dc.contributor.author | Öztürk, İbrahim İsmet | |
dc.contributor.author | Banti, Christina N. | |
dc.contributor.author | Manos, Manos J. | |
dc.contributor.author | Tasiopoulos, Anastasios J. | |
dc.contributor.author | Kourkoumelis, Nikolaos | |
dc.contributor.author | Charalabopoulos, Konstantinos | |
dc.contributor.author | Hadjikakou, Sotiris K. | |
dc.date.accessioned | 2022-05-11T14:29:49Z | |
dc.date.available | 2022-05-11T14:29:49Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.issn | 1873-3344 | |
dc.identifier.uri | https://doi.org/10.1016/j.jinorgbio.2012.01.014 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/7141 | |
dc.description.abstract | Three new antimony(III) halide complexes (SbX3, X = Cl, Br and I) with the heterocyclic thione omega-thiocaprolactam (1-azacycloheptane-2-thione, (Hthcl)) of formulae {[SbCl2(mu(2)-Cl)(Hthcl)(2)](n)} (1), {[(SbBr2(mu(2)-Br)(Hthcl)(2))(2)]} (2) and {[(Sbl(2)(mu(2)-I)(Hthcl)(2))(2)]} (3) were synthesized from the reaction of antimony(III) halides with w-thiocaprolactam in 1:2 stoichiometry. The complexes were characterized by elemental analysis, FT-IR spectroscopy, H-1, C-13 NMR spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TG-DTA). Crystal structures of the ligand w-thiocaprolactam and its complexes 1-3 were determined with single crystal X-ray diffraction analysis. Complexes 1-3 and w-thiocaprolactam were evaluated for their in vitro cytotoxic activity against leiomyosarcoma (LMS) and human breast adenocarcinoma (MCF-7) tumor cell lines. Antimony complexes 1-3 exhibit strong antiproliferative activity against both cell lines tested. The higher such activity was found for 3 with IC50 values of 0.12 +/- 0.04 mu M (LMS) and 0.76 +/- 0.16 mu M (MCF-7) which are 60 and 10 times respectively, stronger than that of cisplatin. The influence of these complexes 1-3 and w-thiocaprolactam upon the catalytic peroxidation of linoleic acid to hyperoxolinoleic acid by the enzyme lipoxygenase (LOX) was kinetically and theoretically studied. The results were shown negligible inhibitory activity of 1-3 against LOX. (C) 2012 Elsevier Inc. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.identifier.doi | 10.1016/j.jinorgbio.2012.01.014 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Bioinorganic chemistry | en_US |
dc.subject | Antimony(III) halide complexes | en_US |
dc.subject | omega-Thiocaprolactam | en_US |
dc.subject | Crystal structures | en_US |
dc.subject | Cytotoxic activity | en_US |
dc.subject | Structural-Characterization | en_US |
dc.subject | Triphenylphosphine | en_US |
dc.subject | Thioamides | en_US |
dc.subject | Ligands | en_US |
dc.subject | Organotin(Iv) | en_US |
dc.subject | Lipoxygenase | en_US |
dc.subject | Oncology | en_US |
dc.subject | Thiones | en_US |
dc.subject | Acid | en_US |
dc.subject | Br | en_US |
dc.title | Synthesis, characterization and biological studies of new antimony(III) halide complexes with omega-thiocaprolactam | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Inorganic Biochemistry | en_US |
dc.department | Fakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.authorid | 0000-0003-3164-0038 | |
dc.authorid | 0000-0003-3264-2406 | |
dc.authorid | 0000-0001-7645-5560 | |
dc.authorid | 0000-0001-9556-6266 | |
dc.authorid | 0000-0002-4804-3822 | |
dc.authorid | 0000-0001-6727-2711 | |
dc.identifier.volume | 109 | en_US |
dc.identifier.startpage | 57 | en_US |
dc.identifier.endpage | 65 | en_US |
dc.institutionauthor | Öztürk, İbrahim İsmet | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 36785856200 | |
dc.authorscopusid | 46860923200 | |
dc.authorscopusid | 56884173600 | |
dc.authorscopusid | 6602706096 | |
dc.authorscopusid | 6507202525 | |
dc.authorscopusid | 7004310002 | |
dc.authorscopusid | 6602925165 | |
dc.authorwosid | Ozturk, Ibrahim Ismet/K-1352-2013 | |
dc.authorwosid | Manos, Emmanouil/F-8887-2012 | |
dc.authorwosid | Manos, Emmanouil/F-3442-2014 | |
dc.authorwosid | Kourkoumelis, Nikolaos/B-8555-2009 | |
dc.authorwosid | Hadjikakou, Sotiris K./I-2909-2019 | |
dc.identifier.wos | WOS:000303178200008 | en_US |
dc.identifier.scopus | 2-s2.0-84857388949 | en_US |
dc.identifier.pmid | 22377717 | en_US |