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Öğe Association between C-peptide level and microalbuminuria in patients with type 2 diabetes mellitus(Cukurova Univ, Fac Medicine, 2018) Boyuk, Banu; Okuturlar, Yıldız; Uludag, Erdoğan; Atalay, Hande; Güzel, Savaş; Çelebi, AslanPurpose: Latest studies suggest that C-peptide may have a beneficial biological role on diabetic nephropathy. The aim of this study is to analyze whether there is an association between serum C-peptide level and microalbuminuria in type 2 diabetes mellitus (T2DM). Materials and Methods: We enrolled 184 T2DM patents and 46 healthy subjects in this study. Clinical variables and routine biochemical tests along with serum C peptide levels measured after an overnight fasting. Serum C peptide levels between 1.1 and 4.4 accepted as normal. 24-hour-urine samples were investigated and values between 30-300mgwere recorded as microalbuminuria. Pearson correlation analysis were used to determine associations between continuous variables. Results: C peptide levels were not significantly difference in T2DM patients compared to healthy controls. Serum C peptide levels showed positive correlation with insulin and microalbminuria with the Pearson correlation analysis. However, there was no significant association between other variables and C peptide levels. Conclusion: A correlation was found between microalbuminuria and serum C-peptide in this present study. Findings suggest C-peptide is related with renal complications of T2DM patients.Öğe Association between C-peptide level and microalbuminuria in patients with type 2 diabetes mellitus(2018) Böyük, Banu; Okuturlar, Yıldız; Uludağ, Erdoğan; Atalay, Hande; Güzel, Savaş; Çelebi, AslanPurpose: Latest studies suggest that C-peptide may have a beneficial biological role on diabetic nephropathy. The aim of this study is to analyze whether there is an association between serum C-peptide level and microalbuminuria in type 2 diabetes mellitus (T2DM). Materials and Methods: We enrolled 184 T2DM patents and 46 healthy subjects in this study. Clinical variables and routine biochemical tests along with serum C peptide levels measured after an overnight fasting. Serum C peptide levels between 1.1 and 4.4 accepted as normal. 24hour-urine samples were investigated and values between 30-300mgwere recorded as microalbuminuria. Pearson correlation analysis were used to determine associations between continuous variables. Results: C peptide levels were not significantly difference in T2DM patients compared to healthy controls. Serum C peptide levels showed positive correlation with insülin and microalbminuria with the Pearson correlation analysis. However, there was no significant association between other variables and C peptide levels. Conclusion: A correlation was found between microalbuminuria and serum C-peptide in this present study. Findings suggest C-peptide is related with renal complications of T2DM patients.Öğe Association between Vitamin D Level and Microvascular Complications in Patients with Type 2 Diabetes(Kare Publ, 2017) Boyuk, Banu; Atalay, Hande; Değirmencioğlu, Şerife; Altay, Murat; Güzel, Savaş; Çelebi, Asian; Ayar, YavuzObjectives: The aim of this study was to further investigate the prevalence of Vitamin D deficiency in diabetes mellitus (DM) patients, as well as the association between hypovitaminosis D and the microvascular complications of type 2 (T2) DM. Methods: This was a cross-sectional, case-control study of 206 T2DM patients and 34 healthy control subjects. Participants were evaluated for the presence of diabetic retinopathy, nephropathy, and neuropathy. Results: The level of serum 25-hydroxyvitamin D (25(OH) D) was significantly lower in the T2DM patients (11.16 +/- 3.99 ng/mL vs. 15.58 +/- 3.16 ng/mL; p<0.05). Furthermore, 2.7% of the patients were found to have retinopathy (n=53), 3.6% had neuropathy (n=65), and 29.1% of the patients had microalbuminuria (n=60). Although serum 25(OH) D levels were significantly lower in the presence of retinopathy and neuropathy (p<0.05 for both), no significant association between Vitamin D level and microalbuminuria was found. Conclusion: An inverse relationship between the circulating 25(OH) D level and the prevalence of retinopathy and neuropathy in T2DM patients was determined. However, there was no significant association between microalbuminuria and the 25(OH) D level.