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A Different Look at Premarital Hemoglobinopathy Screening in Primary Care
(2021) Güzel, Eda Çelik; Çelikkol, Aliye; Mekik, Haluk
Objective: Despite the high prevalence of hemoglobinopathies (HBP), the most common single-gene disorders in Turkey, data in some regions are lacking. We aimed to evaluate the effectiveness of the hemoglobinopathy premarital screening program (PMS) and to investigate the contribution of efficient use of complete blood count (CBC) parameters on cost-effectivity. Methods: HMP diagnosed 49171 subjects in 4 years and CBC of subjects with HMP in a year were evaluated retrospectively. Results: The total incidence rate of HBP was 3.41%, ?-thalassemia trait (?-TT) was 1.98%, HMP incidence in the PMS group was 2.43%, ?-TT was 1.08%. Moreover, HbF, HbD, HbC, HbS, HbE and HbJ were detected with the incidences of 0.49%, 0.14%, 0.05%, 0.04%, 0.007% and 0.009%, respectively. RDW/MCH ratio compared to other indices was the most successful for both sexes in diagnostic efficiency of HBP (AUC: male:0.922 - female:0.961) and ?-TT (AUC: male;0.928 - female:0.961). Conclusions: PMS was found to be an effective application program in HMP screening. RDW/MCH ratio was the most useful and easy parameter in detecting HBP and ?-TT in PMS and in terms of reducing unnecessary test requests and cost-effectiveness in public health screenings.
A Novel Combined Index of D-Dimer, Fibrinogen, Albumin, and Platelet (FDAPR) as Mortality Predictor of COVID-19
(Wolters Kluwer Medknow Publications, 2022) Çelikkol, Aliye; Doğan, Mustafa; Güzel, Eda Çelik; Erdal, Berna; Yılmaz, A.
Background: In coronavirus disease 2019 (COVID-19) caused by SARSCoV2 viruses, coagulation abnormalities are strongly correlated between disease severity and mortality risk. Aims: The aim was to search for new indices to determine mortality risk. Fibrinogen times D-dimer to albumin times platelet ratio calculated with the formula (FDAPR index: ((Fibrinogen x D-dimer)/(Albumin x Platelet)) investigated as a mortality marker in COVID-19 patients. The hospitalization data of 1124 patients were analyzed from the electronic archive system. Hemogram, coagulation, and inflammatory markers were investigated in the study group. Materials and Methods: All statistical analyses like the student t-test, Mann-Whitney U, Kaplan-Meier, and Cox hazard ratio, were performed with the SPSS 22.0 program. Results: Prothrombin time was prolonged significantly in patients (P < 0.05) compared to healthy subjects (n = 30). D-dimer and fibrinogen were high, and albumin and platelet counts were low in COVID-19 patients (all, P < 0.001). When the data of 224 non-survivors and 900 survived patients were compared, D-dimer and fibrinogen were higher, and albumin and platelet lower (all, P < 0.001) compared to mild and severe patients. At the cut-off value of 0.49, the FDAPR index was performed with 89.1% sensitivity and 88.6% specificity. FDAPR index had the highest mortality predictive power (P < 0.01; HR = 5.366; 95% CI; 1.729-16.654). Conclusions: This study revealed that the FDAPR index could be used as a mortality marker of COVID-19 disease.
A novel combined index of D-dimer, fibrinogen, albumin, and platelet (FDAPR) as mortality predictor of COVID-19
(Wolters Kluwer Medknow Publications, 2022) Çelikkol, Aliye; Doğan, Mustafa; Güzel, Eda Çelik; Erdal, Berna; Yılmaz, A.
