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    Cental Macular Thickness in Patients with Type 2 Diabetes Mellitus without Clinical Retinopathy
    (Hindawi Ltd, 2013) Demir, Mehmet; Dirim, Burcu; Acar, Zeynep; Yılmaz, Murat; Sendul, Yekta
    Objective. To compare central macular thickness (CMT) of diabetic patients with type 2 diabetes without clinical retinopathy and healthy subjects. Materials and Methods. Optical coherence tomography (OCT) measurements were performed in 124 eyes of 62 subjects with diabetes mellitus without clinical retinopathy (study group: 39 females, 23males; mean age: 55.06 +/- 9.77 years) and in 120 eyes of 60 healthy subjects (control group: 35 females, 25 males; mean age: 55.78 +/- 10.34 years). Blood biochemistry parameters were analyzed in all cases. The data for central macular thickness (at 1 mm), the levels of fasting plasma glucose, and glycosylated hemoglobin (HbA1c) were compared in both groups. Results. The mean central macular thickness was 232.12 +/- 24.41 mu m in the study group and 227.19 +/- 29.94 mu m in the control group. The mean HbA1c level was 8.92 +/- 2.58% in the study group and 5.07 +/- 0.70% in the control group (P = 0.001). No statistically significant relationship was found between CMT, HbA1c, and fasting plasma glucose level in either group (P > 0.05). Conclusions. Central macular thickness was not significantly thicker in patients with type 2 diabetes without clinical retinopathy than in healthy subjects.
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    Exposed Gamma Doses in air and Assessment of Cancer Risk around Gebze (Kocaeli/Turkey) Region
    (2021) Turgay, Muttalip Ergün; Acar, Zeynep; Yümün, Zeki Ünal; Artun, Arev; Kam, Erol
    By this study, it is focused to assessment of inhalation quality for Kocaeli province especially Northeast side of Marmara Sea (Gebze county and its territory). In this case, radioactivity analysis in air was realized via air dose rate measurements around this region which is so closed neighbor to big city Istanbul. By measuring of the outdoor gamma dose rates on 35 stations, it was possible to get the average dose rate. Then it was calculated to annual dose in air. Besides, cancer risk was determined for Kocaeli. All these values were compared with the World’s references (UNSCEAR) and reported finally. It was measured the average dose rate as 23.90 $nGyhr^{-1}$ and annual dose was calculated to 29.31 ?Sv. This dose is required to excess lifetime cancer risk as 1.02x$10^{?4}$ . These values could be compared to the similar studies which existed around the world. Finally, the average annual effective dose equivalent and excess lifetime cancer risk for Kocaeli, are less than the world average. This study would be used to a reference for further investigations, besides it will be usefull to compare with different studies for Kocaeli which, will be evaluated in the future, for example after a nuclear pollution, such as based on a reactor leakage comes from Black Sea region and neighbours, nuclear attacks, etc., too. Another benefit would be made to enlarge to find this kind of studies in literature.
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    Relationship between pruritus and autotaxin in intrahepatic cholestasis of pregnancy
    (Ediciones Doyma, S.L., 2021) Çifçi, S.; Irak, K.; Bayram, M.; Ekmen, Nergiz; Kazezoglu, C.; Acar, Zeynep; Sasani, Hadi
    Objective: Intrahepatic cholestasis of pregnancy is a temporary, pregnancy-specific disease that resolves with delivery, characterized by itching (pruritus), as well as high transaminase and serum bile acid levels in the third trimester of pregnancy. Due to the effects of Autotaxin on the physiology of pregnancy, we aimed to investigate Autotaxin activity in patients with intrahepatic cholestasis of pregnancy. Patients and methods: Sixty-nine patients diagnosed with intrahepatic cholestasis of pregnancy and 20 healthy pregnant women were enrolled in the study. Fasting serum bile acid, pruritus intensity, serum parameters, gestational week of the patients at the time of diagnosis were recorded, and birth week and birth weight were monitored. Autotaxin serum level was measured enzymatically. Results: The mean serum bile acid level (n = 69; 38.74 ± 35.92 ?mol/L) in patients with intrahepatic cholestasis of pregnancy (n = 69) was detected to be higher than healthy pregnant women (n = 20; 5.05 ± 1.88 ?mol/L) (p < 0.001). Weak correlation was detected between serum bile acid level and itch intensity (p = 0.014, r = 0.295), while no relation was detected between Autotaxin and itch intensity (p = 0.446, r = 0.09). Although mean Autotaxin (intrahepatic cholestasis of pregnancy: 678.10 ± 424.42 pg/mL, control: 535.16 ± 256.47 pg/mL) levels were high in patients with intrahepatic cholestasis of pregnancy, it was not statistically significant (p = 0.157). Conclusion: In our study, we observed that the serum Autotaxin level did not make a significant difference in patients with intrahepatic cholestasis of pregnancy compared to healthy pregnant women. These findings suggest that larger clinical studies are required to reveal the physio-pathological effects of Autotaxin on pregnancy. © 2020 Elsevier España, S.L.U.