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Öğe Analysis of correlations between acetylcholinesterase, haptoglobin, tumor necrosis factor, serum amyloid A, and paraoxonase in Saanen goats with pregnancy toxemia(Polskie Towarzystwo Nauk Weterynaryjnych, 2024) Aytekin, İsmail; Güngör, Birol; Arslan, SezaiThe present study investigated the levels of acetylcholinesterase, tumor necrosis factor-? (TNF), paraoxonase (PON1), haptoglobin (HPT), serum amyloid A (SAA), beta-hydroxybutyric acid (BHBA), non-esterified fatty acid (NEFA), glucose, total protein, cholesterol, and triglyceride in Saanen goats with pregnancy toxemia. The animal material included Saanen goats aged 2-5 years. The study was conducted on a total of 20 Saanen goats: 10 pregnant and 10 healthy animals. After clinical examination, 10 goats with BHBA levels of more than 1.5 mmol/L of blood were included in the pregnancy toxemia group, and 10 healthy goats with BHBA levels of less than 1 mmol/L were included in the control group. There were no significant differences between the total protein, cholesterol, and triglyceride levels in the two groups. It was determined that, while the glucose level was low in the goats with pregnancy toxemia, BHBA, NEFA, acetylcholinesterase, tumor necrosis factor-?, paraoxonase, serum amyloid A, and haptoglobin levels were higher than they were in the healthy goats. In conclusion, it appears that ACHE, TNFa, PON, SAA, and HPT may be useful as additional indicators in the diagnosis of pregnancy toxemia and in the development of methods for its prevention. © 2024 Polskie Towarzystwo Nauk Weterynaryjnych. All rights reserved.Öğe Bacteriological, Virological and Parasitological Etiology in Diarrhea Cases in Determined in Post-mortem Lambs and Kids in Marmara Region(Van Yüzüncü Yıl Üniversitesi, 2016) Arslan, Sezai; Öncel, Taraneh; Malal, Mehmet Engin; Satır, Esra; Sait, Ahmet; Baca, Aysel Ünsal; Aydoğan, Demet YamanThe aim of this study was to determine bacterial, parasitological and viral agents of diarrhea in lamb and goat kid in Marmara Region of Turkey. The material of this study was consisted of 88 lambs and 26 kids which were younger than 6 months old. A total of 26 Escherchia coli (22.8%), 27 Eimeria spp. (23.7%), 11 Cryptosporidium spp. (9.6%) and 6 Clostridium perfringens (5.3%) were identified from samples. In addition Rotavirus and Pestivirus were detected in 3, 4 of 114 of samples respectively. It was concluded that determining the most common agents that cause diarrhea in young small ruminants in Marmara Region may contribute to therapeutic approaches and prophylactic medicine procedures.Öğe Determination of knowledge levels and attitudes of clinician veterinarians working in Thrace region towards antibiotic use(Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, 2024) Arslan, Sezai; Ural, Mehmet Nihat; Özdemir, NurullahAntimicrobial resistance (AMR) has become a global problem due to wide-spread antimicrobial use in human and veterinary medicine. AMR affects health systems by leading to prolonged and severe illnesses, high mortality rates, and treatment failures caused by resistant microorganisms. As antibiotics are the most widely used drugs in veterinary medicine, veterinarians’ knowledge, attitudes and practices regarding antibiotic use are crucial in combating AMR. In this cross-sectional study, an online questionnaire of 20 ques-tions was administered to clinician veterinarians and members of the Trakya Chamber of Veterinarians and 60 participants answered the questionnaire. In the current survey, 98 % of veterinarians agree that AMR is an important public health problem and emphasize that focusing on rational antibiotic use in veterinary medicine is a critical area to slow the development of AMR. Only 10 % of the respondents stated that they take into account antibiotic requests from patient owners, 68.3 % stated that they rarely use off-label drugs and 16.7 % stated that they often use them. Of those respondents, 16.7 % stated that they routinely perform antibiograms. Regarding education, 41.7 % of veterinarians had received training on rational antibiotic use. When asked about their preferred type of training, 56.7 % favored online training, while 35 % preferred face-to-face sessions. The results indicate that veterinarians play a significant role in combating AMR and that more awareness and education are needed in this field. © 2024 Sezai Arslan et al.