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Öğe A Catatonic Schizophrenia Case Treated Effectively with Aripiprazole(Kure Iletisim Grubu A S, 2013) Albayrak, Yakup; Kuloğlu, MuratThe catatonic schizophrenia is an uncommon sub-type of schizophrenia, which demonstrates clinical signs such as catalepsy or stupor, posturing of voluntary movements, excessive negativism, mutism, mannerism, stereotypical movements such as echolalia and echopraxia. Atypical antipsychotics, benzodiazepines, ECT, and NMDA antagonists are reported to be effective in treatment of catatonic schizophrenia; however knowledge about the effective treatment of catatonic schizophrenia is still limited. In the present article, we have reported the case of a patient diagnosed with catatonic schizophrenia who was treated effectively with aripiprazole in a short period of time.Öğe A Report of Rabbit Syndrome Who Benefited from Sigma 1 Agonist Fluvoxamine(Korean Coll Neuropsychopharmacology, 2019) Albayrak, Yakup; Beyazyüz, Murat; Abbak, Özlem; Altındağ, EceRabbit Syndrome is an uncommon side effect of antipsychotic treatment. Although it is usually associated with typical antipsychotics, it can also be related to atypical antipsychotics. Anticholinergics are the most accepted treatment approach in treating Rabbit Syndrome. Fluvoxamine is a member of selective serotonin reuptake inhibitors and it is a potent agonist of sigma 1 receptors. In this article, we report a Rabbit Syndrome case who has benefited from fluvoxamine, in terms of both depressive disorder and Rabbit Syndrome; and present the data on the effects of sigma 1 agonist fluvoxamine on numerous movement disorders.Öğe Altered Affective Temperaments in Women With Vaginismus(NLM (Medline), 2021) Aksu, Erson; Beyazyüz, Elmas; Albayrak, Yakup; Potas, Nihan; Kumandaş, Gökçen; Bağ, İdil; Beyazyüz, MuratOBJECTIVE: Vaginismus is one of the most frequently occurring genito-pelvic pain disorders in women. Sexual dysfunction commonly presents with comorbid psychiatric disorders, and many patients suffering from the former exhibit the latter. The objective of this study was to investigate the affective temperaments of women with vaginismus compared to healthy controls. METHODS: Forty-eight women with vaginismus and 42 age-matched healthy women were recruited and compared in terms of their scores on the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire and a sociodemographic instrument. RESULTS: Except for the scores for hyperthymic temperament, those for depressive, cyclothymic, irritable, and anxious temperaments were significantly higher in the vaginismus group than in the healthy controls (P<.05). The analysis of covariance indicated that the anxious temperament was significantly associated with covariants. CONCLUSIONS: On the basis of the preliminary results, women with vaginismus may be candidates for bipolar disorder. This population should therefore be screened more carefully in terms of the development of the disorder. Bipolar disorder should also be considered when treatments for comorbid psychiatric disorders are needed. © Copyright 2021 Physicians Postgraduate Press, Inc.Öğe Altered cooperativeness in patients with polycystic ovary syndrome(Taylor and Francis Ltd., 2019) Aksu, Erson; Beyazyüz, Elmas; Albayrak, Yakup; Potas, Nihan; Durankuş, Ferit; Uvaçin, Gamze; Beyazyüz, MuratOBJECTIVE: In the present study, we aimed to compare temperament and character traits between patients with polycystic ovary syndrome (PCOS) and age-body mass index-matched healthy controls (HC). We hypothesized that patient with PCOS would differ in terms of temperament and character traits compared with HCs. MATERIAL AND METHODS: Fifty patients who were diagnosed with PCOS and 42 age-body mass index-matched healthy controls (HC) were included in the study. The groups were compared in terms of temperament and character traits and anxiety status with the Temperament and Character Inventory (TCI) and State-Trait Anxiety Inventory (STAI-1 and STAI-2). FINDINGS: There was a statistically significant difference between patient and the control group in terms of cooperativeness dimension (t = ?2.81; p = 0.006). It was a lower mean in the PCOS group (20.98 ± 2.992). In addition, scores of STAI-1 and STAI-2 were significantly higher in the PCOS group compared with the HC group (respectively; t = 5.70; p < 0.001; t = 2.12; p = 0.037). The score of cooperativeness and multivariate analysis of variance was found to be significantly lower in the PCOS group. CONCLUSIONS: Patients with PCOS had significant a different character trait such as lower cooperativeness compared with HC. Additionally, we found that this different character dimension would be a trait in PCOS after covariant analysis. We suggest that our result supported the psychiatric background of PCOS. