Comparison of Topical Treatment with Silver Sulfadiazine and Sweetgum Oil (Liquidambar orientalis) on Burn Wound Healing in an Experimental Rat Model
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info:eu-repo/semantics/closedAccessTarih
2016Yazar
Yanık, Mehmet EminUygur, Ramazan
Aktaş, Cevat
Emir, Seyfi
Kumral, Bahadır
Şener, Ümit
Kulaç, Mustafa
Erboğa, Mustafa
Uygur, Emine
Aydın, Murat
Yılmaz, Ahsen
Orhan, Abdullah Erkan
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OBJECTIVE: To investigate effects of Sweetgum oil (SO) on wound healing in comparison with silver sulfadiazine (SS) in a burn wound model, which was experimentally created on rats. It was observed in the literature that no study had investigated the effects of SO on burn wounds. STUDY DESIGN: Seventy-two Sprague Dawley rats were divided into 3 main groups: Burn, Burn+SS, and Burn+SO (subgroups: 4, 8, and 12 days). RESULTS: In the histopathological examinations it was observed that parameters indicating wound-healing stages had increased in the Burn+SS and Burn+SO groups more than in the Burn group, whereas they were similar in the Burn+SS and Burn+SO groups. In the PCNA immunostaining, more rapid epidermal growth, more increased thickening in the cuticular layer, and more prominent wound healing were observed in the Burn+SS and Burn+SO groups than in the Burn group. While hydroxyproline levels in the Burn+SS and Burn+SO subgroups were similar on Days 8 and 12, it was observed that levels were increased in the burn subgroups. CONCLUSION: Topical use of SO on burn wound areas had favorable effects on healing, indicating that this agent could be used as an alternative treatment for burn wounds.