dc.contributor.author | Taşdelen, Betül | |
dc.contributor.author | Erdoğan, Sevil | |
dc.contributor.author | Bekar, Bahadır | |
dc.date.accessioned | 2022-05-11T14:16:05Z | |
dc.date.available | 2022-05-11T14:16:05Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2214-7853 | |
dc.identifier.uri | https://doi.org/10.1016/j.matpr.2018.05.043 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/6175 | |
dc.description | 14th International Conference on Nanosciences and Nanotechnologies (NN) -- JUL 04-07, 2017 -- Thessaloniki, GREECE | en_US |
dc.description.abstract | In this work, a new chitosan (CS)/hyaluronic acid (HA)/hydroxyapatite (HAP) hydrogels were synthesized by using gamma rays irradiation technique for oral delivery of drugs. The hydrogelss were characterized using fourier transform infrared spectroscopy (FTIR) and the physicochemical properties of shrimp chitosan was determined with both FTIR and scanning electron microscopy (SEM). The use of the hydrogel samples as a drug delivery system was investigated by an anticancer drug. 5-Fluorouracil (5-FU) was used as a model anticancer drug to investigate the drug uptake and release kinetics of hydrogels. The properties of the hydrogels were evaluated in terms of swelling, drug uptake and release behaviours. The addition of hyaluronic acid and hydroxyapatite in the gel structure improved drug uptake and release capability of the new hydrogels. (c) 2018 Elsevier Ltd. All rights reserved. Selection and/or Peer-review under responsibility of 14th International Conference on Nanosciences & Nanotechnologies (NN17). | en_US |
dc.description.sponsorship | Namik Kemal University Scientific Research ProjectNamik Kemal University [NKUBAP.00.17.AR.14.14] | en_US |
dc.description.sponsorship | The authors acknowledge Namik Kemal University Scientific Research Project (NKUBAP.00.17.AR.14.14) for funding. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Bv | en_US |
dc.identifier.doi | 10.1016/j.matpr.2018.05.043 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Hydrogels | en_US |
dc.subject | chitosan | en_US |
dc.subject | hyaluronic acid | en_US |
dc.subject | hydroxiapatite | en_US |
dc.subject | drug delivery | en_US |
dc.subject | Physicochemical Characterization | en_US |
dc.subject | Hydroxyapatite Nanoparticles | en_US |
dc.subject | Pharmaceutical Applications | en_US |
dc.subject | Chitosan | en_US |
dc.subject | Chitin | en_US |
dc.subject | Liver | en_US |
dc.title | Radiation synthesis and characterization of chitosan/hyraluronic acid/hydroxyapatite hydrogels: drug uptake and drug delivery systems | en_US |
dc.type | proceedingPaper | en_US |
dc.relation.ispartof | Materials Today-Proceedings | en_US |
dc.department | Fakülteler, Çorlu Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü | en_US |
dc.identifier.volume | 5 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 15990 | en_US |
dc.identifier.endpage | 15997 | en_US |
dc.institutionauthor | Taşdelen, Betül | |
dc.relation.publicationcategory | Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57189078413 | |
dc.authorscopusid | 55043447800 | |
dc.authorscopusid | 54584905800 | |
dc.authorwosid | Taşdelen, Betül/ABA-6295-2020 | |
dc.identifier.wos | WOS:000441006800006 | en_US |
dc.identifier.scopus | 2-s2.0-85056511434 | en_US |