dc.contributor.author | Alici, Özlem | |
dc.contributor.author | Kavaklı, Havva Sahin | |
dc.contributor.author | Koca, Cemile | |
dc.contributor.author | Altıntaş, Neriman Defne | |
dc.contributor.author | Aydın, Murat | |
dc.contributor.author | Alici, Süleyman | |
dc.date.accessioned | 2022-05-11T14:42:05Z | |
dc.date.available | 2022-05-11T14:42:05Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0962-9351 | |
dc.identifier.issn | 1466-1861 | |
dc.identifier.uri | https://doi.org/10.1155/2015/810948 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/9215 | |
dc.description.abstract | Background and Aim. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. Materials and Methods. Twenty-four rats were randomly divided into three experimental groups: sham (group 1), sepsis (group 2), and sepsis + CAPE (group 3), n = 8 each. CAPE was administered (10 mu mol/kg) intraperitoneally to group 3 before sepsis induction. Serum ET-1, serum TNF-alpha, tissue SOD activity, and tissue MDA levels were measured in all groups. Results. Pretreatment with CAPE decreased ET-1, TNFalpha, and MDA levels in sepsis induced rats. Additionally SOD activities were higher in rats pretreated with CAPE after sepsis induction. Conclusion. Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. Therefore treatment with CAPE can be used to avoid devastating effects of sepsis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Hindawi Ltd | en_US |
dc.identifier.doi | 10.1155/2015/810948 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Induced Lung Injury | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Superoxide-Dismutase | en_US |
dc.subject | Antioxidant Therapy | en_US |
dc.subject | Septic Shock | en_US |
dc.subject | Propolis | en_US |
dc.subject | Damage | en_US |
dc.subject | Cells | en_US |
dc.subject | Cape | en_US |
dc.subject | Mice | en_US |
dc.title | Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Mediators of Inflammation | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.identifier.volume | 2015 | en_US |
dc.institutionauthor | Aydın, Murat | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 23494580100 | |
dc.authorscopusid | 36617408300 | |
dc.authorscopusid | 15020620800 | |
dc.authorscopusid | 8440302700 | |
dc.authorscopusid | 7102765266 | |
dc.authorscopusid | 6701753460 | |
dc.identifier.wos | WOS:000353135000001 | en_US |
dc.identifier.scopus | 2-s2.0-84928485504 | en_US |
dc.identifier.pmid | 25948886 | en_US |