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Öğe Altered methyltetrahydrofolate reductase gene polymorphism in mothers of children with attention deficit and hyperactivity disorder(Pergamon-Elsevier Science Ltd, 2019) Baykal, Saliha; Batar, Bahadır; Nalbantoğlu, Ayşin; Albayrak, Yakup; Hanci, Halil; Potas, Nihan; Karabekiroğlu, KorayAttention Deficit and Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders in childhood and causes significant functional impairments in children. Behavioral genetic and molecular genetic studies have provided significant evidence in terms of highlighting the etiology of ADHD. Folate deficiency during pregnancy is an established risk factor for ADHD. Polymorphisms in the Methyltetrahydrofolate Reductase (MTHFR) encoding gene, such as A1298C and C667T, are associated with the decreased bioavailability of folate, and this condition can act like folate deficiency. In the literature, no study has investigated MTHFR polymorphisms in mothers of children with ADHD. Sixty-four children diagnosed with ADHD and their mothers as well as 40 healthy children and their mothers participated in this study. MTHFR polymorphisms were investigated in all participants. Comparison of the C677C and A1298C MTHFR polymorphisms in children with and without ADHD revealed no significant differences. We found that the maternal C677C_CT genotype counts, both observed and expected values, were significantly different from those based on Hardy-Weinberg Principle Analysis in the ADHD group. The most important result of this study was that maternal C677C MTHFR gene polymorphisms are significant risk factors in for ADHD, and we argue that children with ADHD are exposed to folate deficiency, even if their mothers received a sufficient amount of folate during pregnancy. This result also highlights one of the genetic factors of ADHD. Further studies should be performed to confirm this finding.Öğe Altered Serum Chitotriosidase Activity and Irisin Level in Obese Children(2021) Durankus, Ferit; Şenkal, Evrim; Durankuş, Ramazan; Sünnetçi, Eda; Sayın, Oya; Potas, Nihan; Albayrak, YakupObjective:In this study, we aimed to investigate serum chitotriosidase (ChT) activity and irisin levels in children with obesity and compare them to those of healthy counterparts. Material and Methods: A total of 91 obese and 83 normal-weight children were included in the study. Serum ChT activity and irisin levels of children with obesity were compared to those of normal-weight children. Results: The mean ChT value in the obese group was 1825.332 ± 4804.147 nmol/L/h and was significantly higher than that in the control group. In contrast, the mean irisin level, 2679.663 ± 5473.58 pg/ml, was lower than that in the control group. The cutoff point of the continuous variable selected in the model for ChT was 601, with 31.9% sensitivity, 90.6% specificity, and an area under the curve of 0.596. The cutoff point for irisin was 901.4, with 83.5% sensitivity, 42.4% specificity, and an area under the curve of 0.617. Conclusion: This study is the first to show decreased serum both serum ChT activity and irisin level and ChT’s association with irisin levels in children with obesity . We argue that ChT and irisin should be considered potential biomarkers of metabolic syndrome in children with obesity.Öğe Altered thiol/disulfide homeostasis and ischemia-modified albumin levels in children with irritable bowel syndrome(John Wiley and Sons Inc, 2021) Durankuş, Ferit; Şenkal, E.; Çam, Sebahat; Potas, Nihan; Albayrak, Yakup; Nural, C.; Erel, ÖzcanBackground: In this study, we assessed thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with irritable bowel syndrome (IBS) compared with healthy children. Methods: Fifty-six children with IBS and 53 healthy children were included in the study after assessment of inclusion and exclusion criteria. Plasma thiol/disulfide and IMA levels were compared between children with and without IBS. Results: The mean values of native thiol, total thiol, and disulfide were 343.779 (Formula presented.) 