Background: In coronavirus disease 2019 (COVID-19) caused by SARSCoV2 viruses, coagulation abnormalities are strongly correlated between disease severity and mortality risk. Aims: The aim was to search for new indices to determine mortality risk. Fibrinogen times D-dimer to albumin times platelet ratio calculated with the formula (FDAPR index: ((Fibrinogen × D-dimer)/(Albumin × Platelet)) investigated as a mortality marker in COVID-19 patients. The hospitalization data of 1124 patients were analyzed from the electronic archive system. Hemogram, coagulation, and inflammatory markers were investigated in the study group. Materials and Methods: All statistical analyses like the student t-test, Mann-Whitney U, Kaplan-Meier, and Cox hazard ratio, were performed with the SPSS 22.0 program. Results: Prothrombin time was prolonged significantly in patients (P < 0.05) compared to healthy subjects (n = 30). D-dimer and fibrinogen were high, and albumin and platelet counts were low in COVID-19 patients (all, P < 0.001). When the data of 224 non-survivors and 900 survived patients were compared, D-dimer and fibrinogen were higher, and albumin and platelet lower (all, P < 0.001) compared to mild and severe patients. At the cut-off value of 0.49, the FDAPR index was performed with 89.1% sensitivity and 88.6% specificity. FDAPR index had the highest mortality predictive power (P < 0.01; HR = 5.366; 95% CI; 1.729-16.654). Conclusions: This study revealed that the FDAPR index could be used as a mortality marker of COVID-19 disease. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
Acute phase response and oxidative stress status in familial Mediterranean fever (FMF)
(Taylor & Francis Ltd, 2012) Güzel, Savaş; Andican, Gülnur; Seven, Arzu; Aslan, Mahmure; Bolayırlı, Murat; Güzel, Eda Çelik; Hamuryudan, Vedat
We aimed to determine acute phase response (APR) and oxidative stress in patients with familial Mediterranean fever (FMF) and compare these characteristics with those in healthy controls; 20 patients with FMF and 15 healthy controls were enrolled in the study. The erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), fibrinogen, and leukocyte levels were determined as markers of APR. Thiobarbituric acid reactive substances (TBARS), conjugated diene, and lipid hydroperoxide levels were measured as markers of lipid peroxidation. Carbonyl group and thiol (T-SH) levels were analyzed to determine the oxidative damage to proteins, and 8-hydroxy-2-deoxyguanosine (8-OHdG) was measured to reflect DNA oxidation. The erythrocyte glutathione (GSH) level, and glutathione peroxidase (GSH-Px), CuZn superoxide dismutase (CuZn SOD), and catalase activities were measured as markers of antioxidant status. Conjugated diene (p < 0.001) and carbonyl group (p < 0.05) levels were significantly higher and GSH-Px activity (p < 0.01) was significantly lower in FMF patients compared with controls. FMF patients in the attack period (n = 8) had significantly higher CRP, ESR, fibrinogen, and leukocyte levels (p < 0.001) than patients in the attack-free period (n = 12). The T-SH level (p < 0.05) was significantly higher and CuZn SOD activity was significantly lower (p < 0.05) in FMF patients in the attack period. The findings revealed upregulated APR during the attack period in FMF patients and enhanced oxidative stress in the FMF patients as compared to controls.
Alzheimer hastalığında doublecortin-like kinaz-1 düzeyleri ve oksidan durumu
(Cukurova Univ, Fac Medicine, 2017) Güzel, Savaş; Yıldız, Özlem; Ünal, Aysun; Kızıler, Ali Rıza; Gulyasar, Tevfik; Güzel, Eda Çelik; Fidan, Çiğdem
Purpose: Alzheimer disease (AD) is a progressive neurodegenerative disease that affects the neurons in various parts of the central nervous system. Recently discovered protein Doublecort like kinase-1 (DCLK-1) is one of the microtubule-associated protein. Our goal is to investigate the relationship of the role of the DCLK-1 in AD disease and oxidative stress. Material and Methods: The study included Alzheimerdisease- diagnosed 60 patients admitted to the clinic with memory disorders, and 30 healthy subjects. In the serum of patient and control group, DCLK-1, tau protein and zinc levels were measured. To assess the presence of oxidative stress, malondialdehyde (MDA), protein carbonyl group (PCG), protein thiol groups (PTG), glutathione (GSH) and catalase levels were detected. Dementia level was staged with Mini-Mental State Examination (MMSE) and Dementia Clinical Staging Scale (CDR). Results: Serum DCLK-1 and tau levels were determined significantly higher in AD compared to the control group). In the group with AD, levels of MDA, and PCG levels were significantly higher and GSH, catalase levels were determined significantly lower. DCLK-1 and MDA levels were determined significantly higher in the group with severe AD compared to the group with mild AD. In AD group, a positive correlation between DCLK-1 and, CDR and MDA; and negative correlation was found between MMSE and B12 vitamin Conclusions: The presence of a relation with increase in DCLK1 levels in AD and risk factors shows that it can be a new marker in assessing the disease.
