dc.contributor.author | Eraslan, Ersen | |
dc.contributor.author | Tanyeli, Ayhan | |
dc.contributor.author | Polat, Elif | |
dc.contributor.author | Polat, Elif | |
dc.date.accessioned | 2022-05-11T14:42:04Z | |
dc.date.available | 2022-05-11T14:42:04Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0021-9541 | |
dc.identifier.issn | 1097-4652 | |
dc.identifier.uri | https://doi.org/10.1002/jcp.27236 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/9200 | |
dc.description.abstract | The transient receptor potential melastatin-2 (TRPM2) channel belongs to the transient receptor potential channel superfamily and is a cation channel permeable to Na+ and Ca (2+). The TRPM2 ion channel is expressed in the kidney and can be activated by various molecules such as hydrogen peroxide, calcium, and cyclic adenosine diphosphate (ADP)-ribose (cADPR) that are produced during acute kidney injury. In this study, we investigated the role of 8-bromo-cyclic ADP-ribose (8-Br-cADPR; a cADPR antagonist) in renal ischemia-reperfusion injury using biochemical and histopathological parameters. CD38, cADPR, tumor necrosis factor-, interleukin-1, and myeloperoxidase (inflammatory markers), urea and creatinine, hydrogen peroxide (oxidant), and catalase (antioxidant enzyme) levels that increase with ischemia-reperfusion injury decreased in the groups treated with 8-Br-cADPR. In addition, renin levels were elevated in the groups treated with 8-Br-cADPR. Histopathological examination revealed that 8-Br-cADPR reduced renal damage and the expression of caspase-3 and TRPM2. Our results suggest that the inhibition of TRPM2 ion channel may be a new treatment modality for ischemic acute kidney injury. | en_US |
dc.description.sponsorship | Ataturk UniversitesiAtaturk University [2014-146] | en_US |
dc.description.sponsorship | Ataturk Universitesi, Grant/Award Number: 2014-146 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.identifier.doi | 10.1002/jcp.27236 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 8-Br-cADPR | en_US |
dc.subject | cytokines | en_US |
dc.subject | ischemia-reperfusion | en_US |
dc.subject | oxidative stress | en_US |
dc.subject | TRPM2 | en_US |
dc.subject | Cyclic-Adp-Ribose | en_US |
dc.subject | Intracellular Free Calcium | en_US |
dc.subject | Caspase-3 Gene-Expression | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Ischemia/Reperfusion Injury | en_US |
dc.subject | Ryanodine Receptor | en_US |
dc.subject | Molecular-Cloning | en_US |
dc.subject | Oxidant Stress | en_US |
dc.subject | Kidney Injury | en_US |
dc.subject | Mice Lacking | en_US |
dc.title | 8-Br-cADPR,a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Cellular Physiology | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-2424-2269 | |
dc.identifier.volume | 234 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 4572 | en_US |
dc.identifier.endpage | 4581 | en_US |
dc.institutionauthor | Polat, Elif | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57190794932 | |
dc.authorscopusid | 57191852988 | |
dc.authorscopusid | 56727936300 | |
dc.authorscopusid | 56727936300 | |
dc.authorwosid | Eraslan, Ersen/ABC-5840-2020 | |
dc.identifier.wos | WOS:000457613700118 | en_US |
dc.identifier.scopus | 2-s2.0-85052960369 | en_US |
dc.identifier.pmid | 30191993 | en_US |