Öğe Diagnosis and treatment of umbilical cord-derived tetanus in neonatal calves(Scientific Technical Research Council Turkey-Tubitak, 2017) Altuğ, Nuri; Yüksek, Nazmi; Karasu, Abdullah; İlhan, Fatma; Ceylan, Ebubekir; Ekin, İsmail Hakki; Arslan, SezaiIn this study, umbilical cord-derived neonatal tetanus in calves was identified in Turkey. Four calves with tetanus-specific history and clinical findings were used. Blood samples were taken before and after treatment, and clinical findings were recorded. A tetanus-specific treatment procedure was performed. However, the calves died from not responding to treatment. Pretreatment white blood cell, peripheral blood polymorphonuclear leukocyte, creatine kinase (CK), and lactate dehydrogenase (LDH) levels were determined to be high. Aspartate aminotransferase, alanine aminotransferase, CK, and LDH activities were found to increase after treatment compared to before treatment. Gram-positive terminal spore-forming bacilli were observed in bacterioscopic examination of the necrotic tissue and swab samples from the umbilical cord region. The umbilical cord region was determined to be infected in all calves. In histopathological examination, pyogranuloma formation was observed in the wound area, and in Gram staining agents morphologically concordant with Clostridium tetani in necrotic material were observed. Blood serum of the calves was inoculated into mice. All mice died within 2 days after the inoculation, showing tetanus-specific clinical findings. As a result, bacterioscopy and histopathology of the umbilical cord region may be useful for diagnosis in addition to clinical findings. Mice trials may be used in confirming the diagnosis.Öğe Diagnostic and prognostic value of procalcitonin (PCT), C reactive protein (CRP), nitric oxide (NO) levels, and adenosine deaminase (ADA) activity in sheep with natural babesiosis before and after treatment(Scientific Technical Research Council Turkey-Tubitak, 2018) Arslan, Sezai; Altuğ, Nuri; Muz, Mustafa Necati; Yüksek, Nazmi; Başbuğan, Yıldıray; Oruk Kılıç, ÖzlemThis study was carried out to reveal the importance of procalcitonin, C reactive protein, nitric oxide levels, and adenosine deaminase activity in the diagnosis and prognosis of the disease in naturally infected sheep with Babesia ovis. Thirty sheep diagnosed clinically and parasitologically as having Babesia ovis were allocated to 2 groups. The first group was treated only with imidocarp dipropionate and the second group with imidocarp dipropionate and flunixine meglumin. On the seventh day after treatment, blood samples were collected again from the sheep in the babesiosis-infected group and the treatment responses were assessed. Serum PCT (1.72 +/- 0.34 ng/mL, P < 0.01), CRP (101.42 +/- 11.73 mu g/mL, P < 0.001), NO (15.77 +/- 2.75 mu mol/L, P < 0.01), and ADA (13.92 +/- 0.88 IU/L, P < 0.01) were higher in sheep with babesiosis than in the healthy sheep (0.49 +/- 0.04 ng/mL, 49.46 +/- 4.57 mu g/mL, 8.15 +/- 0.63 mu mol/L, 9.34 +/- 1.19 IU/L, respectively). When PCT, CRP, NO, and ADA before treatment and after treatment in the infected sheep were compared, the levels of these parameters except for ADA in the second group were determined to have statistically decreased after the treatment. As a result, it has been concluded that the measurements of PCT, CRP, NO, and ADA in sheep with babesiosis may be useful for the diagnosis and prognosis of the disease when assessed in association with clinical examination.