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Öğe A new approach to the measurement of heart rate in patients with chronic heart failure-Heart rate performance index: an observational study(Aves, 2013) Akyüz, Aydın; Alpsoy, Şeref; Akkoyun, Dursun Çayan; Güler, NiyaziObjective: In order to evaluate the utility of the heart rate performance index (HRPI), which is obtained by dividing HR mean by the difference of HR max and HR min in the context of Holter monitoring, we sought to determine whether there was any correlation or relationship between the HRPI and LVEF values as determined by echocardiography and to compare the HRPI between the study and control groups. Methods: This study is a cross-sectional, controlled observational study. Thirty-two patients with symptomatic or asymptomatic left ventricular systolic dysfunction (LVEF <45%) were included as study group and 32 subjects without chronic heart failure (CHF) were included as a control group. In the study group, 10 patients were in NYHA class I (31.2%), 12 - were in NYHA class II (37.6%) and 10 - were in NYHA class III (31.2%). Heart rate analysis was measured using 24-hour Holter ambulatory electrocardiography. To determine the HRPI, the difference between maximum (HR max) and minimum heart rate (HR min) was divided by mean heart rate (HR mean) (beats/minute): HRPI=(HR max-HR min) / HR mean. Statistical analysis was performed using t-test for independent samples, Mann-Whitney U test, Chi-square test, Kruskal-Wallis test, Pearson's correlation and linear regression analyses. Results: The HRPI index value was markedly decreased [0.83 (0.58-1.1) and 1.10 (0.74-1.3), p<0.001] in the study group as compared to the control group. The data collected for the study group and the control group (n=64) demonstrated a positive correlation between the HRPI and LVEF (r=0.62, p<0.001) as well as a negative correlation between the HR mean and LVEF (r=-0.39, p<0.003). The HR mean was higher (80.2 +/- 11.3 and 75.2 +/- 6.7, p<0.007) and HR max-HR min (67.9 +/- 11.6 and 83.3 +/- 14.3, p<0.001) were lower in the study group as compared to the control group. Linear regression analysis demonstrated no significant relationship between LVEF and HRPI and other heart rate derivatives (unstandardized beta=42.43 95% CI: 21.98-50.51, p=0.231). Conclusion: According to our findings, patients with CHF exhibited higher HR mean values, reduced HR max-min values and significantly decreased HRPI values. There is a positive correlation between HRPI and LVEF, a decreased HRPI is associated with a decreased LVEF, but there is no relationship between these two variables. Therefore HRPI values may represent a viable option for assessing daily exercise activity and potentially sympathetic activation in patients with CHF. The assessment of HRPI may be helpful the evaluation of CHF patients, as well as resting HR.Öğe Akciğer Ve Sağ Kalp Tutulumu Olan Bir Kist Hidatik Olgusu(Namık Kemal Üniversitesi, Tıp Fakültesi, 2013) Akyüz, Aydın; Es, Mehmet Uğur; Alpsoy, Şeref; Akkoyun, Dursun ÇayanEchinococcus granulosus ile oluşan kist hidatik hastalığı endemiktir ve halen ciddi bir hastalıktır. Kardiyak ekinokokoz is çok nadir görülür. Bu yazıda kuru öksürük, egzersize bağlı nefes darlığı ve halsizlik şikâyeti ile birlikte gelen ve hem kalp hem de akciğer tutulumu olan bir olgumuzu bildirmeyi amaçladıkÖğe An imaging of paradox flow in coronary artery collateralization(2013) Akyüz, Aydın; Alpsoy, Şeref; Akkoyun, Dursun Çayan; Güler, Niyazi[No abstract available]Öğe Anomalous origin of left internal mammary artery from distal subclavian artery(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2014) Uygur, Ramazan; Akyüz, Aydın; Çağlar, Veli; Alpsoy, Şeref; Akkoyun, Dursun ÇayanThe internal mammary artery arises from the first part of the subclavian artery. The left internal mammary artery (LIMA) is an excellent graft for myocardial revascularization of the left anterior descending artery. In this article, we describe a quite important variation of an anomalous origin of LIMA, which is rarely seen. In our case, LIMA was arising from the distal of the third part of the subclavian artery. Therefore, it is of utmost importance to perform LIMA angiography before coronary artery bypass grafting surgery.