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Öğe Comparative Investigation of Anti-Inflammatory Effect of Platelet-Rich Fibrin after Mandibular Wisdom Tooth Surgery: A Randomized Controlled Study(Mdpi, 2023) Karaca, Gamze Tanan; Duygu, Gonca; Er, Nilay; Ozgun, ErayThis study evaluated the anti-inflammatory effect of platelet-rich fibrin (PRF) applied to the extraction socket after impacted mandibular third molar surgery with subjective and objective parameters. Forty-eight patients with impacted wisdom teeth in bilateral and similar positions were included in the study. The control group was formed with the standard surgery and the PRF group was formed with local PRF application in addition to standard procedure (n = 96). The anti-inflammatory activity of PRF on postoperative 2nd and 7th days was evaluated subjectively by clinical parameters and objectively by biochemical parameters. Postoperative 2nd- and 7th-day follow-up data of pain, edema, and trismus in the PRF group were found to be statistically significantly lower. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were found to be statistically significantly lower in the PRF group than the control in the postoperative 2nd-day follow-up period (p < 0.001). There was no statistically significant difference in interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-& alpha;) parameters when the PRF group and the control group were compared in both follow-up periods (p > 0.05). The study has demonstrated the effectiveness of locally applied PRF after ITM surgery via clinical parameters and objective data. The quantitative analysis of CRP and ERS can be an effective parameter in determining the amount of inflammation after ITM surgery.Öğe Could Local Application of Hypoxia Inducible Factor 1-alpha Enhancer Deferoxamine Be Promising for Preventing of Medication-Related Osteonecrosis of the Jaw?(Mdpi, 2023) Yalçın-Ülker, Gül Merve; Günbatan, Murat; Duygu, Gonca; Soluk-Tekkesin, Merva; Özçakir-Tomruk, CeydaThis experimental study investigates the prophylactic effect of deferoxamine (DFO) on medication-related osteonecrosis of the jaw (MRONJ). Thirty-six female Sprague Dawley rats received zoledronic acid (ZA) for eight weeks to create an osteonecrosis model. DFO was locally applied into the extraction sockets with gelatin sponge (GS) carriers to prevent MRONJ. The specimens were histopathologically and histomorphometrically evaluated. Hypoxia-inducible factor 1-alpha (HIF-1 alpha) protein levels in the extraction sockets were quantified. New bone formation rate differed significantly between groups (p = 0.005). Newly formed bone ratios in the extraction sockets did not differ significantly between the control group and the GS (p = 1), GS/DFO (p = 0.749), ZA (p = 0.105), ZA-GS (p = 0.474), and ZA-GS/DFO (p = 1) groups. While newly formed bone rates were higher in the ZA-GS and ZA-GS/DFO groups than in the ZA group, the differences were not significant. HIF-1 alpha levels differed significantly between groups (p < 0.001) and were significantly higher in the DFO and ZA-GS/DFO groups than in the control group (p = 0.001 and p = 0.004, respectively). While HIF-1 alpha levels were higher in the ZA-GS/DFO group than in the ZA group, the difference was not significant. While HIF-1 alpha protein levels and new bone formation rate were elevated in the DFO-treated group, the effect was not significant. Further large-scale studies are needed to understand DFO's preventative effects on MRONJ and the role of HIF-1 alpha in MRONJ pathogenesis.