138.654 ?mol/L, 365.398 ± 140.148 ?mol/L, and 23.190 ± 4.978 ?mol/L, respectively, in the IBS group and 409.908 ± 69.288 ?mol/L, 433.481 ± 76.891 ?mol/L, and 20.090 ± 4.252 ?mol/L, respectively, in the control group. Native thiol and total thiol values were significantly reduced in the IBS group compared with the control group. The mean IMA values were 0.835 ± 0.083 (g/L) and 0.778 ± 0.072 in the IBS and control groups, respectively. The IMA value was significantly increased in the IBS group. Conclusion: Impaired thiol/disulfide homeostasis and increased IMA levels can be considered etiological factors in children with IBS. © 2020 Japan Pediatric SocietyÖğe Antidepresanlar ve Akatizi(2013) Albayrak, Yakup; Kuloğlu, MuratAntidepresanlarla ilişkilendirilen başağrısı, bulantı veya kusma, ajitasyon, sedasyon, uykusuzluk ve cinsel işlev bozukluğu gibi yan etkiler iyi bilinmesine karşın antidepresanlar ve akatizi arasındaki ilişkiye dair bilgilerimiz sınırlıdır. Akatizi ciddi bir yan etkidir ve genellikle tipik antipsikotiklerin yan etkisi olarak kabul edilir. Akatiziyi fark etmek olası intihar girişimlerini önlemek açısından oldukça önemlidir. Bu yazıda akatizi hakkında genel bilgi vermeyi ve antidepresan tedaviyle olan ilişkisini gözden geçirmeyi amaçladık.Öğe Association between internalized stigma and some diagnostic subgroups, socio-demographic variables, and self-esteem levels in patients that refer to the psychiatry clinic of an education and research hospital(Istanbul Universitesi, 2015) Beyazyüz, Murat; Beyazyüz, Elmas; Albayrak, Yakup; Baykal, S.; Göka, E.Objective: This study was designed to investigate the associations between internalized stigma levels and socio-demographic variables, self-esteem levels, and some rigid bias in a patient sample which is divided into subgroups according to diagnostic categories of anxiety disorders, somatoform disorders and obsessive compulsive disorders. Methods: After an interview, socio-demographic data forms and illness data forms were filled in by the interviewer. Then Internalized Stigma of Mental Illness Scales and Rosenberg Self-esteem scales were given to patients to be filled in. Results: According to statistical analysis, higher internalized stigma levels were found in males, singles, rural habitants, and those who have not familial history of mental illness. In our study lower self-esteem was found to be negatively correlated with higher Discussion: Results of our study suggest that internalized stigma may influence the help-seeking behaviors and overall process of treatment, not only for patients with severe mental illnesses, but also for those who have mild or moderate mental disturbances. These diagnostic groups must be paid attention while executing studies against stigma and self-stigma. Otherwise, this kind of discrimination in anti-stigma campaigns may increase the stigmatization of mental illnesses. © 2015, Istanbul Universitesi. All rights reserved.Öğe Associations between treatment adherence and temperament and character traits in patients with bipolar disorder(Istanbul Universitesi, 2018) Gürsoy, M.S.; Abbak, Özlem; Beyazyüz, Murat; Albayrak, YakupObjective: Non-adherence to treatment in bipolar disorder can cause increased numbers of relapses and re-hospitalizations, severe impairment in functionality and increased risk of suicide attempts. Studies, investigated the associations between treatment adherence and temperament and character traits are limited in terms of quantity. In literature, there is only one study which researched relationships between affective temperament and treatment adherence in patients with bipolar disorder. Nevertheless, there is not any study which investigated associations between treatment adherence and temperament and character traits in bipolar disorder. In our study, it was aimed to investigate the associations between treatment adherence and temperament and character