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dc.contributor.authorTülübaş, Feti
dc.contributor.authorGürel, Ahmet
dc.contributor.authorOran, Mustafa
dc.contributor.authorTopçu, Birol
dc.contributor.authorÇağlar, Veli
dc.contributor.authorUygur, Emine
dc.date.accessioned2022-05-11T14:07:37Z
dc.date.available2022-05-11T14:07:37Z
dc.date.issued2015
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.urihttps://doi.org/10.1177/0748233713483203
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5160
dc.description.abstractThis study aims to evaluate the protective effects of omega-3 fatty acids (FAs) on doxorubicin (DOX)-induced hepatotoxicity and nephrotoxicity in rats. A total of 24 adult male Sprague Dawley rats were divided into three groups. Control group was given only saline by intragastric gavage. DOX group received DOX at the dose of 30 mg/kg intraperitoneally on day 28. DOX-omega-3 FA group was given as omega-3 FAs at the dose of 400 mg/kg daily by intragastric gavage for 30 days and received DOX at the dose of 30 mg/kg intraperitoneally on day 28. At the end of the 30-day experimental period, the serum, liver and kidney tissue specimens were taken from the animals by giving a general anesthesia. Glutathione (GSH) and malondialdehyde (MDA) levels in serum and GSH and MDA levels and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in liver and kidney tissues were measured spectrophotometrically. In our study, a significant increase in MDA levels was observed in rats when given a dose of DOX and a significant decrease in the levels of GSH, SOD and GSH-Px activities in serum, liver and kidney tissues was determined when compared with control group. In addition, a significant decrease in MDA levels was observed in rats when a dose of omega-3 FAs was given with DOX and a significant increase was determined in the levels of GSH, SOD and GSH-Px activities in serum, liver and kidney tissues, when compared with DOX group. We concluded that omega-3 FA had favorable effects in rat liver and kidney tissues by preventing oxidative damage.en_US
dc.language.isoengen_US
dc.publisherSage Publications Incen_US
dc.identifier.doi10.1177/0748233713483203
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectoxidative stressen_US
dc.subjectomega-3 fatty acidsen_US
dc.subjectliveren_US
dc.subjectkidneyen_US
dc.subjectPolyunsaturated Fatty-Acidsen_US
dc.subjectInduced Oxidative Stressen_US
dc.subjectEicosapentaenoic Aciden_US
dc.subjectDocosahexaenoic Aciden_US
dc.subjectFish-Oilen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectVitamin-Een_US
dc.subjectToxicityen_US
dc.subjectImpacten_US
dc.subjectLiveren_US
dc.titleThe protective effects of omega-3 fatty acids on doxorubicin-induced hepatotoxicity and nephrotoxicity in ratsen_US
dc.typearticleen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalıen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalıen_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.identifier.volume31en_US
dc.identifier.issue7en_US
dc.identifier.startpage638en_US
dc.identifier.endpage644en_US
dc.institutionauthorTülübaş, Feti
dc.institutionauthorGürel, Ahmet
dc.institutionauthorOran, Mustafa
dc.institutionauthorTopçu, Birol
dc.institutionauthorÇağlar, Veli
dc.institutionauthorUygur, Emine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid8514414100
dc.authorscopusid36866111300
dc.authorscopusid55881189500
dc.authorscopusid37058172000
dc.authorscopusid25647609500
dc.authorscopusid55558318400
dc.authorwosidUYGUR, EMİNE/AAC-4470-2020
dc.identifier.wosWOS:000356981000009en_US
dc.identifier.scopus2-s2.0-84936966955en_US
dc.identifier.pmid23512535en_US


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