Öğe Effect of the Atherogenic Index of Plasma on Microvascular Complications Associated with Type 2 Diabetes Mellitus(Istanbul Training & Research Hospital, 2015) Atalay, Hande; Boyuk, Banu; Değirmencioğlu, Şerife; Güzel, Savaş; Çelebi, Aslan; Ekizoğlu, İsmailObjective: The aim of this study was to evaluate the effects of the atherogenic index of plasma (AIP) on the microvascular complications of type 2 diabetes mellitus (DM) patients who applied to our internal medicine clinic. Methods: The study included 212 type 2 DM patients and 34 healthy controls who were compatible according to age and sex. Age, sex, duration of illness, treatment for diabetes and other illnesses associated with diabetes, height, weight, retinopathy, nephropathy, neuropathy, hypertension, and hyperlipidemia were recorded at the beginning of the study. AIP is calculated as the logarithm of the ratio between the triglyceride value and high density lipoprotein value (in mg/dL). Results: AIP and triglyceride levels of the type 2 DM patients were higher than those of the control group. Also, the study determined that 25.7% of the patients have retinopathy, 31.6% have neuropathy, 29.1% have microalbuminuria, and 3.9% have macroalbuminuria. If we accept that there is a complications who have one of these complications in this three, there is 62.6% of the patients have complications. A statistically significant correlation was determined with these complications and lipid subgroups such as AIP and low density lipoprotein (LDL). Conclusion: The relationship between AIP and only nephropathy, which is a complication in type 2 DM patients, was determined.Öğe No Relationship Between 25 Oh Vitamin D and Autoimmunity in Women Patients with Hypothyroidism(Carbone Editore, 2016) Boyuk, Banu; Altay, Murat; Atalay, Hande; Güzel, Savaş; Çelebi, Aslan; Ekizoğlu, İsmailIntroduction: Hypothyroidism is a common disease in the society. Based on the effects of vitamin D on immune system and endocrine system, the relationship between hypothyroidism and vitamin D gained importance. The relationship between vitamin D deficiency and thyroid was suggested for the first time by Kivity and his colleagues. In their study, they found a significant relationship between thyroid autoantibodies and vitamin D levels. In this study we want to show the relationship between autoimmunity and vitamin D deficiency in female patients with hypothyroidism. Materials and methods: This study was performed at the GOP Taksim Education and Research Hospital outpatient department of internal medicine between January and June in 2015. It included 80 females patients, and 18 control females subjects Results: A total of 98 participants were included in this study. The mean durations of hypothyroidism are 5,86 +/- 5,91 vs. 5,43 +/- 5,62 years. Anti-thyroid autoantibodies (Anti TPO) and anti-thyroglobulin antibodies (anti TG) levels were significantly higher in the group 1 patients compared to the group 2 patients and control subjects (p<0,01). There were no significant differences at other variables between the patients and control subjects. The serum 25-OH vitamin D levels were significantly lower in the Hashimoto thyroiditis and Non-Hashimoto thyroiditis patients compared to the healthy controls (10,88 +/- 9,19 ng/ml vs. 10,53 +/- 6,87 ng/ml, p<0.01). Conclusion: It was thought that the study's being conducted during the winter months might have affected vitamin D levels. The vitamin D value of the control group cases was found to be higher as compared to the case of hypothyroidism associated with Hashimoto's thyroiditis and of hypothyroidism associated with other reasons. No significant difference was observed in vitamin D levels between the groups of hypothyroidism associated with Hashimoto's thyroiditis and hypothyroidism associated with other reasonsÖğe Red Cell Distribution Width and Acute Complications of Diabetes(Editura Acad Romane, 2018) Atalay, Hande; Boyuk, B.; Ateş, Murat; Güzel, Savaş; Çelebi, A.; Ekizoğlu, İsmailContext. Red cell distribution width (RDW) has been associated with type 2 diabetes (T2DM), however data in relation to diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar non-ketotic acidosis (HONK) remains unclear. Objective. The aim of this study was to evaluate the association between RDW, MCV, and RDW/MVC values and acute complications in T2DM. Patients and Methods. RDW was measured in 90 T2DM patients (30 DKA, 30 HONK and 30 T2DM without acute complications). Clinical variables were analyzed by One -Way ANOVA, Kruskal-Wallis and Pearson analysis with SPSS software. Diagnostic screening tests and ROC curve analysis determined the cut-off point of MCV,RDW and RDW/MCV values. Results. DKA patients had higher levels of plasma glucose (524.20 +/- 201.43mg/dL, p<0.001), HbA1c (10.73 +/- 2.29%, p<0.001), osmotic pressure (310.32 mosm/L, p<0.001), RDW (14.61 +/- 1.75g/L, p<0.01), and the RDW/MCV ratio (0.17 +/- 0.04%, p<0.01), compared to HONK patients. RDW/MCV cut-off value was 0.15 with 90% sensitivity 50% specifity these values for only MCV were 76.67%-70%, for only RDW were 76.67%-63.33% respectively. The area under curve values for the ability to reflect DKA for RDW and the RDW/MCV ratio were 0.708 and 0.766, respectively (p<0.001). Conclusions. RDW and RDW/MCV ratio were found associated with DKA and valuable in predicting DKA. However these parameters were not valuable in predicting HONK.Öğe Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus(Hindawi Ltd, 2014) Boyuk, Banu; Değirmencioğlu, Şerife; Atalay, Hande; Güzel, Savaş; Acar, Ayşe; Çelebi, Aslan; Şimşek, ÇağlarBackground and Aim. Studies have suggested that brain-derived neurotrophic factor (BDNF) plays a role in glucose and lipid metabolism and inflammation. The aim of this study was to evaluate the relationship between serum BDNF levels and various metabolic parameters and inflammatory markers in patients with type 2 diabetes mellitus (T2DM). Materials and Methods. The study included 88 T2DM patients and 33 healthy controls. Fasting blood samples were obtained from the patients and the control group. The serum levels of BDNF were measured with an ELISA kit. The current paper introduces a receiver-operating characteristic (ROC) generalization curve to identify cut-off for the BDNF values in type 2 diabetes patients. Results. The serum levels of BDNF were significantly higher in T2DM patients than in the healthy controls (206.81 +/- 107.32 pg/mL versus 130.84 +/- 59.81 pg/mL; P < 0.001). They showed a positive correlation with the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.28; P < 0.05), the triglyceride level (r = 0.265; P < 0.05), and white blood cell (WBC) count (r = 0.35; P < 0.001). In logistic regression analysis, age (P < 0.05), body mass index (BMI) (P < 0.05), C-reactive protein (CRP) (P < 0.05), and BDNF (P < 0.01) were independently associated with T2DM. In ROC curve analysis, BDNF cut-off was 137. Conclusion. The serum BDNF level was higher in patients with T2DM. The BDNF had a cut-off value of 137. The findings suggest that BDNF may contribute to glucose and lipid metabolism and inflammation.Öğe Relationship between plasma chemerin levels and disease severity in COPD patients(Wiley, 2015) Boyuk, Banu; Güzel, Eda Çelik; Atalay, Hande; Güzel, Savaş; Mutlu, Levent Cem; Küçükyalçın, VolkanBackground and AimsChronic inflammation of the lung is a characteristic finding in chronic obstructive pulmonary disease (COPD). The protein chemerin has been identified in inflammatory fluid and in inflamed tissues. This study aimed to determine the association between serum chemerin levels and the severity of COPD. MethodsForty-three COPD patients and 38 healthy subjects were enrolled in this study. Fasting plasma samples were obtained from the patient and the control group. Serum chemerin levels were measured using a commercial enzyme-linked immunosorbent assay. C-reactive protein levels, the erythrocyte sedimentation rate, and fibrinogen analysis were used to assess the inflammation status of the patients. Spirometric measurements with reversibility testing were performed in all the subjects. ResultsSerum chemerin levels were significantly elevated in the COPD patients (6.440.52 vs 5.22 +/- 0.59; P<0.001). A Mann-Whitney U-test revealed that the serum chemerin levels of stage 2 COPD patients were higher than those of stage 1 and 3 COPD