Öğe Effect of experimentally induced acute fluoride poisoning on the thyroid gland and hormones in geriatric rats(Polskie Towarzystwo Nauk Weterynaryjnych, 2024) Arslan, Sezai; Inan, SevdaThe aim of this study was to investigate the effects of fluoride on the thyroid gland and hormones in rats with acute poisoning by different doses of fluoride. For this purpose, a total of 5 groups were formed, including a control (C) group of 8 rats and 4 test groups consisting of 10 rats each. Toxicity was induced with NaF at doses of 45, 60, 70, and 90 mg/kg/bw in the test groups F45, F60, F70, and F90, respectively. During the study, 2 rats died in F45, 3 in both F60 and F70, and 4 in F90. Surviving rats were euthanized 24 hours after poisoning, and blood samples were collected. Urine samples were also taken before and after poisoning. Urinary fluoride levels increased after intoxication and were found to be statistically significant. There were no significant differences in the levels of thyroid hormones TT3, TT4, and FT4 between the test groups and the control group. However, a significant decrease in FT3 levels was observed in the test groups compared to the control group. Although there were no significant changes in TSH hormone levels in the F45 and F90 groups compared to the control group, a significant decrease was observed in the F60 and F70 groups. Histopathological examination revealed follicular degeneration, a decrease in the volume of colloidal fluid, and atypical follicular epithelium in the thyroid glands of the test groups. In conclusion, abnormal changes in the thyroid gland and hormones were observed in rats with acute poisoning by different doses of fluoride. © 2024 Polskie Towarzystwo Nauk Weterynaryjnych. All rights reserved.Öğe Effects of asprosin levels and selected biochemical parameters on conception in repeat breeder cows(Polish Soc Veterinary Sciences Editorial Office, 2024) Yenilmez, Kudret; Arslan, Sezai; Dogan, Hasan; Vicil, SinanThe purpose of this study was to investigate the effects of asprosin levels and various biochemical parameters (NEFA, BHBA, glucose, albumin, globulin, total protein, ALT, AST, and total bilirubin) on conception in repeat breeder (RB) cows. The study included sixty RB cows that had been inseminated at least three times, but had not been pregnant and had no gynecological abnormalities, as assessed by ultrasonography. From the sixty cows, two groups were selected at random: pregnant (Group I, n = 10) and non -pregnant (Group II, n = 10) animals. After estrus detection, a 10 mL blood sample was collected from each animal's tail vein. All animals were inseminated 12 hours after the start of estrus. The blood samples were centrifuged at 3000 rpm for 15 minutes, and the serum was extracted and stored at -80 degrees C until analysis. On the 45 th day after insemination, ultrasonography was used to examine the pregnancy. Asprosin levels were measured using ELISA, and biochemical tests (NEFA, BHBA, glucose, albumin, globulin, total protein, ALT, AST, total bilirubin) were performed with an autoanalyzer. Non -pregnant RB cows had considerably lower levels of asprosin (p < 0.05) than pregnant RB cows. When other biochemical parameters (BHBA, NEFA, glucose, albumin, ALT, AST, total bilirubin, total protein and globulin) were compared, there was no significant difference between the groups (p > 0.05). Thus, significantly elevated levels of asprosin in pregnant RB cows suggested that asprosin could play a role in RB cow conception. In addition, there was a positive correlation between asprosin levels and AST, total protein, and globulin levels in pregnant RB cows.Öğe Evaluation of Hematological, Biochemical Parameters and CRP and PCT Levels in Dogs with Leishmania Infantum Detected by ELISA(2024) Arslan, Sezai; Vıcıl, Sinan; Oncel, TaranehAim: Leishmaniasis, a zoonotic disease caused by Leishmania spp., follows a symptomatic or asymptomatic course in dogs due to the influence of various factors. Although hematological and serum biochemical parameters have a limited role in the diagnosis of leishmaniasis, they can be used to evaluate the clinical condition of the animal, the severity of the lesions and the prognosis of the disease. Procalcitonin (PCT), as a disease biomarker, is released by monocytes, neutrophils, liver, spleen, kidneys and lungs during sepsis. Serum C-reactive protein (CRP) increases significantly and rapidly in pathological conditions. This study aimed to examine PCT and CRP levels in dogs with Leishmaniasis. Materials and Methods: The leishmaniasis group of the study consisted of 9 dogs that tested positive for the disease using the ELISA method, among 157 dogs showing leishmaniasis symptoms. The healthy group consisted of seven dogs living in the same area, which were determined to be healthy through clinical