Birinci Basamakta Lyme Artriti; Olgu Sunumu
(Duzce Univ, 2019) Güzel, Eda Çelik; Köse, Ayca; Barut, Kenan; Toprak, Dilek; Çelikkol, Alive
Primary health care is the closest point to the patient. The person who is ill or suspicious of his / her health goes to the family physician, the family health center or the closest health institution. The correct diagnosis and treatment at Primary health care center is of great importance in terms of the cost effectiveness and public health improvement. Lyme arthritis is one of the diseases caused by Borrelio Burgdorferi, spirochete passing through the bite of the hard ticks of Ixodes. Infections may involve the skin, central nervous system, heart, eye and other organs, while in most cases joints are the main site of involvement. A very small percentage of children presenting with arthritis complaints have Lyme arthritis. In Europe, the most common form of arthritis following bacterial infection in children and adolescents is Lyme arthritis. Frequently, joint swelling is accompanied by pain. In this case report, we present a patient with Lyme arthritis who complained of pain, swelling, and inability to walk.
C-reactive protein (CRP)/mean platelet volume (MPV) ratio as a new biomarker for community-acquired pneumonia in children
(Cukurova Univ, Fac Medicine, 2017) Güzel, Eda Çelik; Fidan, Çiğdem; Güzel, Savaş; Paketci, Cem
Purpose: Our aim is to evaluate the relationship between C-reactive protein (CRP)/mean platelet volume (MPV) ratio and white blood cell (WBC)/mean platelet volume (MPV) ratio and diagnosis and disease severity in children with community-acquired pneumonia (CAP). Material and Methods: 60 patients with CAP including 33 mild-moderate (Group 1) and 27 severe pneumonia (Group 2) and 30 healthy children were examined for routine blood test. WBC, MPV, neuotrophile/lymhocyte ratio (NLR), CRP, WBC/MPV, CRP/MPV values were recorded on each patient and healthy groups. Result: CRP/MPV, WBC/MPV, NLR and plateletcrit values were significantly higher in patients group than controls, while MPV value is not correlated between patient and control groups. WBC, NLR, WBC/MPV, CRP/MPV and CRP values were higher in the Group 2 compared to Group 1. CRP/MPV and WBC/MPV were positively correlated with duration of symptoms in the CAP. The area under ROC curve of CRP, WBC and WBC/MPV in diagnosing CAP was significant (0.801, 0.761 and 0.731). Also the area under ROC curve of Group 2 in CRP/MPV and CRP in diagnosing CAP was significant (0.733, 0.708). Conclusion: CRP/MPV and WBC/MPV ratio may be used a marker in the evaluation of CAP diagnosis and CRP/MPV ratio can be good marker prediction of disease activity.
Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?
