PD-1 and PD-L2 expression predict relapse risk and poor survival in patients with stage III colorectal cancer
Özet
Background: Immune responses have long been an area of interest in cancer research. In this study, the effects of programmed cell death-1 (PD-1) and its ligand (PD-L2) on the prognosis of colorectal cancer (CRC) were investigated. Methods: Primary tumour specimens of stage III CRC patients operated between 2002 and 2013 were assessed for PD-1 and PD-L2 expression and various clinicopathological and prognostic factors. Results: We observed a significant relationship between poor prognostic factors and PD-1/PD-L2 expression. These biomarkers were also found to serve as independent risk factors for LIR and MSI. In univariate analysis, relapse-free survival (RFS) and overall survival (OS) rates were found to be poor in PD-1 and PD-L2 positive patients. In multivariate analysis, these biomarkers were found to serve as independent poor prognostic factors for RFS and OS. Conclusions: Our data indicate that PD-1 and PD-L2 may serve as independent prognostic survival parameters for CRC patients and may be employed for the design of targeted therapies. © 2021, Springer Nature Switzerland AG.
Cilt
44Sayı
2Koleksiyonlar
İlgili Öğeler
Başlık, yazar, küratör ve konuya göre gösterilen ilgili öğeler.
-
The role of primary tumor resection in patients with stage IV colorectal cancer with unresectable metastases
Urvay, Semiha; Eren, Tülay; Civelek, Burak; Kılıçkap, Sadettin; Yetişyiğit, Tarkan; Özaslan, Ersin (Zerbinis Publications, 2020)Purpose: Whether primary tumor resection (PTR) should be performed in patients with asymptomatic colorectal cancer (CRC) and unresectable synchronous metastasis is controversial. The purpose of this study was to investigate ... -
Evaluation of the relationship between serum ghrelin levels and cancer cachexia in patients with locally advanced nonsmall-cell lung cancer treated with chemoradiotherapy
Uysal, Pelin; Usul Afşar, Çiğdem; Sözer, Volkan; İnanç, Berrin; Ağaoğlu, Fulya; Güral, Zeynep; Uzun, Hafize; Fazlıoğlu, Nevin (Wolters Kluwer Medknow Publications, 2020)Background: Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the ... -
Use of Complementary Therapy in Lung Cancer Patients Treated with Chemotherapy and its Effect on Survival: A Cross-sectional Study
Çavdar, Eyyüp; Karaboyun, K.; İriağaç, Yakup; Avcı, Okan; Seber, Erdoğan Selçuk (Galenos Publishing House, 2023)Aim: Complementary therapies are being increasingly preferred in patients receiving anticancer therapy to strengthen the effect of chemotherapy and control cancer-related symptoms. In this study, we investigated the ...