dc.contributor.author | Utkan, Tijen | |
dc.contributor.author | Göçmez, Semil Selcen | |
dc.contributor.author | Regunathan, Soundararajan | |
dc.contributor.author | Arıcıoğlu, Feyza | |
dc.date.accessioned | 2022-05-11T14:41:09Z | |
dc.date.available | 2022-05-11T14:41:09Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0091-3057 | |
dc.identifier.uri | https://doi.org/10.1016/j.pbb.2012.07.003 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/9086 | |
dc.description.abstract | Agmatine (1-amino-4-guanidino-butane), a metabolite of L-arginine through the action of arginine decarboxylase, is a novel neurotransmitter. In the present study, effects of agmatine on cognitive functions have been evaluated by using one trial step-down passive avoidance and three panel runway task. Agmatine (20, 40, 80 mg/kg i.p.) was administered either in the presence or absence of a cholinergic antagonist, scopolamine (1 mg/kg i.p.). Scopolamine significantly impaired learning and memory in both passive avoidance and three panel runway test. Agmatine did not affect emotional learning, working and reference memory but significantly improved scopolamine-induced impairment of learning and memory in a dose dependent manner. Our results indicate that agmatine, as an endogenous substance, may have an important role in modulation of learning and memory functions. (c) 2012 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | Research Foundation of Kocaeli UniversityKocaeli University [200439] | en_US |
dc.description.sponsorship | The present study was supported by the Research Foundation of Kocaeli University (200439) and presented at Society of Biological Psychiatry's 65th Annual Meeting, New Orleans, Louisiana, 20-22 May, 2010. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Pergamon-Elsevier Science Ltd | en_US |
dc.identifier.doi | 10.1016/j.pbb.2012.07.003 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Agmatine | en_US |
dc.subject | Scopolamine | en_US |
dc.subject | Cognition | en_US |
dc.subject | Three panel runway | en_US |
dc.subject | Passive avoidance | en_US |
dc.subject | Nitric-Oxide Synthase | en_US |
dc.subject | Morphine-Withdrawal | en_US |
dc.subject | Cerebral-Ischemia | en_US |
dc.subject | Induced Seizures | en_US |
dc.subject | L-Citrulline | en_US |
dc.subject | Brain | en_US |
dc.subject | Involvement | en_US |
dc.subject | Modulation | en_US |
dc.subject | Glutamate | en_US |
dc.subject | Working | en_US |
dc.title | Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Pharmacology Biochemistry and Behavior | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-7341-4907 | |
dc.authorid | 0000-0001-5848-3680 | |
dc.identifier.volume | 102 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 578 | en_US |
dc.identifier.endpage | 584 | en_US |
dc.institutionauthor | Göçmez, Semil Selcen | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 7003362092 | |
dc.authorscopusid | 11440747800 | |
dc.authorscopusid | 10240709800 | |
dc.authorscopusid | 10638814800 | |
dc.authorwosid | ARICIOGLU, FEYZA/AAR-5704-2020 | |
dc.authorwosid | Aricioglu, Feyza/ABI-4003-2020 | |
dc.authorwosid | Utkan, Tijen/G-2398-2018 | |
dc.authorwosid | gocmez, semil selcen/G-2401-2018 | |
dc.identifier.wos | WOS:000308900200015 | en_US |
dc.identifier.scopus | 2-s2.0-84864502460 | en_US |
dc.identifier.pmid | 22796489 | en_US |