Ara
Toplam kayıt 32, listelenen: 11-20
In vitro analysis of a novel controlled release system designed for intratympanic administration of N-acetylcysteine: a preliminary report
(W B Saunders Co-Elsevier Inc, 2015)
The aim of this in-vitro experimental study was to design a novel drug delivery system that may permit controlled release of N-acetylcysteine (NAC) following intratympanic administration. The system was composed of two ...
Toxicity of the acetyl-para-aminophenol group of medicines to intact intervertebral disc tissue cells
(Spandidos Publ Ltd, 2021)
The present study aimed to investigate the effects of paracetamol, an analgesic and antipyretic that is used in emergency departments and neurosurgery departments for postoperative pain management on intervertebral disc ...
Does Nimodipine, a Selective Calcium Channel Blocker, Impair Chondrocyte Proliferation or Damage Extracellular Matrix Structures?
(Bentham Science Publ Ltd, 2019)
Background: The study aimed to investigate the effects of the active ingredient, nimodipine, on chondrocyte proliferation and extracellular matrix (ECM) structures in cartilage tissue cells. Methods: Chondrocyte cultures ...
A Study of the Effects of Metformin, a Biguanide Derivative, on Annulus Fibrosus and Nucleus Pulposus Cells
(Turkish Neurosurgical Soc, 2020)
AIM: To investigate the effects of metformin, a drug used widely for the treatment of type 2 diabetes mellitus, on human primary cell cultures prepared from uninjured segment of disc material intervertebral disk tissues. ...
Delivering Growth Factors through a Polymeric Scaffold to Cell Cultures Containing both Nucleus Pulposus and Annulus Fibrosus
(Turkish Neurosurgical Soc, 2019)
AIM: To design a novel, polyvinyl alcohol (PVA)-based polymeric scaffold that permits the controlled release of insulin-like growth factor 1 (IGF-1)/bone morphogenetic protein (BMP)-2 following intervertebral disc ...
Investigation of the effect of dipyrone on cells isolated from intervertebral disc tissue
(Spandidos Publ Ltd, 2019)
The present study aimed to evaluate the effects of dipyrone, an indispensable analgesic, anti-pyretic and anti-spasmodic used in emergency departments, on nucleus pulposus and annulus fibrosus cells in vitro. After surgical ...
Are biological agents toxic to human chondrocytes and osteocytes?
(Bmc, 2015)
Purpose: The aim of the present study is to investigate the effects of biological agents (BAs) on human chondrocytes and osteocytes in vitro. Methods: Primary cell cultures obtained from gonarthrosis patients were divided ...
Evaluation of the effects of pregabalin on chondrocyte proliferation and CHAD, HIF-1 alpha, and COL2A1 gene expression
(Termedia Publishing House Ltd, 2018)
Introduction: The aim of the present study is to investigate the effects of pregabalin (PGB) on chondrocyte proliferation and collagen type II (COL2A1), hypoxia-inducible factor 1-alpha (HIF-1 alpha), and chondroadherin ...
Assessing the negative impact of phenyl alkanoic acid derivative, a frequently prescribed drug for the suppression of pain and inflammation, on the differentiation and proliferation of chondrocytes
(Bmc, 2016)
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed to relieve pain and inflammation. These NSAIDs have also analgesic effects and can be administered via oral, injectable, and topical ...
A practical way to prepare primer human chondrocyte culture
(Elsevier Science Bv, 2016)
Biological cartilage repair is one of themost important targets for orthopedic surgeons currently. For this purpose, it is mandatory to know how to prepare a chondrocyte culture. In this study, our purpose was to introduce ...