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Öğe Association between C-peptide level and microalbuminuria in patients with type 2 diabetes mellitus(Cukurova Univ, Fac Medicine, 2018) Boyuk, Banu; Okuturlar, Yıldız; Uludag, Erdoğan; Atalay, Hande; Güzel, Savaş; Çelebi, AslanPurpose: Latest studies suggest that C-peptide may have a beneficial biological role on diabetic nephropathy. The aim of this study is to analyze whether there is an association between serum C-peptide level and microalbuminuria in type 2 diabetes mellitus (T2DM). Materials and Methods: We enrolled 184 T2DM patents and 46 healthy subjects in this study. Clinical variables and routine biochemical tests along with serum C peptide levels measured after an overnight fasting. Serum C peptide levels between 1.1 and 4.4 accepted as normal. 24-hour-urine samples were investigated and values between 30-300mgwere recorded as microalbuminuria. Pearson correlation analysis were used to determine associations between continuous variables. Results: C peptide levels were not significantly difference in T2DM patients compared to healthy controls. Serum C peptide levels showed positive correlation with insulin and microalbminuria with the Pearson correlation analysis. However, there was no significant association between other variables and C peptide levels. Conclusion: A correlation was found between microalbuminuria and serum C-peptide in this present study. Findings suggest C-peptide is related with renal complications of T2DM patients.Öğe Association between Vitamin D Level and Microvascular Complications in Patients with Type 2 Diabetes(Kare Publ, 2017) Boyuk, Banu; Atalay, Hande; Değirmencioğlu, Şerife; Altay, Murat; Güzel, Savaş; Çelebi, Asian; Ayar, YavuzObjectives: The aim of this study was to further investigate the prevalence of Vitamin D deficiency in diabetes mellitus (DM) patients, as well as the association between hypovitaminosis D and the microvascular complications of type 2 (T2) DM. Methods: This was a cross-sectional, case-control study of 206 T2DM patients and 34 healthy control subjects. Participants were evaluated for the presence of diabetic retinopathy, nephropathy, and neuropathy. Results: The level of serum 25-hydroxyvitamin D (25(OH) D) was significantly lower in the T2DM patients (11.16 +/- 3.99 ng/mL vs. 15.58 +/- 3.16 ng/mL; p<0.05). Furthermore, 2.7% of the patients were found to have retinopathy (n=53), 3.6% had neuropathy (n=65), and 29.1% of the patients had microalbuminuria (n=60). Although serum 25(OH) D levels were significantly lower in the presence of retinopathy and neuropathy (p<0.05 for both), no significant association between Vitamin D level and microalbuminuria was found. Conclusion: An inverse relationship between the circulating 25(OH) D level and the prevalence of retinopathy and neuropathy in T2DM patients was determined. However, there was no significant association between microalbuminuria and the 25(OH) D level.Öğe Effect of the Atherogenic Index of Plasma on Microvascular Complications Associated with Type 2 Diabetes Mellitus(Istanbul Training & Research Hospital, 2015) Atalay, Hande; Boyuk, Banu; Değirmencioğlu, Şerife; Güzel, Savaş; Çelebi, Aslan; Ekizoğlu, İsmailObjective: The aim of this study was to evaluate the effects of the atherogenic index of plasma (AIP) on the microvascular complications of type 2 diabetes mellitus (DM) patients who applied to our internal medicine clinic. Methods: The study included 212 type 2 DM patients and 34 healthy controls who were compatible according to age and sex. Age, sex, duration of illness, treatment for diabetes and other illnesses associated with diabetes, height, weight, retinopathy, nephropathy, neuropathy, hypertension, and hyperlipidemia were recorded at the beginning of the study. AIP is calculated as the logarithm of the ratio between the triglyceride value and high density lipoprotein value (in mg/dL). Results: AIP and triglyceride levels of the type 2 DM patients were higher than those of the control group. Also, the study determined that 25.7% of the patients have retinopathy, 31.6% have neuropathy, 29.1% have microalbuminuria, and 3.9% have macroalbuminuria. If we accept that there is a complications who have one of these complications in this three, there is 62.6% of the patients have complications. A statistically significant correlation was determined with these complications and lipid subgroups such as AIP and low density lipoprotein (LDL). Conclusion: The relationship between AIP and only nephropathy, which is a complication in type 2 DM patients, was determined.