dc.contributor.author | İzgi, S. | |
dc.contributor.author | Şengül, İbrahim Fazıl | |
dc.contributor.author | Şahin, E. | |
dc.contributor.author | Koca, M.S. | |
dc.contributor.author | Cebeci, F. | |
dc.contributor.author | Kandemir, Hakan | |
dc.date.accessioned | 2022-05-11T14:04:41Z | |
dc.date.available | 2022-05-11T14:04:41Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0022-2860 | |
dc.identifier.uri | https://doi.org/10.1016/j.molstruc.2021.131343 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/4710 | |
dc.description.abstract | In this current work, 7-azaindole based 1,3,4-oxadiazoles have been successfully prepared by treatment of 3-(hydrazonomethyl)-7-azaindole with the different acyl chlorides or acetic anhydrides to give the corresponding carbohydrazides, followed by iodine mediated synthetic protocol in order to afford the corresponding 2,5-disubstituted 1,3,4-oxadiazoles. The full characterization data of the novel compounds were obtained by utilizing 1H NMR, 13C NMR, FT-IR, high-resolution mass spectrometry and single crystal X-ray diffraction techniques. The antioxidant activity and ?-glucosidase inhibition potential of the prepared compounds are examined by in vitro assays. The targeted hydrazide linked 7-azaindoles and their corresponding cyclized form 1,3,4-oxadiazoles exhibited inhibitory potential with IC50 values ranges between 0.46 and 24.92 mM. Plausible binding mode and interaction of ligands with ?-glucosidase enzyme have been studied by molecular docking, supporting the experimental results. © 2021 Elsevier B.V. | en_US |
dc.description.sponsorship | 19.220, NKUBAP.01; Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK: 120Z116 | en_US |
dc.description.sponsorship | This work has been supported by The Scientific and Technological Research Council of Turkey (Project Number: 120Z116 ) and Tekirdag Namık Kemal University (Project Number: NKUBAP.01.GA.19.220 ). | en_US |
dc.description.sponsorship | This work has been supported by The Scientific and Technological Research Council of Turkey (Project Number: 120Z116) and Tekirdag Nam?k Kemal University (Project Number: NKUBAP.01.GA.19.220). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.identifier.doi | 10.1016/j.molstruc.2021.131343 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 1,3,4-oxadiazole | en_US |
dc.subject | 7-azaindole | en_US |
dc.subject | Antioxidant activity | en_US |
dc.subject | Docking study | en_US |
dc.subject | α-glucosidase inhibition | en_US |
dc.subject | Binding energy | en_US |
dc.subject | Chlorine compounds | en_US |
dc.subject | Mass spectrometry | en_US |
dc.subject | Single crystals | en_US |
dc.subject | 'current | en_US |
dc.subject | 1,3,4-oxadiazole | en_US |
dc.subject | 7-azaindole | en_US |
dc.subject | Antioxidant activities | en_US |
dc.subject | Carbohydrazide | en_US |
dc.subject | Docking studies | en_US |
dc.subject | Glucosidase | en_US |
dc.subject | Inhibition property | en_US |
dc.subject | Oxadiazoles | en_US |
dc.subject | ?-glucosidase inhibition | en_US |
dc.subject | Antioxidants | en_US |
dc.title | Synthesis of 7-azaindole based carbohydrazides and 1,3,4-oxadiazoles; Antioxidant activity, α-glucosidase inhibition properties and docking study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Molecular Structure | en_US |
dc.department | Fakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.identifier.volume | 1247 | en_US |
dc.institutionauthor | İzgi, S. | |
dc.institutionauthor | Kandemir, Hakan | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57240814700 | |
dc.authorscopusid | 55308985300 | |
dc.authorscopusid | 37098938400 | |
dc.authorscopusid | 56543023800 | |
dc.authorscopusid | 56572574200 | |
dc.authorscopusid | 55326408200 | |
dc.identifier.wos | WOS:000709586500009 | en_US |
dc.identifier.scopus | 2-s2.0-85114035627 | en_US |