traits in patients with bipolar disorder. Method: Fifty-eight patients with a diagnosis of bipolar disorder were included into study. Patients were divided into three groups according to their level of adherence; high adherence, moderate adherence and low adherence according to Morisky Medication Adherence Scale. Temperament and character scores were compared between groups by temperament and character inventory. Results: After the comparison of all groups in terms of temperament traits, it was found that there was a significant difference between groups in terms of novelty seeking total score (F=4.12 p=0.03). Posthoc tests revealed that the low adherence group had significantly higher scores compared with other groups (p=0.04 ve p=0.03). There was a significant difference between groups in terms of scores of persistence (F= 5.79, p=0.04). Posthoc tests revealed that the low adherence group had significantly lower scores compared with other groups (respectively; p=0.02 ve p=0.04). Conclusion: Our study is the first in terms of investigating the associations between treatment adherence and temperament and character traits in patients with bipolar disorder. However further studies are needed which will confirm our findings. © 2018, Istanbul Universitesi. All rights reserved.Öğe Atorvastatin Improves the Propionic Acid- Induced Autism in Rats: The Roles of Sphingosine-1-Phosphate and Anti-inflammatory Action(Cureus Inc, 2023) Durankus, Ferit; Budak, Korkut; Albayrak, Yakup; Sever, Ibrahim H.; Ozkul, Bahattin; Uyanikgil, Yigit; Albayrak, NeslihanPurpose The aim of this study is to investigate the benefits of atorvastatin on the propionic acid-induced autism model via increasing sphingosine-1-phosphate and anti-inflammatory actions with imaging and brain tissue investigations. Materials and methods Twenty-five mg/kg/day/rat of propionic acid (PPA) was administered intraperitoneally to 20 male Wistar rats, and 10 male Wistar rats were fed orally. Study groups were designed as follows: Group 1: Control Group (orally fed control, n=10); Group 2 (PPA+saline, n=10); Group 3 (PPA+Atorvastatin, n=10). The brain biochemical and histopathology assessments and magnetic resonance (MR) imaging were conducted across groups in order to compare them. Results The PPA+Atorvastatin group was found to have significantly lower levels of brain malondialdehyde, IL -2 level, IL-17, tumor necrosis factor-alpha (TNF-??), and lactate compared to the PPA+saline group. The PPA+Atorvastatin group had higher levels of nerve growth factor and nuclear factor erythroid 2-related factor 2 (NRF-2) and sphingosine-1-phosphate. In histopathology assessments, the PPA+Atorvastatin group was found to have significantly higher neuronal counts of CA1 and CA2 in the hippocampus, and Purkinje cells in the cerebellum. Conclusions Current findings suggest that atorvastatin increases sphingosine-1-phosphate levels and decreases inflammatory actions which characterize the autism rodent model implemented in this study. These preliminary results have to be confirmed by further experimental and clinical studies.Öğe Author's Reply [2018](2018) Demirkıran, Aykut; Albayrak, Neslihan; Albayrak, Yakup; Zorkun, Cafer Sadık[No Abstract Available]Öğe Benefical Effects of Sigma-1 Agonist Fluvoxamine for Tardive Dyskinesia and Tardive Akathisia in Patients with Schizophrenia: Report of Three Cases(Korean Neuropsychiatric Assoc, 2013) Albayrak, Yakup; Hashimoto, KenjiFluvoxamine is a selective serotonin reuptake inhibitor that is approved for psychiatric disorders such as major depressive episodes and obsessive-compulsive disorder. Beside inhibition of serotonin reuptake, fluvoxamine is also a potent agonist of endoplasmic reticulum (ER) protein sigma-1 receptors, which play a role in the pathophysiology of a number of psychiatric and neurodegenerative disorders. This report presents beneficial effects of sigma-1 agonist fluvoxamine on hyperkinetic movement disorders such as tardive dyskinesia and tardive akathisia. Fluvoxamine might be a novel treatmet approach in the treatment of hyperkinetic movement disorders.Öğe Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion(Springer, 2020) Durankuş, Ferit; Şenkal, E.; Sünnetçi, E.; Albayrak, Yakup; Beyazyüz, Murat; Atasoy, Ö.; Erbaş, O.Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic. Although some studies have focused on the anti-inflammatory and anti-pyretic properties of ibuprofen during febrile convulsions, only one has investigated its antiepileptic effects. In the present study, we aimed to investigate the effects of ibuprofen in rats exposed to pentylenetetrazol (PTZ)-induced seizures. In total, 48 rats were randomly divided in two groups: Group A for electroencephalography (EEG) recordings and Group B for behavioral assessment. All EEG recordings and behavioral assessment protocols were performed. In addition, groups were compared in terms of prostaglandin F2 alfa (PGF2?) levels in the brain. We demonstrated the beneficial effects of the administration of ibuprofen in PTZ-induced seizures in rats via the following findings: spike percentages and Racine convulsion scale values were significantly lower and first myoclonic jerk (FMJ) onset times were significantly higher in the ibuprofen-administered groups. Moreover, PGF2? levels in the brain were significantly higher in the saline and PTZ 70 mg/kg group than in the control and PTZ 70 mg/kg and 400 mg/kg ibuprofen groups. Our study is the first to demonstrate the beneficial effects of ibuprofen on seizures through behavioral, EEG, and PGF2? brain assessments. Ibuprofen can be used for epilepsy and febrile seizures safely and without inducing seizures. However, further experimental and clinical studies are needed to confirm our results. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.Öğe Clinical implications of fluvoxamine and fluoxetine with sigma-1 receptor chaperone activity in the treatment of neuropsychiatric disorders(Nova Science Publishers, Inc., 2015) Albayrak, Yakup; Hashimoto, KenjiSelective serotonin reuptake inhibitors (SSRIs) are used as therapeutic drugs for a number of neuropsychiatric diseases throughout the world. Although all SSRIs act by blockading serotonin transporters, leading to elevated serotonin levels in the central nervous system (CNS), it is well known that their pharmacology is quite heterogeneous. Endoplasmic reticulum protein sigma-1 receptors represent a unique chaperone activity, and they exert a potent influence on a number of neurotransmitter systems. Accumulating evidence suggests that sigma-1 receptors play a role in the pathophysiology of neuropsychiatric and cardiovasular diseases, as well as in the mechanisms of some SSRIs. Among the SSRIs, the order of affinity for sigma-1 receptors is as follows: fluvoxamine > sertraline > fluoxetine > escitalopram > citalopram » paroxetine. In cell culture systems, some SSRIs (e.g., fluvoxamine, fluoxetine and escitalopram) potentiate nerve-growth factor (NGF)-induced neurite outgrowth in PC12 cells, and these effects can be antagonized by the selective sigma-1 receptor antagonist, NE-100. Furthermore, fluvoxamine, but not paroxetine or sertraline, improved phencyclidine-induced cognitive impairment in mice, and again, this effect could be antagonized by NE-100. Several clinical studies have found that fluvoxamine may offer beneficial effects in patients with neuropsychiatric disorders. In this chapter, the authors will discuss the role of sigma-1 receptors in the mechanistic action of some SSRIs and new clinical implications for SSRIs with potent sigma-1 receptor chaperone activity. © 2015 by Nova Science Publishers, Inc. All rights reserved.Öğe Comparison of Short Term Effects of Risperidone and Paliperidone on Serum Prolactin Levels in Female Patients(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2014) Albayrak, Yakup; Ünsal, Cüneyt; Beyazyüz, Murat; Kuloğlu, MuratObjective: Hyperprolactinemia is an adverse effect, which is related with the use of antipsychotics. All typical antipsychotics are considered to increase serum prolactin levels. Compared with typical antipsychotics, most of the atypical antipsychotics have a reduced tendency for increasing serum prolactin levels. However, effects of all atypical antipsychotics on serum prolactin levels are not always similar. In the present study, we aimed to compare short-term effects of risperidone and paliperidone, which are two similar atypical antipsychotics in terms of hyperprolactinemia and its associated