(Dove Medical Press Ltd, 2014) Güzel, Eda Çelik; Bakkal, Esra; Güzel, Savaş; Eroğlu, Hasan Emre; Acar, Ayşe; Küçükyalçın, Volkan; Topçu, Birol
Objective: Depression is a common condition in obese women that can result in severe impairment of their physical and social functioning. A deficiency of brain-derived neurotrophic factor (BDNF) is involved in the mechanism of depression. The aim of this study is to investigate whether BDNF levels differ between obese female patients and healthy controls and whether BDNF levels alter with affective states in depressive obese women. Methods: The study group included 40 obese, 40 preobese, and 40 normal weight women. BDNF levels were measured with an enzyme-linked immunosorbent assay in patient and control groups. For identifying the depression and anxiety status, Beck Depression/Anxiety Inventories were used; and for the evaluation of cognitive functions, the mini-mental state examination was used. Results: BDNF levels were significantly lower in obese patients compared to the control group (P. 0.01). BDNF levels were significantly lower in obese patients with depression compared to the obese patients without depression (P<0.05). The Beck Depression Inventory showed a negative correlation with BDNF (r=-0.044; P<0.01) and a positive correlation with the Beck Anxiety Inventory (r= 0.643; P<0.001), vitamin B12 levels (r= 0.023; P<0.001), and insulin levels (r= 0.257; P<0.05) in obese patients. When receiver operating characteristic curve analysis was used to analyze the suitability of BDNF to identify depression in obese women, the area under the curve for BDNF, 0.756, was found to be significant (P=0.025). BDNF levels lower than 70.2 pg/mL were associated with a higher prevalence of depressive symptoms. Conclusion: The results of our study suggest that the decrease in BDNF levels can be used as a marker for depression diagnosis in obese patients.
Chemerin and calprotectin levels correlate with disease activity and inflammation markers in psoriasis vulgaris
(Elsevier Taiwan, 2015) Güzel, Savaş; Erfan, Gamze; Kulaç, Mustafa; Güzel, Eda Çelik; Küçükyalçın, Volkan; Kaya, Şule; Kızıler, Ali Rıza
Background: Psoriasis is a chronic inflammatory dermatosis that affects about 2-3% of the general population. We aimed to investigate the relationship between serum chemerin and calprotectin levels and the inflammatory markers that can lead to oxidative damage. Methods: Fifty patients with psoriasis and 30 healthy controls were included in the study. Levels of chemerin and calprotectin were measured in addition to levels of C-reactive protein, the erythrocyte sedimentation rate, and the white blood cell count to evaluate inflammation. Results: According to our findings, chemerin and calprotectin levels in the patient group were significantly higher than in the control group (p <0.01 and p < 0.001. respectively). Patients with psoriasis were divided into three groups based on the Psoriasis Area and Severity Index: mild, moderate, and severe. The chemerin levels in the severe and moderate groups were significantly higher than in the mild group (p < 0.01 and p < 0.05, respectively). The calprotectin levels in the severe psoriasis group were also significantly higher than in the mild group (p < 0.05). Similarly, the erythrocyte sedimentation rate and levels of fibrinogen and C-reactive protein were significantly higher in patients with psoriasis than in the control group (p < 0.05, p <0.01. and p < 0.001, respectively). Stepwise regression analysis was used to assess the individual contributing factors. Among these contributing factors, the chemerin levels were observed to be positively correlated with both the Psoriasis Area and Severity Index (R-2 = 0.111) and the calprotectin level (R-2 = 0.445). Calprotectin was observed to be positively correlated with both the C-reactive protein (R-2 = 0.119) and chemerin levels (R-2 = 0.315). Conclusion: The chemerin and calprotectin levels in patients with psoriasis showed that there is an inflammatory process in psoriasis and that these markers are useful indicators of the severity of psoriasis. (C) Copyright 2014, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC. All rights reserved.
