dc.contributor.author | Nalbantoğlu, Ayşin | |
dc.contributor.author | Çelikkol, Aliye | |
dc.contributor.author | Samancı, Nedim | |
dc.contributor.author | Günaydın, Nurşen Ciğerci | |
dc.contributor.author | Nalbanto?lu, Burçin | |
dc.date.accessioned | 2022-05-11T14:14:03Z | |
dc.date.available | 2022-05-11T14:14:03Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0960-3271 | |
dc.identifier.issn | 1477-0903 | |
dc.identifier.uri | https://doi.org/10.1177/0960327120958105 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/5759 | |
dc.description.abstract | Aim: Bisphenol-A (BPA) is an endocrine disrupting compound and may exacerbate or induce allergic diseases. To the best of our knowledge, there is little evidence regarding the effects of BPA exposure on allergic rhinitis (AR) in children. In the present study, we sought to examine whether exposure to BPA in children is associated with AR. Methods: This study was designed as a case controlled clinical study. 140 children diagnosed as allergic rhinitis and 140 healthy children as control group were recruited. BPA, interleukin-4, interleukin-13, total IgE and interferon-gamma levels were determined. Skin prick tests were performed in patient group. Total nasal symptom score and ARIA classification were used to predict disease severity. Results: Serum IL-4, IgE and BPA levels of children with allergic rhinitis were found to be significantly higher than the control group. BPA and IL-4 levels were significantly higher in moderate to severe-persistent group. There was a positive correlation between total nasal symptom scores and Bisphenol A levels in children with allergic rhinitis. Conclusions: The present study is the first to observe statistically significant relationship between BPA concentrations and allergic rhinitis in children. Also increased levels of BPA are associated with disease severity. | en_US |
dc.description.sponsorship | Namik Kemal University Scientific Research Projects FundingNamik Kemal University [NKU.BAP.02, 18.159] | en_US |
dc.description.sponsorship | The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by Namik Kemal University Scientific Research Projects Funding [NKU.BAP.02.GA.18.159]. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sage Publications Ltd | en_US |
dc.identifier.doi | 10.1177/0960327120958105 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Endocrine disrupting chemicals | en_US |
dc.subject | rhinitis | en_US |
dc.subject | allergic | en_US |
dc.subject | child | en_US |
dc.subject | bisphenol A | en_US |
dc.subject | Exposure | en_US |
dc.subject | Diseases | en_US |
dc.title | Bisphenol A as a risk factor for allergic rhinitis in children | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Human & Experimental Toxicology | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-3799-4470 | |
dc.authorid | 0000-0002-5757-4051 | |
dc.identifier.volume | 40 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 395 | en_US |
dc.identifier.endpage | 402 | en_US |
dc.institutionauthor | Nalbantoğlu, Ayşin | |
dc.institutionauthor | Çelikkol, Aliye | |
dc.institutionauthor | Samancı, Nedim | |
dc.institutionauthor | Günaydın, Nurşen Ciğerci | |
dc.institutionauthor | Nalbanto?lu, Burçin | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 54791156900 | |
dc.authorscopusid | 57218879837 | |
dc.authorscopusid | 6603596874 | |
dc.authorscopusid | 57218876555 | |
dc.authorscopusid | 36165893600 | |
dc.authorwosid | ÇELIKKOL, ALIYE/ABE-2695-2020 | |
dc.identifier.wos | WOS:000568576800001 | en_US |
dc.identifier.scopus | 2-s2.0-85090567439 | en_US |
dc.identifier.pmid | 32909835 | en_US |