Öğe Anomaly of the Conus Artery Arising from the Right Coronary Artery(Taiwan Soc Cardiology, 2013) Çağlar, Veli; Akyüz, Aydın; Uygur, Ramazan; Alpsoy, Şeref; Akkoyun, Dursun ÇayanSome anomalies of the conus artery are relatively common, such as those arising from the discrete ostium of the right coronary artery. We report a 63 y/o male with an unusual anatomic variation of the conus artery terminating in the pericardium. Coronary anomalies may cause coronary ischemia, infarction and sudden cardiac death; hence, it is significant to identify coronary anomalies. Here, we identify an unusual conus artery anomaly for the first time, with accompanying imaging showing its very rare anatomical features that may be of interest to the larger medical community.Öğe Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats(Wiley, 2013) Alpsoy, Şeref; Aktaş, Cevat; Uygur, Ramazan; Topçu, Birol; Kanter, Mehmet; Erboğa, Mustafa; Gedikbaşı, AsumanThe aim of this study was to investigate the antioxidant and anti-apoptotic effects of onion (Allium cepa) extracts (ACE) on doxorubicin (DOX)-induced cardiotoxicity. The rats in the ACE-pretreated group were given a daily dose of 1 ml ACE for 14 days. To induce cardiotoxicity, DOX (30 mg kg-1 body weight) was injected intraperitoneally by a single dose and the rats were sacrificed after 48 h. To date, no such studies have been performed on the cardioprotective and anti-apoptotic potential of ACE on DOX-induced cardiotoxicity. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling in cardiomyocytes of the DOX-treated group with ACE therapy. The DOX-treated with ACE groups showed a significant decrease in malondialdehyde levels, and increased activities of superoxide dismutase, glutathione and glutathione peroxidase in comparison with the DOX-treated group. Creatine kinase, creatine kinase MB, lactate dehydrogenase activities and cardiac troponin I levels were significantly decreased in the DOX + ACE group in comparison with the DOX group. These biochemical and histological disturbances were effectively attenuated on pretreatment with ACE. The present study showed that ACE may be a suitable cardioprotector against toxic effects of DOX. Copyright (C) 2011 John Wiley & Sons, Ltd.Öğe Aortic Pressures, Stiffness and Left Ventricular Function in Coronary Slow Flow Phenomenon(Karger, 2010) Tanrıverdi, Halil; Evrengül, Harun; Kılıç, I. Doğu; Taşköylü, Özgür; Doğan, Güllü; Alpsoy, ŞerefBackground: Coronary slow flow (CSF) phenomenon is characterized by delayed opacification of coronary vessels in a normal coronary angiogram. Although clinical and pathological features have been previously described, the underlying pathophysiology has not been fully elucidated. In this study, we aimed to evaluate central aortic pressure, aortic stiffness and left ventricular (LV) function in patients with coronary slow flow. Method and Results: The study population consisted of 154 patients who underwent coronary angiography because of typical and quasi-typical symptoms of angina. 