dc.contributor.author | Seber, Erdoğan Selçuk | |
dc.contributor.author | İriağaç, Yakup | |
dc.contributor.author | Çavdar, Eyyüp | |
dc.contributor.author | Karaboyun, Kubilay | |
dc.contributor.author | Avcı, Okan | |
dc.contributor.author | Yolcu, Ahmet | |
dc.contributor.author | Gürdal, Sibel Özkan | |
dc.contributor.author | Öznur, Meltem | |
dc.date.accessioned | 2023-05-06T17:23:34Z | |
dc.date.available | 2023-05-06T17:23:34Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0104-4230 | |
dc.identifier.issn | 1806-9282 | |
dc.identifier.uri | https://doi.org/10.1590/1806-9282.20221255 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/12164 | |
dc.description.abstract | OBJECTIVE: The aim of this study was to investigate the predictive importance of the previously validated log(ER)*log(PgR)/Ki-67 predictive model in a larger patient population.METHODS: Patients with hormone receptor positive/HER-2 negative and clinical node positive before chemotherapy were included. Log(ER)*log(PgR)/ Ki-67 values of the patients were determined, and the ideal cutoff value was calculated using a receiver operating characteristic curve analysis. It was analyzed with a logistic regression model along with other clinical and pathological characteristics.RESULTS: A total of 181 patients were included in the study. The ideal cutoff value for pathological response was 0.12 (area under the curve=0.585, p=0.032). In the univariate analysis, no statistical correlation was observed between luminal subtype (p=0.294), histological type (p=0.238), clinical t-stage (p=0.927), progesterone receptor level (p=0.261), Ki-67 cutoff value (p=0.425), and pathological complete response. There was a positive relationship between numerical increase in age and residual disease. As the grade of the patients increased, the probability of residual disease decreased. Patients with log(ER)*log(PgR)/Ki-67 above 0.12 had an approximately threefold increased risk of residual disease when compared to patients with 0.12 and below (odds ratio: 3.17, 95% confidence interval: 1.48-6.75, p=0.003). When age, grade, and logarithmic formula were assessed together, the logarithmic formula maintained its statistical significance (odds ratio: 2.47, 95% confidence interval: 1.07-5.69, p=0.034).CONCLUSION: In hormone receptor-positive breast cancer patients receiving neoadjuvant chemotherapy, the logarithmic model has been shown in a larger patient population to be an inexpensive, easy, and rapidly applicable predictive marker that can be used to predict response. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Assoc Medica Brasileira | en_US |
dc.identifier.doi | 10.1590/1806-9282.20221255 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Patients | en_US |
dc.subject | Breast neoplasms | en_US |
dc.subject | Neoadjuvant therapy | en_US |
dc.subject | Antineoplastic agents | en_US |
dc.subject | Receptors | en_US |
dc.subject | progesterone | en_US |
dc.subject | estrogen | en_US |
dc.subject | Therapy | en_US |
dc.subject | Estrogen | en_US |
dc.subject | Subtypes | en_US |
dc.title | A logarithmic model for hormone receptor-positive and breast cancer patients treated with neoadjuvant chemotherapy | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Revista Da Associacao Medica Brasileira | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı | en_US |
dc.authorid | seber, selcuk erdogan/0000-0001-9081-2405 | |
dc.authorid | Cavdar, Eyyup/0000-0001-5885-3047 | |
dc.authorid | iriagac, Yakup/0000-0001-7411-1705 | |
dc.identifier.volume | 69 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 434 | en_US |
dc.identifier.endpage | 439 | en_US |
dc.institutionauthor | Seber, Erdoğan Selçuk | |
dc.institutionauthor | İriağaç, Yakup | |
dc.institutionauthor | Çavdar, Eyyüp | |
dc.institutionauthor | Karaboyun, Kubilay | |
dc.institutionauthor | Avcı, Okan | |
dc.institutionauthor | Yolcu, Ahmet | |
dc.institutionauthor | Gürdal, Sibel Özkan | |
dc.institutionauthor | Öznur, Meltem | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | seber, selcuk erdogan/H-3327-2017 | |
dc.identifier.wos | WOS:000954038500001 | en_US |
dc.identifier.scopus | 2-s2.0-85150316623 | en_US |
dc.identifier.pmid | 36921198 | en_US |