examination, had normal hemogram and routine biochemical parameters, and tested negative in the ELISA test. Results: : The results showed that RBC, Hgb, HCT, MCV and MCHC values differed significantly between groups. The positive group had higher total protein and globulin levels, while the negative group had lower albumin, A/G ratio, sodium, and chloride values, biochemical measurements revealed. These differences between the groups were statistically significant, however serum PCT and CRP results were not different between the groups. Conclusion: Further research is required before PCT and CRP can be used as a clinical biomarker in dogs with leishmaniasis.Öğe Evaluation of Some Biochemical Parameters In Saanen Goats Naturally Infected With Mycoplasma agalactiae(Kahramanmaras Sutcu Imam Univ Rektorlugu, 2024) Arslan, SezaiMycoplasma agalactiae in sheeps and goats causes significant economic losses worldwide. The disease can cause mastitis, arthritis, ophthalmitis and less commonly abortion. This study aimed to reveal what kind of changes the disease causes in routine biochemical parameters and PCT and CRP levels in naturally infected goats. The material of the study consisted of fifteen naturally infected with Mycoplasma agalactiae and nine healthy (control group) female goats in a private commercial enterprise. M. agalactiae was diagnosed by a growth inhibition test in milk and blood serum. Serum biochemical analysis was performed by autoanalyzer. In the statistical study conducted between the control and infected groups, a significant decrease was found in albumin levels and A/G ratio in the infected group, and a significant increase in globulin, chlorine and potassium levels. No significance could be determined in levels of ALT, AST, D.BIL, T.BIL, BUN, Creatinine, Urea, Glucose, Na, P, CRP and PCT. As a result, it was revealed that PCT is not an important biomarker in goats with Mycoplasma agalactiae.Öğe Investigation of some hormones and some biochemical parameters that may be effective in the etiology of Repeat Breeder cows(Sivar-Soc Italiana Veterinari Animali Reddito, 2024) Yenilmez, Kudret; Dogan, Halef; Arslan, Sezai; Gokce, ElifThe aim of this study was to determine the role of anti-mullerian hormone (AMH), progesterone, insulin, thyroid stimulating hormone (TSH), triiyodotironin(T3), tiroksin(T4), non-esterified fatty acids (NEFA), beta hydroxy butyrate (BHBA) and glucose concentrations in the etiology of Repeat Breeder (RB) cows. In the study, 60 RB Holstein cows, all housed on the same farm and receiving identical care, feeding, and reproductive management, were inseminated at least three times but did not achieve pregnancy and were confirmed to have no gynecological problems through ultrasonographic examination. Were categorized into three groups based on parity: Group I (1-2 lactation), Group II (3-4 lactation), and Group III (5-6 lactation). During estrus, 10 ml blood samples were collected from all the animals in the study. Blood samples collected on the day of estrus were used to assess serum levels of AMH, insulin, BHBA, NEFA, glucose, T3, T4, and TSH. Additional blood samples were taken on days 9 and 17 post-mating for serum progesterone (P4) analysis. The serum samples were separated and stored at -80 degrees C until analysis. T3, T4, TSH, AMH and insulin levels were measured using an ELISA device, and serum progesterone, NEFA, BHBA and glucose determination were measured using an autoanalyzer. When comparing the results of hormone measurements across lactation groups, it was observed that T3 levels were highest in Group II and lowest in Group III. As for AMH, T4, TSH, insulin, and progesterone hormones, no statistically significant differences were found among the groups. Group I exhibited significantly lower NEFA levels compared to the other two groups, while Group I also had significantly higher glucose levels than the other two groups. In Group II, a statistically significant negative correlation of 69.7% was observed between T4 and AMH. In conclusion, this study determined that T3 hormone, NEFA and glucose levels may play a role in the etiology of RB cows, while AMH and other parameters do not seem to be effective.