic COronary Risk Evaluation 2 risk than low cardiac myosin-binding protein-C (<8.29 ng/mL) levels (OR: 11.00, 95%CI 2.786-43.430).CONCLUSION: Noninvasive cardiovascular disease risk prediction indicators in scleroderma, cardiac myosin-binding protein-C, and trimethylamine N-oxide could be recommended to distinguish between high-moderate risk and low risk with the Systematic COronary Risk Evaluation 2 model.Öğe Causes of Elevated Levels of Serum CA 19.9 in Patients without Prior Diagnosis of Malignant Disease(2019) Şeber, Erdoğan Selçuk; Güzel, Savaş; Yılmaz, Ahsen; Kara, Sonat Pınar; Yetişyiğit, TarkanObjective: Serum CA 19.9 is commonly used as a tumor marker for diagnosis and followup of gastrointestinal malignancies. However, elevated levels can be found in various clinicalconditions.Methods: A total of 285 patients whose serum CA 19.9 level was ordered from variousoutpatient clinics other than oncology in a tertiary hospital setting and who had elevated CA19.9 (>34 U/mL) levels were included in the study group. Statistical analysis of marker levelsin relation to diagnosis of patients was performed.Results: Overall, 226 patients with benign disorders and 59 patients with malignant diseasehad elevated CA 19-9 levels. One hundred ten (39%) patients with increased CA 19-9 levelsdid not have any significant clinical condition associated with high CA 19-9 values. MedianCA 19-9 levels were significantly higher in patients with malignancies than in patients withbenign disorders (67.3 vs. 47.9; p<0.001). Receiver operating characteristic curve analysisidentified a cut-off value of 66.3 U/mL for discrimination of malignant from benign gastrointestinal diseases (sensitivity 58.3% and specificity 82.7%; p<0.001).Conclusion: Serum CA 19-9 levels are significantly higher in patients with malignant diseases. However, there are diverse etiologies associated with elevated serum levels. Duringchronic inflammatory states, elevated serum CA 19-9 levels can be a frequent finding.Öğe Chemerin and calprotectin levels correlate with disease activity and inflammation markers in psoriasis vulgaris(Elsevier Taiwan, 2015) Güzel, Savaş; Erfan, Gamze; Kulaç, Mustafa; Güzel, Eda Çelik; Küçükyalçın, Volkan; Kaya, Şule; Kızıler, Ali RızaBackground: Psoriasis is a chronic inflammatory dermatosis that affects about 2-3% of the general population. We aimed to investigate the relationship between serum chemerin and calprotectin levels and the inflammatory markers that can lead to oxidative damage. Methods: Fifty patients with psoriasis and 30 healthy controls were included in the study. Levels of chemerin and calprotectin were measured in addition to levels of C-reactive protein, the erythrocyte sedimentation rate, and the white blood cell count to evaluate inflammation. Results: According to our findings, chemerin and calprotectin levels in the patient group were significantly higher than in the control group (p <0.01 and p < 0.001. respectively). Patients with psoriasis were divided into three groups based on the Psoriasis Area and Severity Index: mild, moderate, and severe. The chemerin levels in the severe and moderate groups were significantly higher than in the mild group (p < 0.01 and p < 0.05, respectively). The calprotectin levels in the severe psoriasis group were also significantly higher than in the mild group (p < 0.05). Similarly, the erythrocyte sedimentation rate and levels of fibrinogen and C-reactive protein were significantly higher in patients with psoriasis than in the control group (p < 0.05, p <0.01. and p < 0.001, respectively). Stepwise regression analysis was used to assess the individual contributing factors. Among these contributing factors, the chemerin levels were observed to be positively correlated with both the Psoriasis Area and Severity Index (R-2 = 0.111) and the calprotectin level (R-2 = 0.445). Calprotectin was observed to be positively correlated with both the C-reactive protein (R-2 = 0.119) and chemerin levels (R-2 = 0.315). Conclusion: The chemerin and calprotectin levels in patients with psoriasis showed that there is an inflammatory process in psoriasis and that these markers are useful indicators of the severity of psoriasis. (C) Copyright 2014, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC. All rights reserved.Öğe Childhood asthma and vitamin D deficiency in Turkey: is there cause and effect relationship between them?(Bmc, 2013) Uysalol, Metin; Mutlu, Levent Cem; Saraçoğlu Varol, Gamze; Karasu, Erkut; Güzel, Savaş; Kayaoğlu, Semra; Uzel, NedretBackground: Epidemiological studies show that vitamin D deficiency and insufficiency are common worldwide and associated with many diseases including asthma. Our aim was to evaluate vitamin D insufficiency and its clinical consequences. Methods: This cross-sectional study was carried out on 170 children consisted of 85 who were asthmatic and 85 who were not, aged 2 to 14 years in Tekirdag, Turkey, from September 2009 to May 2010. Children's basal serum D vitamin levels were determined, and their eating habits, vitamin D intake, exposure to sunlight and use of health services during the previous year were investigated. The severity of asthma and levels of asthma control were assessed according to the Global Initiative for Asthma guidelines. Results: The difference between mean vitamin D levels in the asthmatic group (mean +/ SD) 16.6 +/ 8.5 ng/mL and the healthy control group (mean +/- SD) 28.2 +/- 19.5 ng/mL was found to be statistically significant (p < 0.001). Children in the asthma group had less exposure to sunlight and ate a diet less rich in vitamin D (p < 0.001). A significant difference was observed between the groups regarding the frequency of respiratory tract infections leading to emergency unit admissions and number of hospitalizations (p < 0.001). It was also shown that a decrease in vitamin D level increased the severity of asthma (p < 0.001) and decreased the frequency of controlled asthma (p = 0.010). Conclusion: This study has demonstrated the correlation between plasma 25 (OH) D levels and childhood asthma. Evidently, this relationship being influenced by multiple factors other than vitamin D, further studies should be conducted to explore the interrelation between all such factors.