81 patients with angiographically proven CSF and 73 cases with normal coronary flow pattern with similar risk profiles were enrolled in the study. Aortic pressures and indexes of elastic properties were evaluated using invasive methods. Aortic pulse pressure (mm Hg) and pulsality index of patients with CSF were found to be significantly higher than those of controls (60.8 +/- 13.8 vs. 53.7 +/- 14.5, p = 0.002; 0.84 +/- 0.22 vs. 0.67 +/- 0.18, p = 0.0001, respectively). LV Doppler parameters were deteriorated in patients with CSF. Aortic fractional pulse pressure and pulsality index were significantly correlated with the mean TIMI frame count and LV diastolic parameters in correlation analysis. Conclusion: The present findings allow us to conclude that impaired aortic elasticity in patients with CSF may also be responsible for the impaired LV diastolic parameters. Copyright (C) 2010 S. Karger AG, BaselÖğe Assessment of salusin alpha and salusin beta levels in patients with newly diagnosed dipper and non-dipper hypertension(Taylor & Francis Inc, 2021) Alpsoy, Şeref; Doğan, Burçin; Özkaramanlı Gür, Demet; Akyüz, Aydın; Fidan, Çiğdem; Güzel, Savaş; Özkoyuncu, BernaObjective The pathophysiology of non-dipper hypertension has not been clarified. The relationship between salusins with atherosclerosis and hypertension has gained attention in recent years. The aim of this paper is to investigate whether salusins are associated with circadian blood pressure, left ventricular mass index, and diastolic functions in newly diagnosed hypertensives. Methods The study included 88 newly diagnosed hypertensive individuals. Twenty-four-hour ambulatory blood pressure monitoring and echocardiographic examinations were performed. The patients were assigned to dipper hypertension (n = 41) and non-dipper hypertension (n = 47) groups based on the ambulatory blood pressure monitoring results according to the presence of >= a 10% decrease in nighttime blood pressure values or not. Serum salusin alpha and beta levels were determined by electrochemiluminescence immunological test method. Results Compared to dipper hypertension, non-dipper hypertension group demonstrated lower salusin alpha levels (1818.71 +/- 221.67 vs 1963 +/- 200.75 pg/mL,p= .002), mitral E/A, septal E'/A' and higher salusin beta levels (576.24 +/- 68.15 vs 516.13 +/- 90.7 pg/ml,p= .001) and left ventricular mass index. Multivariate logistic regression analysis revealed salusin-alpha (OR 0.474, 95% CI 0.262 to 0.986,p= .001), salusin-beta (OR 2.550, 95% CI 2.123 to 2.991,p= .018), and left ventricular mass index (OR 2.620, 95% CI 2.124 to 2.860,p= .011) as independent predictors of non-dipper hypertension. As candidate markers to predict non-dipper hypertension, decreased salusin alpha, and increased salusin beta levels may mediate crosstalk between sympathetic and parasympathetic systems and indicate poor cardiovascular prognosis in hypertension.Öğe Association between drug resistant hypertension and increased osteoprotegerin levels in hypertensive male patients with non obstructive sleep apnea(Carbone Editore, 2014) Akyüz, Aydın; Oran, Mustafa; Alpsoy, Şeref; Mutlu, Levent Cem; Değirmenci, Hasan; Küçükyalçın, Volkan; Alp, RecepObjectives: Increased carotid intima-media thickness (IMT) reflects subclinical vascular damage and is related to obstructive sleep apnea (OSA) syndrome and hypertension. Osteoprotegerin OPG is a member of the tumor necrosis factor superfamily and increases leukocyte adhesion. The relationship between increased OPG and atherosclerosis is Well known, but there is still no evidence whether there is an association between OPG and resistant hypertension. This study investigated the association between OPG and drug resistant hypertension in patients With OSA and non-OSA. Patients and methods: We investigated the association between serum OPG levels and carotid IMT in patients With drug resistant hypertensive OSA (ODR) patients (n= 39) and drug resistant hypertensive non-OSA(NODR) patients (n=34) and drug-responsive hypertensive non-OSA controls (n=36). Results: OPG levels and carotid IMT were found to be higher in the ODR [12.4(5.9-19.5) and 0.89 +/- 0.51 and in the NODR group [11.9(5.7-17.6) and 0.88 +/- 0.6] compared with the controls [8.4(4.8-16.5) pmollL and 0.73 +/- 0.8 um], (p= 0.01 and p=0.01 for OPG and p<0.01 and p<0.01 for carotid IMT). The carotid IMT was positively correlated with OPG levels in the ODR. group (r=0.412, p=0.016) and in the NODR group(r=0.321, p=0.024) and with apnea hypopnea index (r=0.462, p<0.001) in the ODR. There was no correlation between OPG and apnea-hypopnea index (r=0.07, p=0.564) in the ODR group. Conclusions: Increased serum OPG levels were associated with subclinical carotid atherosclerosis in patients with ODR and NODR, but not with drug-response non-OSA controls.