Öğe Investigation of the Presence of Escherichia coli and Escherichia coli O157:H7 Serotype with Clinical and Hematological Findings in Calves with Diarrhea in Van and its Region(Dicle Üniversitesi, 2023) Arslan, Sezai; Ağaoğlu, Zahid TevfikThe aim of this study is to investigate the clinical and hematological findings and the presence of Escherichia coli (E.coli) and E.coli O157:H7 serotype in calves with diarrhea in Van and its region. In the present study a total of 74 calves aged between 1 and 30 days in different breeds were tested. Out of 74 calves, 54 were diarrheic and 20 were healthy. Escherichia coli (E. coli) O157:H7 serotype together with some hametological parameters (Red blood cell (RBC), White blood cell (WBC), Hemoglobin (Hb), Packed cell volüme (PCV)) were investigated in the faeces of these diarrheic and healthy calves. According to examination and evaluation protocol, out of 54 diarrheic calves, 20 had a mild dehydration, 20 had medium dehydration and 14 had severe dehydration. Haematolojic parameters in calves with mild dehydration were not significantly different compared to the values obtained from control animals. However, PCV and Hb values were found to be significantly different (pÖğe Leishmania infantum'lu Köpeklerde Bazı Minerallerin Serum Düzeyleri(2021) Arslan, Sezai; Yenilmez, Kudret; Öncel, TaranehBu çalışmanın amacı Leishmania infantum (L. infantum)’lu köpeklerin kan serumunda magnezyum (Mg), mangan (Mn), bakır (Cu), çinko (Zn), selenyum (Se) ve molibden (Mo) düzeylerini ortaya koymaktır. Çalışmanın materyalini 14 L. infantum’lu ve 10 sağlıklı köpek oluşturdu. Anti L. infantum antikorlarının tespiti ELISA testiyle yapıldı. Serum mineral düzeylerine İndüktif Eşleşmiş Plazma Optik Emisyon Spektrometre (ICP-OES) cihazıyla bakıldı. Sağlıklı köpeklere göre layşmanyozisli köpeklerde serum Zn, Se ve Mo düzeylerinde azalma Cu düzeylerinde ise artma tespit edilmesine rağmen sadece Zn seviyesinde istatistiksel bir önem tespit edildi (P<0.05). Sonuç olarak layşmanyozisli köpeklerde serum Zn düzeyinde bir azalma olduğu ortaya konuldu.Öğe Leishmania infantum’lu Köpeklerde Bazı Minerallerin SerumDüzeyleri(2021) Arslan, Sezai; Öncel, Taraneh; Yenilmez, KudretBu çalışmanın amacı Leishmania infantum (L. infantum)’lu köpeklerin kan serumunda magnezyum (Mg), mangan (Mn), bakır (Cu), çinko (Zn), selenyum (Se) ve molibden (Mo) düzeylerini ortayakoymaktır. Çalışmanın materyalini 14 L. infantum’lu ve 10 sağlıklı köpek oluşturdu. Anti L. infantum antikorlarının tespiti ELISA testiyle yapıldı. Serum mineral düzeylerine İndüktif Eşleşmiş Plazma Optik Emisyon Spektrometre (ICP-OES) cihazıyla bakıldı. Sağlıklı köpeklere göre layşmanyozisliköpeklerde serum Zn, Se ve Mo düzeylerinde azalma Cu düzeylerinde ise artma tespit edilmesinerağmen sadece Zn seviyesinde istatistiksel bir önem tespit edildi (P<0.05). Sonuç olaraklayşmanyozisli köpeklerde serum Zn düzeyinde bir azalma olduğu ortaya konuldu.Öğe Morphological and molecular characterization of mucormycosis and other fungal agents in cattle(Veteriner Fakultesi Dergisi, 2024) Çiftci, Alper; Biyik, Hacı Halil; Arslan, Sezai; Özt?rk Köse, Senem; Gülhan, Timur; Boynukara, BanurMucormycosis is a type of opportunistic fungal infection caused by the Mucorales order of Zygomycetes. The study’s goal was to characterize Lichtheimia and other fungal agents in Tekirdağ province of Türkiye by morphological and molecular methods. Head hair and skin scrapings of 13 cattle with mucormycosis lesions inoculated onto Rose Bengal Agar, Potato Dextrose, and Malt Extract Agar. After the incubation at 25°C and 27°C, pure colonies were evaluated morphologically and microscopically. For molecular identification, DNA isolation and PCR studies were followed by sequence analysis and the results were compared with the data in GeneBank using the nBLAST tool. ITS1/ ITS4 primers used in PCR study. Fungal species were identified with data verified after morphological and molecular identification. The sequence analyses revealed that 12 samples had L. ramosa HBF570, 7 samples contained A. niger HBF572 and P. crustosum HBF571, 2 samples contained A. chevalieri HBF573 and A. flavus HBF576, and one sample contained A. pseudoglaucus HBF577 and Aspergillus sp. HBF570. The study’s causative agents emerged were environmental fungus species. In conclusion, because of the fungal diversity in the environment, hygiene investigations must be conducted and implemented for the protection of mucormycosis. © 2024, Veteriner Fakultesi Dergisi. All rights reserved.