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Öğe Evaluation of epicardial adipose tissue and carotid intima-media thickness as a marker of atherosclerosis in patients with inflammatory bowel disease(ARAN Ediciones S.A., 2021) Ekmen, Nergiz; Can, G.; Yozgat, A.; Can, Hamit; Bayraktar, M.F.; Demirkol, MuhammetE.; Sasani, HadiBackground and aim: this study aimed to compare carotid intima media (CIMT) and epicardial adipose tissue (EAT) measurements, which are considered as markers for the detection of early atherosclerosis in healthy controls and inflammatory bowel disease (IBD) cases. Methods: a total of 60 IBD patients (25 Crohn’s disease and 35 ulcerative colitis) and 60 healthy patients (as a control group) were included in the study. The measurements of CIMT and EAT were performed using echocardiography and ultrasonography, respectively. Statistical analysis was used to determine the relationship between the parameters. Results: the thickness of bilateral (right and left) CIMT and EAT were significantly higher in IBD than in the control group (p < 0.05). There was a positive correlation between EAT and bilateral (right and left) CIMT in IBD patients (p < 0.05). Conclusion: IBD is associated with an increased thickness of EAT and CIMT. Chronic inflammation in IBD may increase the risk of atherosclerotic heart disease. Thus, only measuring the thickness of EAT and CIMT can be used as an objective, easy, simple, affordable, non-invasive and accessible assessment method in order to screen for this risk. © Copyright 2021. SEPD y © ARÁN EDICIONES, S.L.Öğe Evaluation of the Effects of COVID-19 Pandemic Among Patients with Inflammatory Bowel Diseases(2020) Gökden, Yasemin; Ekmen, Nergiz; Adaş, Mine; Atak, Süheyla; Sasani, HadiObjective: The Coronavirus Disease-2019 (COVID-19) pandemic continues to be a concern, especially to people with chronic diseases across the entire world. During this pandemic, we undertook an investigation to assess how the disease state and medical treatments of inflammatory bowel disease (IBD) are affecting the IBD patients, their risky perceptions, as well as the frequency and course of COVID-19. Methods: During the pandemic, the information on the course of the disease, medical treatment status of the patients with IBD, and the course of the disease in IBD patients who had COVID-19 were collected via telephonic interview. Results: A total of 102 IBD patients, including 62 with ulcerative colitis and 40 with Crohn’s disease were included in the study. Of these, 52.9% of the patients believed that having IBD was a risk for COVID-19. During the pandemic, 18.6% of the patients did not take their medication regularly for various reasons. Of all, 64.28% of the patients with active disease could not go to the hospital to avoid the risk of acquiring COVID-19 and 4.90% acquired COVID-19. Conclusion: During the pandemic, both the regular consumption of medicines and the reservations regarding admission to hospitals affect the course of IBD. Therefore, the development of strategic action plans to support and manage changes experienced during the course of this disease is expected to facilitate the management of the disease process in a healthier way for both the physicians and the patients.Öğe Is there any link between atrial arrhythmias and inflammatory bowel disease?(Wolters Kluwer Medknow Publications, 2021) Can, G.; Ekmen, Nergiz; Can, Hamit; Bayraktar, M.F.; Demirkol, MuhammetE.; Kayhan, M.A.; Sasani, HadiBackground: Inflammation plays an important role in the development of cardiovascular disease, including atherosclerosis and arrhythmia. The aim of this study was to evaluate atrial conduction times (ACTs) in patients with inflammatory bowel disease (IBD) in which systemic chronic inflammation is evident. Methods: In this cross-sectional, prospective, single-center study, 79 IBD patients (51 ulcerative colitis; 28 Crohn's disease) and 70 healthy controls were included. Atrial electromechanical properties were measured by recording simultaneous surface electrocardiography (ECG) with transthoracic echocardiography (ECHO) and