Öğe Association Between Serum Fetuin-A levels, Carotid Artery Stiffness, and Intima-Media Thickness in Patients With Normotensive Obstructive Sleep Apnea Syndrome(Sage Publications Inc, 2014) Akyüz, Aydın; Oran, Mustafa; Alpsoy, Şeref; Mutlu, Levent Cem; Akkoyun, Dursun Çayan; Güzel, Savaş; Alp, RecepIncreased carotid intima-media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association between serum fetuin-A levels and carotid artery stiffness and cIMT in patients with normotensive OSAS (n = 50) and non-OSAS controls (n = 38). Compared with controls, there were lower fetuin-A levels (59.4 +/- 6.5 vs 68.2 +/- 5.8 ng/mL, P = .029), higher mean cIMT (0.73 +/- 0.2 vs 0.63 +/- 0.3 mm, P < .001), and greater stiffness (beta) index (7.45 +/- 0.9 vs 5.2 +/- 0.7, P = .001) in the OSAS group. The cIMT and stiffness (beta) index were inversely correlated with fetuin-A levels (r = -.324, P = .033; r = -.466, P < .001, respectively) and positively correlated with apnea hypopnea index (r = .498, P < .001; r = .422, P = .001, respectively) in the OSAS group. Decreased serum fetuin-A levels were associated with subclinical carotid atherosclerosis in patients with normotensive OSAS.Öğe Association of lower serum irisin levels with diabetes mellitus: Irrespective of coronary collateral circulation, and syntax score(Kare Publ, 2021) Akyüz, Aydın; Mert, Beysim; Özkaramanlı Gür, Demet; Efe, Muhammet Mucip; Aykaç, Hüseyin; Alpsoy, Şeref; Güzel, SavaşOBJECTIVE: Irisin is a myokine thought to be involved in the pathophysiological process of atherosclerosis with its' cardiovascular protective effects. Patients with diabetes mellitus (DM) have lower levels of irisin. Therefore, we investigated whether there is a connection between irisin, DM, coronary collateral circulation (CCC), and SYNTAX scores representing coronary artery disease (CAD) severity. METHODS: This study evaluated 86 patients who have at least one epicardial coronary artery with chronic total occlusion. We included Rentrop 0-1 into the poor CCC group (n=45) and Rentrop 2-3 into the good CCC group (n=41) and measured serum irisin levels. RESULTS: Irisin levels did not differ (17585 [882-37741] pg/ml and (17504 [813-47683] pg/ml, p=0.772) between the two groups. Irisin levels were lower in patients with diabetes (n=41; 14485 [813-29398] pg/ml) than those without diabetes (n=45; 19724 [865-47683] pg/ml (p=0.002). Irisin was not correlated with SYNTAX scores. In multivariate analysis, DM (OR=0.463; CI: 0.184-0.783; p=0.012) was a negative predictor of good CCC development CONCLUSION: Although its level is decreased in patients with diabetes, serum irisin levels have no role in the pathophysiology of collateral development and CAD severity.