Comparison of the acute alterations in serum bone turnover markers and bone mineral density among women with surgical menopause
(Elsevier, 2011) Bahar, Sengul; Abalı, Remzi; Güzel, Savaş; Bozkurt, Serpil; Güzel, Eda Çelik; Aral, Hale; Boran, Ahmet Birtan
Objective: To determine the effect of a sudden decrease in estrogen levels via bilateral oophorectomy on serum turnover markers and to examine their correlation with bone mineral density (BMD). Study design: This study included 51 women who had regular menses preoperatively and underwent bilateral oophorectomy for benign reasons. These women did not have any systemic disease or drug use that would influence bone metabolism. For each woman, spine and femur BMD were measured preoperatively and sixth months after surgery. Serum C-terminal telopeptide (CTX) and bone alkaline phosphatase (BAP) were measured preoperatively and at the first and sixth months after surgery. Correlations between bone turnover markers and BMD were pre- and post-operatively analyzed. Results: The mean serum CTX and BAP concentrations at the first and sixth postoperative months were significantly higher compared to the preoperative measurements (p = 0.001). Spine BMD values at the sixth postoperative month was significantly lower compared to preoperative period (p = 0.0001). There was a significant negative correlation between spine BMD values and BAP levels both in the preoperative period and at the sixth postoperative month (r = -0.407, p = 0.001), whereas a significant positive correlation between serum CTX and BAP was noted at this time periods (r = 0.615, p < 0.001). Conclusions: The results of this study showed that serum BAP and CTX levels rapidly increase in women after bilateral oophorectomy. Therefore, these markers (especially BAP) could be useful in the evaluation of osteoporosis risk in the early period of surgical menopause. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Copeptin as a Novel Biomarker in Nocturnal Enuresis
(Elsevier Science Inc, 2013) Nalbantoğlu, Burçin; Yazıcı, Cenk Murat; Nalbantoğlu, Ayşin; Güzel, Savaş; Topçu, Birol; Güzel, Eda Çelik; Mintaş, Nuriye Ece
OBJECTIVE To investigate the relation between copeptin, arginine vasopressin (AVP), and nocturnal enuresis (NE). METHODS Forty-four patients with NE and 44 healthy children aged between 6 and 14 years were enrolled. Patients with nonmonosymptomatic and secondary NE were excluded from the study. A small questionnaire, filled by parents, collected information about sociodemographic characteristics. Blood was obtained for plasma AVP and copeptin concentrations. RESULTS Copeptin levels were significantly lower in patient group (3.74 +/- 1.44 pg/mL) than the control group (16.57 +/- 3.91 pg/mL), whereas AVP levels were not significantly different between groups. Copeptin levels were significantly lower in patients (3.17 +/- 1.15 pg/mL) who had bed-wetting 2 or more nights a week, which is considered as severe bed-wetting, than the patients (4.95 +/- 1.24 pg/mL) who had bed-wetting 1 night or less than 1 night a week. CONCLUSION This study demonstrates the presence of decreased levels of copeptin in patients with NE compared with healthy patients. AVP levels were not different between groups. To our knowledge, this is the first report assessing the relationship between copeptin and NE. (C) 2013 Elsevier Inc.
Copeptin as a Novel Biomarker in Nocturnal Enuresis [reply]
(Elsevier Science Inc, 2013) Nalbanto?lu, Burçin; Donma, Mustafa Metin; Özdilek, Burcu; Mintaş, Nuriye Ece; Yazıcı, Cenk Murat; Nalbantoğlu, Ayşin; Güzel, Eda Çelik
[No Abstract Available]
Hipertansif Hastalarda Kognitif Fonksiyonların Değerlendirilmesi ve Serum Midkine Düzeyleriyle İlişkisi
(2017) Güzel, Eda Çelik; Serinkan Cinemre, Fatma Behice; Güzel, Savaş; Kuçukyalcin, Volkan; Kızıler, Ali Rıza; Çavuşoğlu, Coşkun; Aydemir, Birsen
Amaç: Hipertansiyon (HT) demans ile ilişkili risk faktörlerinden biridir. Çalışmanın amacı, HT'lu hastalarda kognitif fonksiyonlar ve serum midkine düzeyleri ile ilişkisini araştırmaktır. Gereç ve Yöntem: Bu çalışmada, 60 yaşın üstünde, en az beş yıllık eğitim alan ve HT tanısı almış 45 hasta ve 30 sağlıklı kontrol incelendi. Hastalara Mini Mental Durum Değerlendirme (MMDD) testi uygulanmıştır. MMDD skoru 24 ve daha düşük olanlar kognitif bozukluk olarak tanımlandı. Bu gruplarda serum midkine seviyeleri değerlendirildi. Bulgular:HT'lu hastalarının MMDD skorları kontrol grubuyla karşılaştırıldı ve anlamlı olarak düşük bulundu (p <0.01). HT'lu hastalarda midkine düzeyleri (25.10 ± 8.16 ng/mL) kontrol grubuyla (19.59 ± 7.53 ng/mL) kıyaslandığında belirgin olarak yüksekti (p <0.01). HT hasta grubunda kognitif bozukluğu olanlar ve olmayanlar arasında Midkine düzeyleri karşılaştıldı. Kognitif bozukluğu olan HT hastalarında Midkine belirgin olarak daha yüksekti (p <0.05). Ayrıca Midkine düzeyleri ile MMDD skorları arasında anlamlı bir negatif korelasyon gözlendi (r = 0.558, p <0.01). Sonuç:Bu çalışma, HT'lu hastalarda artan serum midkine düzeyleri ile kognitif fonksiyon azalması arasında önemli bir ilişki olduğunu göstermiştir.