Öğe No Relationship Between 25 Oh Vitamin D and Autoimmunity in Women Patients with Hypothyroidism(Carbone Editore, 2016) Boyuk, Banu; Altay, Murat; Atalay, Hande; Güzel, Savaş; Çelebi, Aslan; Ekizoğlu, İsmailIntroduction: Hypothyroidism is a common disease in the society. Based on the effects of vitamin D on immune system and endocrine system, the relationship between hypothyroidism and vitamin D gained importance. The relationship between vitamin D deficiency and thyroid was suggested for the first time by Kivity and his colleagues. In their study, they found a significant relationship between thyroid autoantibodies and vitamin D levels. In this study we want to show the relationship between autoimmunity and vitamin D deficiency in female patients with hypothyroidism. Materials and methods: This study was performed at the GOP Taksim Education and Research Hospital outpatient department of internal medicine between January and June in 2015. It included 80 females patients, and 18 control females subjects Results: A total of 98 participants were included in this study. The mean durations of hypothyroidism are 5,86 +/- 5,91 vs. 5,43 +/- 5,62 years. Anti-thyroid autoantibodies (Anti TPO) and anti-thyroglobulin antibodies (anti TG) levels were significantly higher in the group 1 patients compared to the group 2 patients and control subjects (p<0,01). There were no significant differences at other variables between the patients and control subjects. The serum 25-OH vitamin D levels were significantly lower in the Hashimoto thyroiditis and Non-Hashimoto thyroiditis patients compared to the healthy controls (10,88 +/- 9,19 ng/ml vs. 10,53 +/- 6,87 ng/ml, p<0.01). Conclusion: It was thought that the study's being conducted during the winter months might have affected vitamin D levels. The vitamin D value of the control group cases was found to be higher as compared to the case of hypothyroidism associated with Hashimoto's thyroiditis and of hypothyroidism associated with other reasons. No significant difference was observed in vitamin D levels between the groups of hypothyroidism associated with Hashimoto's thyroiditis and hypothyroidism associated with other reasonsÖğe Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus(Hindawi Ltd, 2014) Boyuk, Banu; Değirmencioğlu, Şerife; Atalay, Hande; Güzel, Savaş; Acar, Ayşe; Çelebi, Aslan; Şimşek, ÇağlarBackground and Aim. Studies have suggested that brain-derived neurotrophic factor (BDNF) plays a role in glucose and lipid metabolism and inflammation. The aim of this study was to evaluate the relationship between serum BDNF levels and various metabolic parameters and inflammatory markers in patients with type 2 diabetes mellitus (T2DM). Materials and Methods. The study included 88 T2DM patients and 33 healthy controls. Fasting blood samples were obtained from the patients and the control group. The serum levels of BDNF were measured with an ELISA kit. The current paper introduces a receiver-operating characteristic (ROC) generalization curve to identify cut-off for the BDNF values in type 2 diabetes patients. Results. The serum levels of BDNF were significantly higher in T2DM patients than in the healthy controls (206.81 +/- 107.32 pg/mL versus 130.84 +/- 59.81 pg/mL; P < 0.001). They showed a positive correlation with the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.28; P < 0.05), the triglyceride level (r = 0.265; P < 0.05), and white blood cell (WBC) count (r = 0.35; P < 0.001). In logistic regression analysis, age (P < 0.05), body mass index (BMI) (P < 0.05), C-reactive protein (CRP) (P < 0.05), and BDNF (P < 0.01) were independently associated with T2DM. In ROC curve analysis, BDNF cut-off was 137. Conclusion. The serum BDNF level was higher in patients with T2DM. The BDNF had a cut-off value of 137. The findings suggest that BDNF may contribute to glucose and lipid metabolism and inflammation.Öğe Relationship between plasma chemerin levels and disease severity in COPD patients(Wiley, 2015) Boyuk, Banu; Güzel, Eda Çelik; Atalay, Hande; Güzel, Savaş; Mutlu, Levent Cem; Küçükyalçın, VolkanBackground and AimsChronic inflammation of the lung is a characteristic finding in chronic obstructive pulmonary disease (COPD). The protein chemerin has been identified in inflammatory fluid and in inflamed tissues. This study aimed to determine the association between serum chemerin levels and the severity of COPD. MethodsForty-three COPD patients and 38 healthy subjects were enrolled in this study. Fasting plasma samples were obtained from the patient and the control group. Serum chemerin levels were measured using a commercial enzyme-linked immunosorbent assay. C-reactive protein levels, the erythrocyte sedimentation rate, and fibrinogen analysis were used to assess the inflammation status of the patients. Spirometric measurements with reversibility testing were performed in all the subjects. ResultsSerum chemerin levels were significantly elevated in the COPD patients (6.440.52 vs 5.22 +/- 0.59; P<0.001). A Mann-Whitney U-test revealed that the serum chemerin levels of stage 2 COPD patients were higher than those of stage 1 and 3 COPD patients (P=0.651). Cigarette smoking and plasma chemerin relation was also understudied; however, there was no significant relationship between current smokers and ex-smokers (P>0.05). Pearson's correlation analysis indicated that serum chemerin levels were positively correlated only with total cholesterol (T. cholesterol) (P<0.05, r=0.382). In the linear regression analysis, chemerin levels were associated with age (=0.321), triglycerides (=0.299) and T. cholesterol (=0.555). ConclusionOur study points to a relation between plasma chemerin levels and COPD. Larger patient groups are needed to verify the role of chemerin in the severity of COPD.