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Öğe Comparison of GnRH agonist and antagonist protocols in stage III-IV endometriosis patients who underwent endometrioma resection surgery(Oxford Univ Press, 2013) Bastu, Ercan; Mutlu, Mehmet Burak; Çelik, Cem; Yasa, Cenk; Dural, O.; Buyru, Faruk[No Abstract Available]Öğe Comparison of Ovulation Induction Protocols After Endometrioma Resection(Soc Laparoendoscopic Surgeons, 2014) Bastu, Ercan; Yasa, Cenk; Dural, Özlem; Mutlu, Mehmet Firat; Çelik, Cem; Uğurlucan, Funda Güngör; Buyru, FarukBackground and Objectives: The aim of this study was to compare the in vitro fertilization (IVF) outcomes of long gonadotropin-releasing hormone agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) protocols in endometriosis patients who have undergone laparoscopic endometrioma resection surgery. To our knowledge, there is no study in the current literature that compares the effectiveness of long GnRH-a and GnRH-ant protocols in management of IVF cycles in endometriosis patients who underwent laparoscopic endometrioma resection surgery. Methods: Eighty-six patients with stage III to IV endometriosis who had undergone laparoscopic resection surgery for endometrioma were divided into 2 groups: those who had ovarian stimulation with a long GnRH-a protocol (n = 44), and those who had ovarian stimulation with a GnRHant protocol (n = 42). Results: The number of follicles on human chorionic gonadotropin injection day, duration of hyperstimulation, number of retrieved metaphase II oocytes, and total number of grade 1 embryos were statically significantly higher in the long GnRH-a protocol. There were no significant differences in positive beta-human chorionic gonadotropin pregnancy rates (25% vs 21.4%; P = .269) and ongoing pregnancy rates per patient (20.5% vs 19.1%; P = .302) between the 2 protocols. Conclusions: Long GnRH-a and GnRH-ant protocols both present similar IVF outcomes in patients with endometriosis who have undergone laparoscopic endometrioma resection surgery. A long GnRH-a protocol may lead to a higher number of embryos that can be cryopreserved, providing the possibility of additional embryo transfers without having to go through the process of ovarian stimulation again.Öğe Evaluation of embryo transfer time (day 2 vs day 3) after imposed single embryo transfer legislation: When to transfer?(Informa Healthcare, 2013) Bastu, Ercan; Çelik, Cem; Keskin, G.; Buyru, FarukTo determine whether the timing of embryo transfer (day 2 or day 3) affects pregnancy outcome in IVF patients, receiving single or double embryo transfer, 380 patients were included in this retrospective study. All patients underwent GnRH antagonist protocol. When stratified by number of transferred embryos, single embryo transfer (SET) patients undergoing a day 2 embryo transfer (ET) had similar biochemical pregnancy (25% vs 20.4%; p > 0.05) and clinical pregnancy (16.6% vs 14.6%; p > 0.05) rates to SET patients that were undergoing a day 3 ET. A similar observation was again noted in double embryo transfer (DET) patients undergoing a day 2 ET, with similar biochemical pregnancy (35% vs 29.8%; p > 0.05) and clinical pregnancy (25% vs 15.5%; p > 0.05) rates to DET patients undergoing a day 3 ET. Women, despite age, number of transferred embryos and ET timing, have similar reproductive outcomes. Shortening or lengthening the duration of in vitro culture provides no obvious benefit.Öğe Reproductive and metabolic effects of exogenous administration of irisin versus physical activity in high-fat diet-fed female mouse model(Oxford Univ Press, 2015) Bastu, Ercan; Zeybek, U.; Dural, O.; Çelik, F.; Yüksel, B.; Okumuş, N.; Buyru, Faruk; Çelik, Cem[No Abstract Available]
