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An integrated and unifying hypothesis for the metabolic basis of sporadic Alzheimer's disease
(Ios Press, 2008)
Acquired disturbances of several aspects of cellular metabolism appear pathologically important in sporadic Alzheimer's disease (SAD). Among these, brain glucose utilization is reduced in the early stages of the disease. ...
Visceral adipose tissue specific persistence of Mycobacterium tuberculosis may be reason for the metabolic syndrome
(Churchill Livingstone, 2008)
Mycobacterium tuberculosis (Mtb) is highly successful intracellular pathogen. Infection is maintained in spite of acquired immunity and resists eradication by antimicrobials. Following bacillaemia, small numbers of bacteria ...
Unraveling the molecular mechanisms behind the metabolic basis of sporadic alzheimer's disease
(IOS Press, 2009)
Peripheral insulin resistance is associated with hyperinsulinemia, which may be associated with brain insulin deficiency that is characteristic of sporadic Alzheimer's disease (sAD). Oxidative insult, which is the result ...