dc.contributor.author | Sıkar Aktürk, Aysun | |
dc.contributor.author | Güzel, Savaş | |
dc.contributor.author | Bulca, Songül | |
dc.contributor.author | Odyakmaz Demirsoy, Evren | |
dc.contributor.author | Bayramgürler, Dilek | |
dc.contributor.author | Bilen, Nilgün | |
dc.contributor.author | Kıran, Rebiay | |
dc.date.accessioned | 2022-05-11T14:42:05Z | |
dc.date.available | 2022-05-11T14:42:05Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0011-9059 | |
dc.identifier.issn | 1365-4632 | |
dc.identifier.uri | https://doi.org/10.1111/j.1365-4632.2012.05676.x | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/9208 | |
dc.description.abstract | Anecdotal reports suggest that using retinoids with vitamin E leads to improvements of some side effects due to isotretinoin. However, vitamin E blood levels have not been reported previously in patients with acne treated with isotretinoin. We aimed to investigate the serum vitamin E levels before and after isotretinoin therapy in patients with acne. A total of 70 patients treated with isotretinoin for acne in our dermatology department were included in this study. The serum vitamin E levels were measured as baseline before isotretinoin treatment. All patients received 0.60.8mg/kg/d isotretinoin. The treatment was finished within 57months while ensuring that the cumulative dose was 120mg/kg. Serum vitamin E levels were measured again in the last month of treatment. The mean serum vitamin E levels before and after treatment were compared. Forty-six patients completed the study. It was detected that the mean serum vitamin E level was 20.22mg/dl before isotretinoin treatment. In the last month of treatment, the mean serum vitamin E level was 16.24mg/dl. Serum vitamin E levels decreased in all patients except three. The mean serum vitamin E level after treatment was statistically decreased in comparison with the mean serum vitamin E level before treatment. Our results showed that vitamin E levels decreased during isotretinoin treatment. We considered that some of the side effects due to isotretinoin treatment might be related to this, and supplementation vitamin E may be useful during isotretinoin treatment. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.identifier.doi | 10.1111/j.1365-4632.2012.05676.x | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 13-Cis-Retinoic Acid | en_US |
dc.subject | Alpha-Tocopherol | en_US |
dc.subject | Dietary Levels | en_US |
dc.subject | Toxicity | en_US |
dc.subject | Skin | en_US |
dc.title | Effects of isotretinoin on serum vitamin E levels in patients with acne | en_US |
dc.type | article | en_US |
dc.relation.ispartof | International Journal of Dermatology | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-8120-9548 | |
dc.identifier.volume | 52 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 363 | en_US |
dc.identifier.endpage | 366 | en_US |
dc.institutionauthor | Güzel, Savaş | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 19933722100 | |
dc.authorscopusid | 23968920100 | |
dc.authorscopusid | 55598988000 | |
dc.authorscopusid | 37040438000 | |
dc.authorscopusid | 6603882748 | |
dc.authorscopusid | 6701389929 | |
dc.authorscopusid | 24779461500 | |
dc.authorwosid | bayramgürler, Dilek/AAD-1184-2020 | |
dc.authorwosid | Kiran, Rebiay/AAS-3065-2020 | |
dc.authorwosid | Demirsoy, Evren Odyakmaz/AAB-7136-2020 | |
dc.authorwosid | Aktürk, Aysun Şikar/AAS-3104-2020 | |
dc.identifier.wos | WOS:000315093700021 | en_US |
dc.identifier.scopus | 2-s2.0-84873974731 | en_US |
dc.identifier.pmid | 23414163 | en_US |