Öğe Does Saline Irrigation at Different Temperatures Affect Pain, Edema, and Trismus After Impacted Third Molar Surgery: A Clinical Trial(W B Saunders Co-Elsevier Inc, 2023) Çanakçı, F. Gülfesan; Er, Nilay; Duygu, Gonca; Karaca, Gamze TananPurpose: Lower impacted third molar surgery is a very common oral-maxillofacial surgical procedure, which has complications such as facial swelling, pain, and trismus. This clinical trial aimed to compare the intensity of postoperative morbidity (pain, facial swelling, and trismus) following the third molar surgery performed using saline irrigation at different temperatures (4 degrees C, 10 degrees C, or 25 degrees C).Materials and Methods: This double-blind, single-center, split-mouth, randomized prospective clinical trial was conducted among 48 systemically and periodontally healthy patients who had bilaterally asymp-tomatic mandibular third molars. Patients were randomly allocated into 2 groups (n = 24) according to the temperature of the saline used. In each patient, one impacted third molar was determined as the test group (4 degrees C or 10 degrees C saline irrigation) and the other impacted third molar as the control group (25 degrees C saline irri-gation). Trismus and swelling were evaluated on the 1st, 3rd, and 7th days postoperatively. Pain perception by visual analog scale (VAS) and the total number of analgesics taken during the 7 postoperative days were recorded. Data were analyzed using the Shapiro-Wilk test, the chi-square test, one-way analysis of variance, Duncan test, the Kruskal-Wallis test, the Dunn test, and the Friedman test (P < .05).Results: Forty-eight patients (28 females, 20 males) with a mean age of 24.6 +/- 3.8 years were included in the study. The duration of operations was similar. VAS values of test groups [test group 1 (4 degrees C): 4.0, test group 1 (10 degrees C): 8.0] and the number of analgesics taken [test group 1 (4 degrees C): 0, test group 1 (10 degrees) C): 3] were significantly lower (P < .001) than control groups (VAS, control group 1: 13.0, control group 2: 15.5, number of analgesic taken, control group 1: 5.5, control group 2: 4.0). Significant differences were found between the test groups in VAS values and the number of analgesics taken (P < .001). Also, the lowest trismus and facial swelling values were detected in the 4 degrees C test group at all time points (P < .001). Conclusion: In the impacted third molar surgery, the use of cooled saline irrigation during bone removal may be a simple, inexpensive, and effective method for reducing early postoperative complaints. (c) 2022 American Association of Oral and Maxillofacial SurgeonsÖğe Evaluation of Preventive Role of Systemically Applied Erythropoietin after Tooth Extraction in a Bisphosphonate-Induced MRONJ Model(Mdpi, 2023) Duygu, Gonca; Yalcin-Ulker, Guel Merve; Gunbatan, Murat; Soluk-Tekkesin, Merva; Ozcakir-Tomruk, CeydaBackground and Objectives: In this experimental study, the prophylactic effect of systemically administered erythropoietin (EPO) in medication-related osteonecrosis of the jaw (MRONJ) was evaluated. Materials and Methods: The osteonecrosis model was established using 36 Sprague Dawley rats. EPO was systemically applied before and/or after tooth extraction. Groups were formed based on the application time. All samples were evaluated histologically, histomorphometrically, and immunohistochemically. A statistically significant difference in new bone formation was observed between the groups (p < 0.001). Results: When new bone-formation rates were compared, no significant differences were observed between the control group and the EPO, ZA+PostEPO, and ZA+Pre-PostEPO groups (p = 1, 0.402, and 1, respectively); however, this rate was significantly lower in the ZA+PreEPO group (p = 0.021). No significant differences in new bone formation were observed between the ZA+PostEPO and ZA+PreEPO groups (p = 1); however, this rate was significantly higher in the ZA+Pre-PostEPO group (p = 0.009). The ZA+Pre-PostEPO group demonstrated significantly higher intensity level in VEGF protein expression than the other groups (p < 0.001). Conclusions: Administering EPO two weeks pre-extraction and continuing EPO treatment for three weeks post-extraction in ZA-treated rats optimized the inflammatory reaction, increased angiogenesis by inducing VEGF, and positively affected bone healing. Further studies are needed to determine the exact durations and doses.