patients (P=0.651). Cigarette smoking and plasma chemerin relation was also understudied; however, there was no significant relationship between current smokers and ex-smokers (P>0.05). Pearson's correlation analysis indicated that serum chemerin levels were positively correlated only with total cholesterol (T. cholesterol) (P<0.05, r=0.382). In the linear regression analysis, chemerin levels were associated with age (=0.321), triglycerides (=0.299) and T. cholesterol (=0.555). ConclusionOur study points to a relation between plasma chemerin levels and COPD. Larger patient groups are needed to verify the role of chemerin in the severity of COPD.Öğe Serum Trace Elements in Type 2 Diabetes Mellitus(Carbone Editore, 2017) Atalay, Hande; Boyuk, Banu; Güzel, Savaş; Altay, Murat; Kızıler, Ali Rıza; Aydemir, BirsenStudies suggested that imbalances of several trace elements may play an important role in normal glucose and insulin metabolism. The aim of the present study was to evaluate changes in serum levels of copper, zinc, iron, and magnesium in patients with type 2 diabetes mellitus (T2DM) and their effect on glycemic control. Sixty female patients with T2DM and seventeen healthy subjects were enrolled in this study. Fasting plasma samples were obtained from the patient and control groups. Trace elements were studied using an atomic absorption spectrometer. Correlation analyses of trace elements with metabolic parameters were analyzed using Spearman's Rho correlation coefficient. T2DM patients had a significantly high fasting plasma glucose, glycated hemoglobin (HbA1C), and microalbuminuria levels (p< 0.05). Serum magnesium levels were significantly lower in patients with T2DM compared with the healthy controls (2.0 +/- 0.2 ng/mL vs. 2.3 +/- 0.2 ng/mL, p< 0.05). Serum copper levels showed a negative correlation with diabetes duration (r= -0.338, p= 0.011), and iron levels were negatively correlated with body mass index and C-reactive protein (r= -0.407, p= 0.009; r= -0.390, p= 0.017). Serum magnesium levels indicated a correlation with HbA1C and creatinine clearance (r= -0.371, p= 0.049; r= -0.462, p= 0.023), but no significant correlation was found with any of the other variables and zinc levels. The present study found low levels of magnesium, iron, copper, and zinc in women with T2DM, which supports a close relationship of the above trace elements with glucose metabolism. Low magnesium levels has been linked to poor glycemic control in T2DM; therefore, magnesium deficiency should be prevented in patients with diabetes.Öğe Tip 2 Diyabet Mellituslularda Plazma Aterojenik Indexin Mikrovasküler Komplikasyonlara Olan Etkisi(2015) Atalay, Hande; Böyük, Banu; Değirmencioğlu, Şerife; Güzel, Savaş; Çelebi, Aslan; Ekizoğlu, İsmailAmaç: İç hastalıkları polikliniğimize başvuran tip 2 diyabet mellituslu hastalarda plazma aterojenik indeksin (AİP) mikrovasküler komplikasyonlar olan etkisini değerlendirmeyi amaçlanmıştır. Yöntemler: Çalışmaya 212 Tip 2 Diyabet Mellitus (DM) tanılı hasta ile yaş ve cinsiyet uyumlu 34 sağlıklı kişi olmak üzere toplam 246 kişi katıldı. Çalışma başlangıcında hastaların yaş, cinsiyet, hastalık yaşı, diyabete ve eşlik eden hastalıklara yönelik aldığı tedavi, boy-kilo, retinopati, nefropati, nöropati, hipertansiyon, hiperlipidemi varlığı kaydedildi. Plazma aterojenik indeksi desilitrede miligram olarak ölçülen plazma trigliserid düzeyinin yüksek dansiteli lipoprotein (HDL) düzeyine oranının 10 tabanındaki logaritması olarak hesaplandı. Bulgular: Çalışmamızda tip 2 DM hastalarda kontrol grubuna göre trigliserid ve plazma aterojenik indeksin daha yüksek olduğu görüldü. Ayrıca Tip 2 DM olgularında %25,7'sinde retinopati, %31,6'sında nöropati, %29,1'inde mikroalbüminüri, %3,9 makroalbüminüri olduğu saptanmıştır. Bu üç komplikasyondan herhangi birini gösterenlere komplikasyon var dersek olguların %62,6'sında komplikasyon olduğu görülmüştür. Çalışmamızda mikrovasküler komplikasyonlarla lipid alt grupları arasındaki ilişkiye baktığımızda mikroalbüminüri ile AİP ve düşük dansiteli lipoprotein (LDL) arasında istatistiksel anlamlı korelasyon saptanmıştır. Sonuç: Tip 2 diyabet hastaların mikrovasküler komplikasyonlarından sadece nefropati ile plazma aterojenik indeks arasında ilişki saptanmıştır.