Öğe The effect of twinship on mineral matter, immunoglobulin G and lamb birth weight in late pregnant ewes and their newborn lambs(2021) Atalay, Hasan; Yenilmez, Kudret; Arslan, Sezai; Kılıç, ServetThe aim of this study was to investigate the effects of twinship on the mineral matter, immunoglobulin G (IgG), andlamb birth weight in late pregnant ewes and their lambs. The material of the study consisted of the 18 Kıvırcık breedewes, which were 130-150 days pregnant, and their 27 newborn lambs. The ewes included in the study weredivided into two groups by ultrasound as those carrying a single pregnancy (n=9) and a twin pregnancy (n=9). BodyCondition Scores (BCS) were determined and then their blood samples were taken. The lambs born from these eweswere weighed with precision scales as soon as they were born, and blood samples were taken 24 hours after birth.Mineral substance determination from blood samples was made by ICP-OES, and IgG determination was made byELISA. It was found that serum IgG and mineral matter levels were not affected by twinship in ewes (p>0.05).Calcium (Ca) level was significantly higher in twin lambs compared to single lambs (p<0.05). There was nostatistical difference between single and twin lambs in terms of other minerals and IgG concentrations (P>0.05).Total protein and globulin values were significantly higher in single lambs than twin lambs (P <0.05). It wasdetermined that single-born lambs were significantly heavier than twins (P<0.05), and while male lambs wereheavier than females, the difference between them was not statistically significant (P>0.05). As a result, it wasdetermined that twinship and BCS did not affect the mineral substance, total protein, albumin, globulin and IgGlevels in late pregnant ewes, while twinship in lambs affected lamb birth weight, total protein, globulin and Cavalues, but not other mineral and IgG levels. Significantly low total protein and globulin concentrations in twinlambs suggest that these animals cannot absorb enough colostrum.Öğe The effect of twinship on selected hematological and biochemical parameters in late pregnant ewes(Polskie Towarzystwo Nauk Weterynaryjnych, 2021) Yenilmez, Kudret; Arslan, Sezai; Kılıç, Servet; Atalay, HasanThis study aimed to determine the effect of twinship on the hematological and biochemical parameters in ewes of the Kıvırcık breed commonly raised in the Thrace region of Turkey. The study material consisted of 30 Kıvırcık ewes at days 130-150 of gestation, aged 3-5 years, weighing 55.61 ± 0.76 kg. After ultrasound examination, the ewes included in the study were divided into a single-pregnant group (n = 15) and a twin-pregnant group (n = 15), and their blood samples were taken. The levels of red blood cells (RBC), hematocrit (HCT), hemoglobin (HGB) white blood cells (WBC), lymphocytes (LYM), monocytes (MON), non-esterified fatty acid (NEFA), ?-hydroxybutyrate (BHBA), glucose, cholesterol, total protein, aspartate aminotransferase (AST), alanine aminotransferase (ALT) were determined in their blood samples. It was found that, although twinship did not affect hemogram values in ewes (p > 0.05), the biochemical parameters, BHBA, ALT, and AST values, were significantly affected by twinship (p < 0.05). A high positive correlation was found between BHBA and NEFA. Thus it was concluded that twin pregnancy did not cause any significant changes in hematological parameters in Kıvırcık ewes. However, the significantly higher BHBA in twin-pregnant ewes and the high positive correlation between BHBA and NEFA indicate that the negative energy balance started to affect these animals, and a carbohydrate deficiency emerged. Therefore, twin-pregnant ewes should be monitored closely to reduce the risk of ketosis. © 2021 Polskie Towarzystwo Nauk Weterynaryjnych. All rights reserved.