Öğe Surgical management of stage-2 medication-related osteonecrosis of the jaw with transplantation of human amniotic membrane: Preliminary results(Elsevier Masson s.r.l., 2022) Çanakçı, F.Gülfeşan; Er, Nilay; Duygu, Gonca; Varol, G.FüsunMedication-related osteonecrosis of the jaw (MRONJ) is a drug adverse reaction. Seven osteonecrosis areas in 5 cases were treated with stage-2 MRONJ using human amniotic membrane (HAM) transplantation after sequestrectomy. Patients were evaluated in terms of infection (pain, erythema, and pus), mucosal coverage, and pain at 1, 2, 4, 8, and 12 weeks. Patients who showed improvement (total mucosal coverage, no sign of infection and pain) at the end of 12 weeks were followed up every 8 weeks. Also, radiographic examinations (panoramic radiography at every 8 weeks, cone-beam computed tomography at every 6 months) were performed to evaluate bone destruction. Complete mucosal closure was achieved in 6 necrosis sites. In only 1 patient, mucosal coverage was not achieved. No pain and infection relapse were observed during the follow-ups. HAM might be an effective material in terms of soft tissue healing and elimination of pain and infection for stage-2 MRONJ. Clinical Trials Registration Number: NCT04967963 © 2021Öğe Tekirdağ Bölgesindeki Bireylerde Dişlerin Gömülü Kalma Sıklığının Belirlenmesi(2024) Kaplan, Volkan; Duygu, Gonca; Erener, HandeAmaç: Dişler, süremediklerinde veya gelişmediklerinde farklı şekillerde gömülü kalabilirler. Bu çalışmada, gömülü dişlerin pozisyonlarının ve görülme sıklığının değerlendirilmesi amaç- lanmıştır. Gereç ve Yöntem: Tekirdağ Namık Kemal Üniversitesi Ağız ve Diş Sağlığı Uygulama ve Araştırma Merkezi’ne ilk defa baş- vuran 18 yaş ve üzeri 400 hastanın panoramik radyografları incelenmiştir. Hastaların gömülü diş lokalizasyonları ve po- zisyonları belirlenmiştir. Cinsiyet ve yaş değişkenlerine göre çalışmadan elde edilen veriler görülme sıklığı açısından de- ğerlendirilmiştir. Bulgular: Yaşları 18-80 yaş arasında değişen (ortalama: 40,15±15,42) 400 hastanın, 175’i kadın (%43,75), 225’i erkekti (%56,25). Gömülü diş oranı %38 olarak tespit edilmiştir. Gömü- lü dişlerin cinsiyetlere göre dağılımları arasında istatistiksel olarak anlamlı fark bulunmamıştır. Hastalar yaşa göre 4 gru- ba (18-30, 31-40, 41-50 ve 51 yaş ve üzeri olmak üzere) ayrıl- mıştır. Gömülü dişlerin yaşlara göre dağılımı incelendiğinde gruplar arasında istatistiksel olarak anlamlı fark bulunmuştur (p<0,001). Gömülü dişlerin görülme sıklığı sırasıyla mandibu- lar üçüncü molar, maksillar üçüncü molar ve maksillar kanin dişler olarak tespit edilmiştir. Sonuçlar: Bu çalışma sonucunda literatürdeki oranların orta- lamasına uygun olarak gömülü diş insidansı %38 olarak tespit edilmiştir. Bu oran bölgedeki bireylerde gömülü diş varlığının azımsanmayacak oranda yüksek olması sebebiyle yetişkin bireylerin ağız ve diş sağlığı tedavi/kontrollerinde gömülü diş varlığı açısından da değerlendirilmeleri gerektiğini göster- mektedir.Öğe The effect of local application of thymoquinone, Nigella sativa?s bioactive component, on bone healing in experimental bone defects infected with Porphyromonas gingivalis(Korean Acad Periodontology, 2022) Baştuğ, Ayşe Yılmaz; Tomruk, Ceyda Özçakir; Güzel, Elif; Özdemir, İlkay; Duygu, Gonca; Kütan, Esma; Arıcı, Fatma ÖzenPurpose: This study was performed to evaluate the influence of local application of thymoquinone (TQ) on bone healing in experimental bone defects infected with Porphyromonas gingivalis (PG). Methods: Forty-two female rats were randomly divided into 6 groups. A bone defect was created on the right tibia of all animals. The PG, PG/collagen membrane (COL) and PG/ TQ/COL groups were infected with PG. In the COL and PG/COL groups, the defects were covered with a COL; in the TQ/COL and PG/TQ/COL groups, the defects were covered with a TQ-containing COL. After 28 days, all animals were sacrificed. Quantitative measurements of new bone formation and osteoblast lining, as well as semiquantitative measurements of capillary density and tissue response, were analyzed. Furthermore, the presence of bacterial infections in defect areas was evaluated. Results: The new bone formation, osteoblast number, and capillary density were significantly higher in the TQ groups than in the control groups (P<0.001, P<0.001, and P<0.01, respectively). In a comparison between the TQ/COL group, with a TQ-containing COL (TQ/COL), and