Öğe Serum 25-hydroxyvitamin d levels and risk of incident heart failure in patients with newly diagnosed hypertension(Carbone Editore, 2015) Boyuk, Banu; Basmakci, Ayse; Yücel, Enver; Güzel, Savaş; Küçükyalçın, Volkan; Ekizoğlu, İsmailBackround and aims: Both vitamin D deficiency and hypertension widely effects general population. The studies about the interaction between these two condition is intriguing. This study aims to determine the association between levels of 25-hydroxyvitamin D (25[OH]D) in the sera of newly diagnosed hypertension patients and risk of incident heart failure. Methods: We recruited 50 newly diagnosed hypertension patients and 20 healthy controls and assessed them for left ventricular diastolic dysfunction by echocardiography. Patient blood was tested for 25(OH)D concentrations. Patient group is divided into two subgroups: Group 1 subjects <20 ng/ml 25 OH D and Group 2 subjects >= 20 ng/ml 25(OH). Results: We found that serum 25(OH)D (ng/ml) levels of patient group were significantly lower than the control group (15.63 +/- 5.71; p<0.004). E/A, and diastolic diameter were significantly different (p<0.05) between the Group 1 and Group 2. EF, diastolic diameter, systolic diameter, systolic arterial pressure, and gender had significant effects on the multivariate model (p<0.05). Conclusion: Study results support the theory that vitamin D deficiency plays a role in the development of heart failure. Our study found a relationship between 25(OH)D vitamin levels and left ventricular diastolic dysfunction in newly diagnosed hypertension patients.Öğe Serum Trace Elements in Type 2 Diabetes Mellitus(Carbone Editore, 2017) Atalay, Hande; Boyuk, Banu; Güzel, Savaş; Altay, Murat; Kızıler, Ali Rıza; Aydemir, BirsenStudies suggested that imbalances of several trace elements may play an important role in normal glucose and insulin metabolism. The aim of the present study was to evaluate changes in serum levels of copper, zinc, iron, and magnesium in patients with type 2 diabetes mellitus (T2DM) and their effect on glycemic control. Sixty female patients with T2DM and seventeen healthy subjects were enrolled in this study. Fasting plasma samples were obtained from the patient and control groups. Trace elements were studied using an atomic absorption spectrometer. Correlation analyses of trace elements with metabolic parameters were analyzed using Spearman's Rho correlation coefficient. T2DM patients had a significantly high fasting plasma glucose, glycated hemoglobin (HbA1C), and microalbuminuria levels (p< 0.05). Serum magnesium levels were significantly lower in patients with T2DM compared with the healthy controls (2.0 +/- 0.2 ng/mL vs. 2.3 +/- 0.2 ng/mL, p< 0.05). Serum copper levels showed a negative correlation with diabetes duration (r= -0.338, p= 0.011), and iron levels were negatively correlated with body mass index and C-reactive protein (r= -0.407, p= 0.009; r= -0.390, p= 0.017). Serum magnesium levels indicated a correlation with HbA1C and creatinine clearance (r= -0.371, p= 0.049; r= -0.462, p= 0.023), but no significant correlation was found with any of the other variables and zinc levels. The present study found low levels of magnesium, iron, copper, and zinc in women with T2DM, which supports a close relationship of the above trace elements with glucose metabolism. Low magnesium levels has been linked to poor glycemic control in T2DM; therefore, magnesium deficiency should be prevented in patients with diabetes.Öğe The Evaluation of Liver Steatosis with Transient Elastography in Metabolic Syndrome and the Relationship Between Serum Endorphin Levels(2021) Bilgin, Ebru Sinem; Beydoğan, Engin; Güzel, Savaş; Maviş, Osman; Boyuk, BanuObjective: Studies in recent times researching the correlation between serum endotrophinlevel and Type 2 DM have focused on the association of fatty liver with metabolic syndrome.This study aims to research the correlation between serum endotrophin levels, defined asa marker of metabolic dysregulation, with nonalcoholic fatty liver in metabolic syndromepatients, with increasing prevalence.Methods: Our prospective study included 40 patients (24 females and 16 males) with metabolicsyndrome attending the internal medicine clinic and 20 healthy volunteers (ten femalesand ten males). Evaluation of patients in terms of liver steatosis used transabdominal ultrasonographywith a Toshiba 500 Aplio brand model ultrasound device with 10 MHz convexprobe with transient elastography method. Fatty Liver Index and Hepatic Steatosis Index(HSI) were calculated on the basis sample analyses. The endotrophin levels were studiedwith a Sunred enzyme-linked ımmunosorbent assay kit.Results: Endotrophin levels were found to be lower in the group with metabolic syndromecompared to the healthy group and results were statistically significant different (p<0.001).When the mean elastography results for the groups (in m/s and kPa) are compared, therewere statistically significant differences found (p=0.001, p<0.001). There were statisticallysignificant differences between HSI score with serum insulin levels and homeostasis modelassessment results.Conclusion: In our study, a correlation was not found between endotrophin levels and fattyliver. Endotrophin is a parameter with newly discovered effects and is being researched forapplicability and reliability in clinical practice.