Immunogenicity after CoronaVac vaccination
(Associacao Medica Brasileira, 2021) Güzel, Eda Çelik; Çelikkol, Aliye; Erdal, Berna; Sedef, N.
OBJECTIVE: This study aimed to investigate the seropositivity of CoronaVac-SinoVac vaccination in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) risk factors and comorbidities. METHODS: Immunoglobulin (IgG) antibody responses were examined on the 21st day after the second dose of CoronaVac-SinoVac 6 ?g vaccine on the 28th day. SARS-CoV-2 IgG antibody levels were measured by using the enzyme-linked immunosorbent assay method in vaccinated health care workers (n=134) (Group I), vaccinated polymerase chain reaction (PCR) (+) who had coronavirus-19 (COVID-19) disease (n=21) (Group II), and unvaccinated PCR (+) (n=28) (Group III) participants. Subgroups were formed in Group I according to the presence of COVID-19 risk factors and comorbidities (diabetes mellitus, cardiovascular disease, and asthma/allergy) and demographic data. RESULTS: Seropositivity rates were 95.5, 100, and 89.3% for Groups I, II, and III, respectively. IgG antibody levels were found significantly higher in the group between the ages of 20–30 in group I compared to those aged 31–50 and over 50 (both p<0.01). It was found significantly higher in normal-weight individuals than in the overweight and obese group (both p<0.01). IgG antibody levels were found significantly lower in people with cardiovascular disease and diabetes mellitus compared with those who did not (p<0.05 and p<0.001, respectively). There was a negative correlation between IgG antibody response values and body mass index and age in Group I (r= -0.336, p<0.001 and r= -0.307, p<0.001, respectively). CONCLUSION: IgG antibody values decrease with age and with increasing body mass index. The presence of comorbidities (i.e., diabetes mellitus and cardiovascular disease) decreased COVID-19 IgG antibody values. © 2021 Associacao Medica Brasileira. All rights reserved.
Indices Used in Differentiation of Thalassemia Trait from Iron Deficiency Anemia in Pediatric Population: Are They Reliable?
(Taylor & Francis Inc, 2012) Nalbanto?lu, Burçin; Güzel, Savaş; Büyükyalçın, Volkan; Donma, Mustafa Metin; Güzel, Eda Çelik; Nalbantoğlu, Ayşin; Özdilek, Burcu
Background: Iron deficiency (IDA) and beta thalassemia trait (TT) are the most common causes of hypochromia and microcytosis. Many indices have been defined to quickly discriminate these similar entities via parameters obtained from automated blood cell analyzers. However, studies in the pediatric age group are scarce and their results are controversial. Methods: We calculated eight discrimination indices [Mentzer Index (MI), England and Fraser Index (E&F), Srivastava Index (S), Green and King Index (G&K), Shine and Lal Index (S&L), red blood cell (RBC) count, RBC distribution width, and red blood cell distribution width Index (RDWI)] in 100 patients. We calculated sensitivity (SENS), specificity (SPEC), positive and negative predictive value (PPV and NPV), and Youden's Index (YI) of each discrimination index. Results: None of the discrimination indices showed a SENS and SPEC of 100%. The highest SENS was obtained with S&L (87.1%), while the highest SPEC was obtained with E&F formula (100%). The highest YI value was obtained with E&F formula (58.1%). Conclusion: In our study, none of the formulas appears reliable in discriminating between TT and IDA patients. The evaluation of iron status and measurement of hemoglobin A(2) (HbA(2)) remain the most reliable investigations to differentiate between TT and IDA patients.