the PG-infected TQ-containing COL (PG/TQ/COL) group, the newly formed bone and capillary density were higher in the TQ/COL group (P<0.01). When the control group was compared to the PG, PG/COL, and PG/TQ/COL groups in terms of tissue response, the differences were statistically significant (P<0.001, P=0.02, and P=0.041, respectively). The intensity of the inflammatory cell reaction was higher in the PG, PG/COL, and PG/TQ/COL groups (P<0.05). Conclusions: Within the limitations of this study, the local application of a TQ-containing COL positively affected bone healing even if the bone defects were infected. The results suggest that TQ increased angiogenesis and showed promise for accelerating bone defect healing. Further research is warranted to support these findings and reach more definitive conclusions.Öğe Use of Leukocyte-rich and Platelet-rich Fibrin (L-PRF) Adjunct to Surgical Debridement in the Treatment of Stage 2 and 3 Medication-Related Osteonecrosis of the Jaw(Lippincott Williams & Wilkins, 2023) Yalcin-Ulker, Gul Merve; Duygu, Gonca; Tanan, Gamze; Cakir, Merve; Meral, Deniz GokceMedication-related osteonecrosis of the jaw (MRONJ) is characterized by exposed necrotic bone persisting for more than 8 weeks in the maxillofacial region in patients using antiresorptive or antiangiogenetic drugs for several treatment options like bone metastasis or osteoporosis. There are several treatment options studied in scientific literature, and one of them with promising results is using platelet concentrates adjunct to surgical therapy. The aim of this study is to examine the therapeutic effect of leukocyte and platelet-rich fibrin (L-PRF) on patients with MRONJ. This 2-centered study investigated patients referred to oral and maxillofacial surgery departments of 2 university clinics between the years 2014 and 2020 with the diagnosis of MRONJ. Demographic data, the indication of the drug usage, drug type, duration, administration route, and systemic comorbidities of the patients were recorded. L-PRF was applied to 20 osteonecrotic lesions of 19 patients following surgical debridement. The male/female ratio was 5/14. Except 1 of the patients, all of the indications of medication were neoplasia-related. The mean follow-up period of patients was 27.9 & PLUSMN;9.2 months. Most common antirezorptive drug was zoledronate (84.2%). Complete resolution was observed in 16 necrosis sites (80%). It could be concluded that the use of L-PRF may represent an important adjunct in the surgical management of MRONJ.Öğe YouTube videolarının dental implant içeriği hastalara faydalı mı?(2024) Duygu, GoncaAmaç: Bu çalışmanın amacı, hastalar için bilgi kaynağı olan dental implant konulu YouTube videoların içeriğinin, yararlılı- ğının, güvenilirliğinin ve kalitesinin analiz edilmesidir. Gereç ve Yöntem: Dental implant için 3 farklı anahtar kelime olan “diş implantı”, “çene implantı” ve “implant tedavisi” ile 3 grup oluşturuldu. Her grup için ilk 60 video izlendi. Videola- rın toplam izlenme sayısı, video süresi, “beğenme”, yüklenme sonrası geçen gün, yükleme kaynağı ve izlenme oranı kayde- dildi. Yüklenme kaynağı, hedef kitle ve bilgiyi verene göre vi- deolar sınıflandırıldı. Videoların içeriklerine göre oluşturulan yararlılık skoru, video içeriği zayıf (0-2 puan), orta (3-5 puan) ve iyi (6-8 puan) olarak kategorize edildi. Güvenilirlik açısın- dan DISCERN değeri 0 ile 5 puan arasında, kalite açısından GQS değeri 1 ile 5 arasında puanlandı. Bulgular: Diş implantı grubunda 44, çene implantında 33 ve implant tedavisinde 32 olmak üzere toplamda 109 video de- ğerlendirildi. Tüm videolar için yararlılık skoru ortalama değeri 3,34 olarak, DISCERN skoru ortalama değeri 1,93 olarak, GQS skoru ortalama değeri ise 2,44 olarak kaydedildi. Yararlılık skoru kategorilerine göre video sürelerinin ortalama değerleri arasında istatistiksel olarak anlamlı bir farklılığın olduğu göz- lendi (p=0,033). Sonuç: Bu çalışmanın sonuçları dental implant ile ilgili vide- oların %50,4'ünün düşük kalite puanına sahip olduğunu gös- termiştir. YouTube'un bilgi kaynağı olarak kullanılmasının uy- gun olmadığı sonucuna varılabilir.