tissue Doppler imaging methods. The relationship between age, disease duration, and ACT was evaluated. Results: There were significantly increased conduction durations of lateral-PA (time interval from the onset of the P-wave on surface ECG to the beginning of the late diastolic wave), septal-PA, tricuspid-PA, and interatrial-electromechanical delay (IA-EMD), right intraatrial EMD, and left intraatrial (LI-EMD) durations in IBD patients (P < 0.001). In IBD patients, there was a positive correlation with age, lateral PA, septal PA, tricuspid PA, IA-EMD, and LI-EMD (P < 0.05). A positive correlation was found between disease duration and only lateral PA and tricuspid PA (P < 0.05). Conclusion: In IBD patients, prolonged ACT consists a potential risk for severe atrial arrhythmias. ECG and ECHO screening can be useful in identifying risk groups in IBD patients and taking precautions for future cardiac complications. © 2021 Saudi Journal of Gastroenterology Published by Wolters Kluwer - Medknow.Öğe Multiorgan failure due to strongyloides infection in liver transplant recipient: A case report and literature review(Ondokuz Mayis Universitesi, 2022) Ekmen, Nergiz; Bilger, Nirgül; Kirman, Derya; Sasani, HadiStrongyloidasis is caused by an intestinal nematode Strongyloides stercoralis which is widely distributed in tropical and subtropical countries. In immunocompetent individuals, Strongloides stercoralis infection usually does not produce any symptoms or causes gastrointestinal, cardiopulmonary, or skin symptoms. However, in some patients especially immunsupressive (e.g post-transplant, taking exogenous corticosteroids), its infection associated with severe and life-threatening disease like hyperinfection syndrome and disseminated tissue infestation. The limitation of diagnostic test make it challenging to diagnose strongyloidasis. Therefore, it is important to suspect infection of Strongyloides stercoralis. We describe a case of Strongiloides infection with a fatal outcome in liver transplant recipient. © 2022 Ondokuz Mayis Universitesi. All rights reserved.Öğe Relationship between pruritus and autotaxin in intrahepatic cholestasis of pregnancy(Ediciones Doyma, S.L., 2021) Çifçi, S.; Irak, K.; Bayram, M.; Ekmen, Nergiz; Kazezoglu, C.; Acar, Zeynep; Sasani, HadiObjective: Intrahepatic cholestasis of pregnancy is a temporary, pregnancy-specific disease that resolves with delivery, characterized by itching (pruritus), as well as high transaminase and serum bile acid levels in the third trimester of pregnancy. Due to the effects of Autotaxin on the physiology of pregnancy, we aimed to investigate Autotaxin activity in patients with intrahepatic cholestasis of pregnancy. Patients and methods: Sixty-nine patients diagnosed with intrahepatic cholestasis of pregnancy and 20 healthy pregnant women were enrolled in the study. Fasting serum bile acid, pruritus intensity, serum parameters, gestational week of the patients at the time of diagnosis were recorded, and birth week and birth weight were monitored. Autotaxin serum level was measured enzymatically. Results: The mean serum bile acid level (n = 69; 38.74 ± 35.92 ?mol/L) in patients with intrahepatic cholestasis of pregnancy (n = 69) was detected to be higher than healthy pregnant women (n = 20; 5.05 ± 1.88 ?mol/L) (p < 0.001). Weak correlation was detected between serum bile acid level and itch intensity (p = 0.014, r = 0.295), while no relation was detected between Autotaxin and itch intensity (p = 0.446, r = 0.09). Although mean Autotaxin (intrahepatic cholestasis of pregnancy: 678.10 ± 424.42 pg/mL, control: 535.16 ± 256.47 pg/mL) levels were high in patients with intrahepatic cholestasis of pregnancy, it was not statistically significant (p = 0.157). Conclusion: In our study, we observed that the serum Autotaxin level did not make a significant difference in patients with intrahepatic cholestasis of pregnancy compared to healthy pregnant women. These findings suggest that larger clinical studies are required to reveal the physio-pathological effects of Autotaxin on pregnancy. © 2020 Elsevier España, S.L.U.