symptoms. Methods: In this study, we screened data of female patients with diagnosis of schizophrenia and other psychotic disorders, bipolar disorder and who were treated with risperidone or paliperidone. The patients who had adequate sociodemographical and clinical data and who had screened in terms of prolactin levels before and fourth week of the treatment were included to study. Results: Forty-two patients have been treated with risperidone and 36 patients have been treated with paliperidone. Treatment groups were similar in terms of sociodemographic variables. The mean values of serum prolactin levels were significantly increased after four weeks of treatment in both groups (p<0.001). The discontinuation rates because of menstrual irregularities, galactorrhea, sexual dysfunction in risperidone and paliperidone groups were 11.9% and 30.6% respectively, and the rate was significantly higher in paliperidone group (chi(2) =4.13, p=0.04). Conclusion: We suggest that beside its benefits and some superiorities compared to risperidone, paliperidone has no advantage over risperidone in terms of hyperprolactinemia and its associated symptoms. We also suggest that female patients should be monitorized regulary in terms of hyperprolactinemia and its associated symptoms while they are being treated with paliperidone. To our knowledge, the present study is the first to compare and demonstrate the effects of paliperidone and risperidone on serum prolactin levels in Turkey. Further studies with larger sample size are needed to highlight the short term and long term effects of paliperidone on serum prolactin levels in female patients.Öğe Corpus callosum in schizophrenia with deficit and non-deficit syndrome: a statistical shape analysis(Bmj Publishing Group, 2021) Türk, Yaşar; Ercan, İlker; Şahin, İbrahim; Erdemli Gürsel, Başak; Uzunoğlu, Arda; Öğe, Cem; Beyazyüz, Elmas; Albayrak, YakupBackground The corpus callosum (CC) is the most targeted region in the cerebrum that integrates cognitive data between homologous areas in the right and left hemispheres. Aims Our study used statistical analysis to determine whether there was a correlation between shape changes in the CC in patients with schizophrenia (SZ) (deficit syndrome (DS) and non-deficit syndrome (NDS)) and healthy control (HC) subjects. Methods This study consisted of 27 HC subjects and 50 schizophrenic patients (20 with DS and 30 with NDS). 3 patients with DS and 4 patients with NDS were excluded. Three-dimensional, sagittal, T1-spoiled, gradient-echo imaging was used. Standard anatomical landmarks were selected and marked on each image using specific software. Results As to comparing the Procrustes mean shapes of the CC, statistically significant differences were observed between HC and SZ (DS+NDS) (p=0.017, James's F-j=73.732), HC and DS (p<0.001, James's F-j=140.843), HC and NDS (p=0.006, James's F-j=89.178) and also DS and NDS (p<0.001, James's F-j=152.967). Shape variability in the form of CC was 0.131, 0.085, 0.082 and 0.086 in the HC, SZ (DS+NDS), DS and NDS groups, respectively. Conclusions This study reveals callosal shape variations in patients with SZ and their DS and NDS subgroups that take into account the CC's topographic distribution.Öğe Crisis, crisophilia, and crisophilic(IGI Global, 2014) Beyazyüz, Murat; Erçetin, Sefika Sule; Albayrak, YakupToday it is not possible to talk about the concept of a crisis as comfortably as we speak of the word crisis because the word carries with it a serious semiologic problem. Alongside this, almost all situations described as a crisis carry a number of common features and the results arising from these features, though trivial, are still possible to discuss. In this chapter, after a brief review of the term crisis' academic language status, common psychological characteristics carried by the social systems in crisis situations arising from situations of weakness are addressed. In crisis situations, the available individuals', communities' or societies' self-defense and protection mechanisms indicate inability of the available methods to solve problems. Furthermore, Crisophilia can be found in all cases related to social systems and in all stages of crisis in your living area. In order to create living space, crisophilia applies actions aimed at creating the crisis itself. Crisophyilic individuals or groups wait patiently for the system to fall into a state of crisis and the intervention made during the crisis in the system is viewed as saving the system, due to this a crisophyilic individual or group can also sometimes be seen as a hero. Because of the desperation in the system a crisophyilic individual or group is adopted in the system. Here in this case, the system itself opens its doors to crisophyilia. © 2014 by IGI Global. All rights reserved.