Öğe Atherosclerosis, some serum inflammatory markers in psoriasis(Edizioni Minerva Medica, 2014) Alpsoy, Şeref; Akyuz, A.; Erfan, Gamze; Akkoyun, Dursun Çayan; Topçu, Birol; Güzel, Savaş; Kulaç, MustafaAim. Psoriasis is an autoimmune inflammatory disease which is associated with increased inflammatory markers and atherosclerosis. We wanted to investigate whether there is a relationship between some inflammatory markers and subclinical atherosclerosis markers. Methods. We studied 60 psoriasis patients and 50 healthy controls. Demographic, biochemical parameters, C3, C4, d-dimer, CRP, fibrinogen and YKL-40 (human cartilage glyco-protein-39) levels were measured. After measuring carotid intima-media thickness (cIMT) and aortic elasticity parameters such as aortic strain, (beta) stiffness index and compliance, statistical comparisons were done. Results. Patients with psoriasis had significantly higher diastolic blood pressure, CRP, fibrinogen, C3, uric acid levels, beta-stiffness index, and cIMT values than the control group. cIMT was correlated with CRP, YKL-40 and psoriasis area and severity index (PASI) score (r=0.219, P=0.038; r=0.225, P=0.033 and r=0.275, P=0.034). Aortic strain (%), aortic compliance and aortic stiffness index were correlated with C3 (r=-0.349, r=-0.526 and r=0.235) and fibrinogen (r=-0.354, r=-0.275 and r=0.289), all P values <0.05, but not with PASI score. The presence of psoriasis was related to aortic strain (beta +/- SE: -2.055 +/- 0.861, P=0.019) and beta-stiffness index (beta +/- SE: 2.934 +/- 1.143, P=0.012). Conclusion. Serum C3, CRP, fibrinogen and YKL-40 levels are elevated as well as increased cIMT and impaired aortic elasticity in psoriasis. CRP, YKL-40 and PASI score are correlated with cIMT. Increased serum C3 and fibrinogen levels correlate negatively with aortic strain and aortic compliance, and correlate positively with the beta-stiffness index.Öğe Atriyal Fibrilasyon ile Başvuran Aort Koarktasyonu: Olgu Sunumu(Namık Kemal Üniversitesi, Tıp Fakültesi, 2013) Alpsoy, Şeref; Akyüz, Aydın; Akkoyun, Dursun Çayan; Gürkan, Selami; Değirmenci, HasanAort koarktasyonu dikkatli fizik muayene ile bebeklik ve çocukluk çağında kolay tanı konabilen doğumsal kalp hastalıklarından biridir. Erken tanı konulamayan ve erişkin yaşa ulaşan hastalar genellikle hipertansiyon ile başvururlar. Komplikasyonlar geliştiği zaman genellikle ölümle sonuçlandığı için aort koarktasyonu teşhis edilir edilmez uygun vakalarda stent implantasyonu veya cerrahi onarım hayati önem taşımaktadır. Atrial fibrilasyon, biküspit aort kapak, çıkan aorta anevrizması ve aort koarktasyonu olan bir hastayı sunduk.Öğe Author's reply(Turkish Society of Cardiology, 2016) Akkoyun, Dursun Çayan; Akyüz, Aydın; Kurt, Ömer; Bilir, Bülent; Alpsoy, Şeref; Güler, Niyazi[No abstract available]Öğe Author's Reply [2020](Turkish Society of Cardiology, 2020) Akyüz, Aydın; Aydın, Fatma; Alpsoy, Şeref; Özkaramanlı Gür, Demet; Güzel, Savaş[No abstract available]Öğe Can the development of atrial fibrillation in patients with ischemic heart failure with low ejection fraction be predicted?(Kare Publ, 2020) Alpsoy, Şeref; Erselcan, Kubilay; Akyüz, Aydın; Özkaramanlı Gür, Demet; Topuz, Sahin; Topçu, Birol; Güler, NiyaziOBJECTIVE: Our aim is to determine the triggering factors of paroxysmal atrial fibrillation (PAF) in ischemic heart failure (HF) patients with low ejection fraction (EF). METHODS: Sixty patients were included in this study. Echocardiography and 24-hours Holter monitoring were performed after measurement of serum NT-pro BNP concentration. The patients were classified into two groups concerning the occurrence of PAF on Holter recordings. Biochemical and echocardiographic parameters of patients with and without PAF were compared. RESULTS: PAF was detected in 28 (46%) patients. Patients with PAF demonstrated higher NT-pro BNP levels, mitral and aortic regurgitation velocities, E/A, E/E', pulmonary capillary wedge pressure, pulmonary artery systolic pressure, left atrial volume and volume indices. NT-pro BNP was established as the predictor of PAF (OR=1.23, 95% CI: 1.08-1.42; p=0.001).ROC analysis showed an NT-pro BNP value of 2188 pg/mL as cut-off value with 68% sensitivity and 84% specificity [Area under the ROC curve (AUC)=0.826, CI 95%: 0.724-0.927; p<0.001]. CONCLUSION: The triggering factors for AF are increased intracardiac pressures, left atrial dilatation and increased wall tension. As an indicator of increased wall tension, elevated levels of NT-pro BNP predict the development of PAF.