Interleukin-33, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinase-1 in myocardial infarction
(Korean Assoc Internal Medicine, 2013) Güzel, Savaş; Serin, Ozden; Güzel, Eda Çelik; Büyük, Banu; Yılmaz, Guzin; Guvenen, Güvenç
Background/Aims: Acute coronary syndrome (ACS) is characterized by increased inflammatory processes and endothelial activation. We investigated the association between ACS and inflammatory mediators and matrix-degrading enzymes. Methods: We prospectively enrolled 55 consecutive patients with ACS: 25 with unstable angina (UA) and 30 with non-ST elevated myocardial infarction (NSTEMI). For comparison, 25 age- and sex-matched subjects with no significant coronary artery stenosis were included as the control group. Peripheral serum levels of interleukin (IL)-33, matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP-1, and C-reactive protein (CRP) were measured on admission, and at 12, 24, 48, and 72 hours after the initial evaluation. Results: Compared to serum levels in the control group, serum levels of IL-33 decreased in the NSTEMI group (p < 0.05), and levels of MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 increased in the UA group (p < 0.01, p < 0.05, respectively) and NSTEMI group (p < 0.05, p < 0.05, respectively). IL-33 levels were significantly lower on admission than at 12 hours after the initial evaluation (p < 0.05). IL-33 levels were negatively correlated with MMP-9 levels (r = -0.461, p < 0.05) and CRP levels (r = p < 0.05). Conclusions: Elevated levels of MMP-9, TIMP-1, and decreased levels of IL-33 play a role in the development and progression of ACS.
Interleukin-33, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinase-1 in myocardial infarction (vol 28, pg 165, 2013) (Correction)
(Korean Assoc Internal Medicine, 2013) Güzel, Savaş; Serin, Ozden; Güzel, Eda Çelik; Büyük, Banu; Yılmaz, Guzin; Guvenen, Güvenç
[No Abstract Available]
Investigation of Pneumococcus, Influenza, Covid-19 Vaccination Rates and Affecting Factors in Patients aged 65 and over
(2024) Dönmez, Aslıhan Çelik; Güzel, Eda Çelik; Topçu, Birol
Objective: This study was planned to determine the vaccination rates and related factors with Pneumococcal, Influenza and Covid-19 vaccines in adults aged 65 and over who applied to the Family Medicine Outpatient Clinic. Methods: The sample of the descriptive study consisted of 200 volunteer adult patients aged 65 and over who applied to the Family Medicine outpatient clinic between May and October 2021. The data were collected by applying a face-to-face interview with descriptive features. Results: The mean age of the participants was 71.21±5.97 years. Influenza vaccination rate of all participants in the last 1 year was 24.50%, Pneumococcal vaccination rate in the last 5 years was 42%, and Covid-19 vaccination rate was 86%. In our study, having a chronic disease was the factor that increased the rate of influenza vaccination, it was determined that the factor determining the pneumococcal vaccination rate was affected by the habit of going to the family doctor regularly (p<0.05). Individuals who did not receive the Covid-19 vaccine stated that they did not have the vaccine because they were afraid of the side effects of the vaccine and did not find the vaccine safe. Conclusions: Our study revealed that adult vaccination rates are low and they do not have enough information about their vaccinations. Health professionals, especially family physicians, have important duties to determine the factors affecting the level of knowledge about immunization in adults, to increase awareness and to make preventive medicine reach more people.
Maligniteyi Saptamak için Gaitada Gizli Kan Testi Ne Kadar Etkilidir?
