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Öğe Carbonic anhydrase I and II autoantibody levels in primary hypertension: Our preliminary results(Verduci Editore s.r.l, 2021) Kara, Sonat Pınar; Özkan, Gülsüm; Emeksiz, Kübra; Menteşe, A.; Demir, S.; Ulusoy, S.OBJECTIVE: The pathogenesis of primary hypertension (HT) is still not completely clear, although autoimmunity has been implicated in recent years. Carbonic anhydrase (CA) is an enzyme involved in a number of important metabolic processes. CA I and II autoantibodies have been linked to various autoimmune diseases. However, CA I and II autoantibody levels in primary HT have not been previously investigated. The purpose of this study was, therefore, to investigate levels of CA I and II autoantibodies in primary HT. PATIENTS AND METHODS: Fifty-six patients newly diagnosed with primary HT and 33 healthy individuals were included in the study. Twenty- four-hour ambulatory blood pressure monitoring was performed following office controls. Blood specimens were collected under appropriate conditions for CA I and II autoantibody level investigation and biochemical tests. Urine sodium and protein excretion were measured after 24 h. Demographic and biochemical parameters and CA I and II autoantibody levels were then compared between the patient and healthy groups. RESULTS: CA II autoantibody and uric acid levels were significantly higher in the hypertensive group than in the control group (p=0.005, and p<0.001, respectively). CA II autoantibody (exp ß: 79.06 CI: 4.44-1407.02) (p=0.003) and uric acid elevation (exp ß: 2.10 CI: 1.31- 3.34) (p=0.002) were identified as independent predictors of HT development at logistic regression analysis. CONCLUSIONS: CA II autoantibody levels were higher in hypertensive patients, and this elevation is an independent predictor of HT development. © 2020 Verduci Editore s.r.l. All rights reserved.Öğe Clinical results of chromosome 15 copy number variations(Springernature, 2020) Gürkan, H.; Atlı, E.; Yalçıntepe, S.; Atlı, E.; Demir, S.; Özen, Y.; Tozkır, Hilmi[No Abstract Available]Öğe In vitro ruminal fermentation and nutrient compositions of potato starch by-products(Kielanowski Inst Animal Physiology Nutrition, 2023) Kara, K.; Ozkaya, S.; Guclu, B. K.; Aktug, E.; Demir, S.; Yilmaz, S.; Pirci, G.The purpose of the present study was to determine the chemical composition and in vitro ruminal fermentation capacity of potato pulp (PP), potato pulp with peel (PPp) and potato peel (Pp), i.e. potato starch by-products. PP and PPp were applied at 5.0, 7.5 and 10.0% (on a dry matter basis) instead of corn flake and barley grain in dairy cow total mixed ration (TMR). The volumes of in vitro total gas and methane production, and metabolisable energy (ME) values of PP and PPp were higher compared to Pp (P < 0.001). The in vitro true dry matter digestion (tDMd) and in vitro true organic matter digestion (tOMd) values of PP using at 7.5% and 10% rates in TMR were decreased linearly according to that of control TMR value (P < 0.05). Therefore, the use of potato starch by-products in ruminant diet can be suggested due to the high and rapid fermentation potential, especially of potato pulp without peel. The study showed that PP could be applied at up to 5% and PPp at a level of up to 10% in dairy cattle TMR (on a DM basis). Further in vitro studies should be carried out using dried potato starch by-products.