Öğe Cardioprotective effects of fish omega-3 fatty acids on doxorubicin-induced cardiotoxicity in rats(Sage Publications Ltd, 2014) Uygur, Ramazan; Aktaş, Cevat; Tülübaş, Feti; Alpsoy, Şeref; Topçu, Birol; Özen, Oğuz AslanThe aim of this study was to investigate the protective effects of fish omega-3 (n-3) fatty acids on doxorubicin (DOX)-induced acute cardiotoxicity. A total of 24 rats were divided into three groups: control, DOX-treated, and DOX treated with fish n-3 fatty acids. Control group received 0.4 ml/kg/day of saline intragastrically. The rats in the fish n-3 fatty acid-pretreated group were given 400 mg/kg/day fish n-3 fatty acids for 30 days by intragastric intubation. To induce acute cardiotoxicity, DOX (30 mg/kg) was injected intraperitoneally by a single dose and the rats were killed after 48 h. DOX treatment caused severe damage in heart tissues. Disorganization of myocardial muscle fibers, myofibrillar loss, and cardiotoxic myocardial fibers with cytoplasmic vacuoles were seen. Fish n-3 fatty acid-treated rats showed an improved histological appearance in the DOX-treated group. Our data indicate a significant reduction in the activity of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling in cardiomyocytes of the DOX-treated group with fish n-3 fatty acids therapy. The DOX-treated with fish n-3 fatty acids group showed a significant decrease in malondialdehyde levels, and an increase in superoxide dismutase and glutathione peroxidase activities in comparison with the DOX-treated group. This study showed that fish n-3 fatty acids may be a suitable cardioprotector against acute toxic effects of DOX.Öğe Carotid intima-media thickness and serum paraoxonase-1 activity in patients with Helicobacter pylori(Verduci Publisher, 2013) Mete, Rafet; Oran, Mustafa; Alpsoy, Şeref; Güneş, H.; Tülübaş, Feti; Turan, C.; Yıldırım, OğuzhanAIM: To evaluate serum paraoxonase(PON)-1 activity and carotid intima-media thickness (CIMT) in patients with Cytotoxin-associated antigen(CagA)-positive and negative Helicobacter pylori strains. PATIENTS AND METHODS: The study group included a total of 134 individuals, of whom 103 were H. pylori positive, and 31 were H. pylori negative. Five biopsies were collected from each patient for histological examination: two from the antrum, two from the corpus, and one from the incisura angularis. The presence of H. pylori was determined using a modified Gram staining protocol. Peripheral blood was collected from each patient to determine levels of triglyceride, TC, HDL-cholesterol and LDL-cholesterol. IgG antibodies against CagA protein were analyzed by enzyme immunoassays. PON-1 activity was measured by colorimetric method. Carotid intima-media thickness and atherogenic plaques were measured using a grey scale color Doppler ultrasound. Data were analyzed by descriptive and inferential statistics. RESULTS: The right, the left and the mean CIMT were significantly higher in H. pylori (+) group versus H. pylori (-) group (p < 0.001 for all). However, the mean PON-1 concentration was significantly lower in H. pylori (+) group versus H. pylori (-) group (p < 0.001). The right, the left and the mean CIMT of CagA (+) group were significantly higher than that of CagA (-) group and controls, while PON-1 concentrations of CagA (+) group were significantly lower than that of CagA (-) group and controls (for all p = 0.0001). The right, the left and the mean CIMT of CagA (-) group were significantly higher than that of the control group, while the mean PON-1 concentration were significantly lower (for all p = 0.0001). CONCLUSIONS: Decreased PON-1 activity may be an etiopathogenetic factor in increased atherosclerosis in patients with H. pylori infection, especially in those infected with the CagA positive strain.