(2022) Şahin, Tarık Ahmet; Güzel, Eda Çelik; Mete, Rafet
Amaç: Kanser, kalp damar hastalıklarından sonra ikinci önde gelen ölüm nedeni ve önemli bir halk sağlığı sorunudur. Aile hekimliği polikliniğine başvuran hastalarda periyodik sağlık muayenesi (PSM) kapsamında istenen gaitada gizli kan test (GGKT) pozitifliklerinde kolorektal kanser (KRK) görülme sıklığını ortaya koymayı amaçladık. Gereç ve Yöntem: Çalışmaya bir üniversite hastanesinin aile hekimliği polikliniğine genel sağlık kontrolü için başvuran 50-70 yaş arasındaki 119 kişi dahil edildi. Katılımcılara sosyo-demografik verilerin ve KRK risk faktörlerinin sorgulandığı bir anket uygulandı. Hastaların hemogram, GGKT, kolonoskopi sonuçları ve patoloji sonuçları değerlendirildi. Bulgular: Araştırmaya katılan 119 kişinin 62’si (%52,1) kadın, 57’si (%47,9) erkekti. Katılımcıların yaş ortalaması 61,0±7,6 yıl idi. Tüm katılımcılardan 65 kişinin (%54,6) GGTK’i pozitif saptandı. Araştırmaya katılan 5 kişiye (%4,2) kolonoskopi işleminde alınan biyopsi sonuç raporlarına göre KRK tanısı konuldu. KRK tanısı konan 5 kişinin GGKT sonucu pozitif olup, GGKT pozitif çıkan tüm hastalardaki malignite saptanma oranı, araştırmamızda %7,7 (n=5) olarak bulundu. Çalışmamızda GGKT pozitifliği ve KRK tanısı arasında istatistiksel olarak anlamlı bir ilişki saptandı. Sonuç: Birinci basamak PSM kılavuzlarının uygun önerileri doğrultusunda ve risk düzeyi yüksek olan bireylerde KRK taramalarında, GGKT erken tanı koyması ve en kısa sürede tedaviye yönlendirmesine katkı sağlamaktadır.
Midkine Levels and its Relationship with Atherosclerotic Risk Factors in Essential Hypertensive Patients
(Wolters Kluwer Medknow Publications, 2018) Güzel, Savaş; Cinemre, Fatma Behice Serinkan; Güzel, Eda Çelik; Küçükyalçın, Volkan; Kızıler, Ali Rıza; Çavuşoğlu, Coşkun; Aydemir, Birsen
Background and Objectives: Hypertension (HT) is one of the risk factors associated with atherosclerosis. Midkine (MK) plays a role as a growth factor in various biologic and pathologic events. In some reports, MK expression has been shown to be linked with vascular smooth muscle proliferation and neo-angiogenesis in atherosclerotic vessels. The aim was to research relationship of MK serum levels with some atherosclerotic risk factors in hypertensive patients. Methodology: This study examined 60 patients with essential HT and 30 healthy controls. Serum biochemistry, including lipid profile, MK, Vitamin B 12, C-reactive protein, zinc and copper levels were obtained. Results: MK levels of the HT patients were significantly higher than the control group (24.8 +/- 6.8 ng/mL vs. 18.39 +/- 5.6 ng/mL, respectively, P < 0.01). Lipid profile parameters such as total cholesterol, triglyceride, low-density lipoprotein (LDL) were also significantly higher in HT patients (P < 0.021, P < 0.01, and P < 0.01, respectively). Zinc levels were 179.13 +/- 34.06 mu g/dL and 172.55 +/- 45.47 mu g/dL in the HT and control group, respectively. Serum MK levels were positively correlated with diastolic (r = 0.288, P < 0.05) and systolic blood pressures (r = 0.390, P < 0.002), and also with serum total cholesterol (r = 0.406, P < 0.002) and LDL cholesterol (r = 0.318, P < 0.015) levels. Furthermore MK was also negatively correlated with zinc and Vitamin B 12 levels (r = -0.298, P < 0.023, r = -0.334, P < 0.027, respectively). Conclusion: This study has demonstrated an important association between increased serum MK levels and risk factors of atherosclerosis such as HT, increased total and LDL cholesterol.

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