Öğe Decreased serum allopregnanolone and progesterone levels in male patients with bipolar disorder and their effects on cognitive functions(Springer Heidelberg, 2024) Karademir, Mihrali; Beyazyuz, Elmas; Beyazyuz, Murat; Yilmaz, Ahsen; Albayrak, YakupThe progression of bipolar disorder (BD) is characterized by recurrent episodes of depression, mania, and hypomania, thus affecting the daily functionality of individuals. Previous studies have shown that a large proportion of patients diagnosed with BD who are in clinical remission experience significant functional disorders. The present study aimed to investigate the relationships between cognitive impairment and serum progesterone, allopregnanolone and BDNF levels in male bipolar disorder patients who are in the euthymic period. Our study included 41 euthymic male patients with bipolar disorder and 40 age, sex, body mass index (BMI) and smoking-matched male healthy control subjects. Neuropsychiatric tests such as the Stroop Test TBAG Form, Auditory Verbal Digit Span Test- Form B (VADS-B) and Cancellation Test were administered to all participants, and 5-7 ml of peripheral venous blood sample was taken from all participants. Serum allopregnanolone, progesterone and BDNF levels were also measured in all participants. Serum allopregnanolone and progesterone levels were found to be lower in bipolar patients, and it was observed that the serum level of allopregnanolone decreased as the disease duration increased. The serum BDNF levels were similar between groups. The cognitive functions assessed using the Stroop, VADS-B and cancellation tests were found to be better in healthy subjects. The neurocognitive test performances of all participants were strongly positively correlated with allopregnanolone levels. The present study supports the hypothesis that allopregnanolone acts as an endogenous mood stabilizer.Öğe Decreased serum levels of brain-derived neurotrophic factor in schizophrenic patients with deficit syndrome(Dove Medical Press Ltd, 2015) Akyol, Esra Soydaş; Albayrak, Yakup; Beyazyüz, Murat; Aksoy, Nurkan; Kuloğlu, Murat; Hashimoto, KenjiBackground: Brain-derived neurotrophic factor (BDNF) is a well-established neurotrophin that plays a role in the pathophysiology of numerous psychiatric disorders. Many studies have investigated the serum BDNF levels in patients with schizophrenia. However, there are restricted data in the literature that compare the serum BDNF levels in patients with deficit and nondeficit syndromes. In this study, we aimed to compare the serum BDNF levels between schizophrenic patients with deficit or nondeficit syndrome and healthy controls. Methods: After fulfilling the inclusion and exclusion criteria, 58 patients with schizophrenia and 36 healthy controls were included in the study. The patients were grouped as deficit syndrome (N=23) and nondeficit syndrome (N=35) according to the Schedule for the Deficit Syndrome. Three groups were compared in terms of the sociodemographic and clinical variants and serum BDNF levels. Results: The groups were similar in terms of age, sex, body mass index, and smoking status. The serum BDNF levels in patients with deficit syndrome were significantly lower than those in healthy controls. In contrast, the serum BDNF levels in patients with nondeficit syndrome were similar to those in healthy controls. Conclusion: This study suggests that decreased BDNF levels may play a role in the pathophysiology of schizophrenic patients with deficit syndrome. Nonetheless, additional studies using a larger patient sample size are needed to investigate the serum BDNF levels in schizophrenic patients with deficit syndrome.
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