Öğe Çocuklarda kilo fazlalığının kalp fonksiyonlarına etkisi(2013) Alpsoy, Şeref; Akyüz, Aydın; Akkoyun, Dursun Çayan; Nalbantoğlu, Burçin; Topçu, Birol; Değirmenci, Hasan; Donma, Mustafa MetinAmaç: Obezitenin kalp yetersizliği riski ile ilişkili olduğu bilinmektedir. Semptomsuz sol ventrikül (SV) diyastolik fonksiyon bozukluğu kalp yetersizliği gelişmesi ile ilişkilidir. Çocuklarda kilo fazlalığının subklinik SV diyastolik fonksiyon bozukluğu ile ilişkili olup olmadığı belli değildir. Bu çalışmanın amacı kilolu çocuklarda SV kitle indeksi ve SV diyastolik fonksiyonları üzerine beden kütle indeksi (BKİ) ve bel çevresinin etkisini değerlendirmektir. Çalışma planı: Çalışmaya normal kilolu (yaşa göre ayarlanmış BKİ: %15-85 arası) 91 ve fazla kilolu (yaşa göre ayarlanmış BKİ: %85-95 arası) 61 olmak üzere toplam 153 çocuk katıldı. İki boyutlu, M-Mode görüntüleme ile boyutlar ve çaplar ölçüldü. SV diyastolik fonksiyonu geleneksel ve doku Doppler görüntüleme ile değerlendirildi. Bulgular: Kilolu çocuklarda yüksek yoğunluklu kolesterol düşük, sistolik ve diyastolik kan basıncı (KB), serum insülini, HOMA indeksi, trigliserit (TG), sol atriyum, aort ve SV çapları, SV duvar kalınlıkları, sol ventrikül kitlesi (SVK) ve sol ventrikül kitle indeksi (SVKİ) fazla idi. Mitral anülüs septal e, septal e/a, lateral e, lateral e/a, triküspit lateral anülüs e ve e/a değerleri düşüktü. Mitral anülüs septal e, lateral e, triküspit lateral anülüs e, mitral anülüs septal e/a, lateral e/a ve triküspit lateral anülüs e/a ile BKİ, bel çevresi, serum insülin düzeyi, HOMA indeksi, sistolik ve diyastolik KB arasında negatif korelasyon bulundu. SVKİ ile BKİ ve bel çevresi arasında pozitif korelasyon bulundu. Mitral anülüs septal e, septal e/a, lateral e, lateral e/a için sadece BKİ öngördürücü olarak tespit edildi. Sonuç: Normal kilolu çoçuklara kıyasla kilolu çocuklarda SV diyastolik fonksiyonlarında azalma vardır. Kilolu çocuklarda BKİ, SV diyastolik fonksiyonlarında azalma ile ilişkilidir.Öğe Çocuklarda Obezitenin Sol Ventrikül Diyastolik Fonksiyonları Üzerine Etkisi(2013) Alpsoy, Şeref; Akyüz, Aydın; Akkoyun, Dursun Çayan; Nalbantoğlu, Burçin; Topçu, Birol; Değirmenci, Hasan; Donma, Mustafa MetinAmaç: Bu çalışmada obez ve normal kilolu çocuklarda iki boyutlu, M-Mod, geleneksel ve doku Doppler ekokardiyografi yle sol ventrikül diyastolik fonksiyon parametrelerini ölçmeyi ve bu parametreler üzerine antropometrik ve biyokimyasal faktörlerin etkilerini değerlendirmeyi amaçladık.Hastalar ve Yöntem: Bu olgu-kontrollü kesitsel çalışmaya, 8-15 yaş arası 60 obez ve 60 normal kilolu çocuk dahil edildi. Çocukların antropometrik ve biyokimyasal değerleriyle sol ventrikül ekokardiyografi k parametreleri ölçüldü ve aralarındaki ilişki araştırıldı.Bulgular: Obez grupta bel çevresi ve beden kitle indeksi (BKİ-Z) skoru, sistolik ve diyastolik kan basıncı, trigliserid, açlık kan şekeri, insülin ve homeostatik modeli değerlendirmesi (HOMD) indeksi anlamlı olarak yüksekken yüksek yoğunluklu lipoprotein kolesterol (YYL-K) konsantrasyonu anlamlı derecede düşük bulundu. Mitral annulus septal E' ve E'/A', mitral annulus lateral E' ve E'/A', anteriyor E' ve E'/A', inferiyor E' ve E'/A' değerleri anlamlı derecede düşük bulundu, mitral E'/septal E' ve mitral E/lateral E değerleri anlamlı olarak daha yüksekti. Çoğu doku Doppler parametreleri ile bel çevresi, BKİ-Z skoru, açlık kan şekeri, HOMD, serum insülin düzeyi sistolik ve diyastolik kan basıncı, trigliserid ve YYL-K arasında korelasyon vardı. Bel çevresi ve BKİ-Z skoru bazı doku Doppler parametreleri için belirleyiciydi.Sonuç: Obez çocuklarda akranlarına göre sol ventrikül diyastolik fonksiyonları bozulmuştur. Risk faktörleriyle diyastolik fonksiyon parametreleri arasında korelasyon olsa da, obezitenin kendisi sol ventrikül diyastolik fonksiyonlarında azalmayla ilişkilidir.