Öğe The relationship between the levels of the fluoride ion and the thyroid hormones in goats with fluorosis(International Society for Fluoride Research, 2017) Arslan, Sezai; Keleş, İhsanIn the present study, 104 goats with endemic fluorosis, living at the foot of the mountains Ağrı (Mount Ararat) and Tendürek, were compared with 30 healthy goats to investigate the relationship between the plasma levels of the fluoride ion (F) and the thyroid hormones. In addition to the 104 goats with fluorosis all having dental fluorosis, 1.92% had exostoses in their palpable bones, 19.23% had mastication difficulties with weight loss, 2.88% had nail deformities, and 7.69% had lameness. However, signs of goitre in their necks were not present on inspection and palpation. The plasma F concentration was significantly higher (p<0.001) in the fluorosis group compared to the control group. The plasma F concentrations tended to be higher in the older animals compared to the younger animals, but not significantly so. Compared to the control group, the serum total thyroxine (TT4) was significantly reduced (p<0.01) in the fluorosis group. No significant differences between the fluorosis and the control groups were found for the serum concentrations of total triiodotyronine (TT3), free triiodotyronine (FT3), or free thyroxine (FT4). Significant decreases were present in the levels of TT3(p<0.01) and FT4(p<0.001) in the older goats with fluorosis, 3–5-years-old and >5-years-old, compared to the younger animals, aged 1–<3 years. © 2017, ISFR.Öğe The Relationship Between the Levels of the Fluoride Ion and the Thyroid Hormones in Goats with Fluorosis(Int Soc Fluoride Research, 2017) Arslan, Sezai; Keleş, İhsanIn the present study, 104 goats with endemic fluorosis, living at the foot of the mountains Agri (Mount Ararat) and Tendurek, were compared with 30 healthy goats to investigate the relationship between the plasma levels of the fluoride ion (F) and the thyroid hormones. In addition to the 104 goats with fluorosis all having dental fluorosis, 1.92% had exostoses in their palpable bones, 19.23% had mastication difficulties with weight loss, 2.88% had nail deformities, and 7.69% had lameness. However, signs of goitre in their necks were not present on inspection and palpation. The plasma F concentration was significantly higher (p < 0.001) in the fluorosis group compared to the control group. The plasma F concentrations tended to be higher in the older animals compared to the younger animals, but not significantly so. Compared to the control group, the serum total thyroxine (TT4) was significantly reduced (p < 0.01) in the fluorosis group. No significant differences between the fluorosis and the control groups were found for the serum concentrations of total triiodotyronine (TT3), free triiodotyronine (FT3), or free thyroxine (FT4). Significant decreases were present in the levels of TT3 (p < 0.01) and FT4 (p < 0.001) in the older goats with fluorosis, 3-5-years-old and > 5-years-old, compared to the younger animals, aged 1-< 3 years.Öğe Trakya bölgesindeki köpeklerde Leishmania infantum'un seropozitifliğinin ELISA yöntemiyle araştırılması(2019) Arslan, Sezai; Öncel, Taraneh; Yenilmez, Kudret; Turan, NesrinAmaç: Trakya bölgesindeki bazı geçici hayvan barınaklarında bulunan sahipsiz sokak köpeklerinde anti-Leishmania infantum (L. infantum) antikorlarının ELISA yöntemi ile araştırılması amaçlanmıştır.Gereç ve Yöntem: Çalışma materyalini Trakya bölgesinde bulunan Çanakkale/Gelibolu, Edirne/Uzunköprü, Kırklareli/ Merkez, İstanbul/Silivri ve Tekirdağ/Süleymanpaşa’danolmak üzere toplam 184 köpek oluşturmuştur. Köpeklerden alınan kan örneklerinden elde edilen serumlarda anti- L. infantum antikorlarının tespiti Enzyme-Linked Immuno-SorbentAssay (ELISA) yöntemi ile yapılmıştır.Bulgular: Anti- L. infantum antikorları yönünden incelenen 184 köpek serum örneğinin 16’sı seropozitif, (%8,7), 168 tanesi ise seronegatif (%91,3) olarak tespit edilmiştir. Çanakkale/Gelibolu ve Kırklareli merkezde pozitiflik saptanmazken, İstanbul/Silivri’de %13,9, Edirne/Uzunköprü’de %12,1 ve Tekirdağ/Süleymanpaşa’da %4 oranında pozitiflik saptanmıştır. Çalışmada seropozitiflik oranının cinsiyetle ilişkisinin olmadığı, 4 yaş ve üstü köpeklerde seropozitiflik oranının arttığı tespit edilmiştir.Öneri: Trakya bölgesinde Leishmaniasis’in insan ve köpek sağlığı için önemli bir zoonoz hastalık olduğu ve vektör Phelebotomus türlerinin araştırılmasının uygun olacağı görüşünevarılmıştır.
