dc.contributor.author | Arslan, A.I. | |
dc.contributor.author | Karabağ, S. | |
dc.contributor.author | Akgül, Murat | |
dc.date.accessioned | 2023-04-20T08:04:16Z | |
dc.date.available | 2023-04-20T08:04:16Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0974-5130 | |
dc.identifier.uri | https://doi.org/10.4103/ijpm.ijpm_537_21 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/11060 | |
dc.description.abstract | Purpose: The present study aims to identify basaloid and luminal molecular groups and the p53-like sub-group, which is a sub-group of the luminal group, using a specific immunohistochemical panel and investigate human epithelial growth factor receptor 2 (HER2)/Neu and Fascin expression in these groups to analyze their relationship with clinicopathological features and prognosis in a cohort of cases with muscle-invasive urothelial bladder carcinoma (MIBC). Material and Methods: An immunohistochemical panel that included GATA-3, CK20, CD44, and CK5/6 was used to identify molecular sub-groups based on expression in 44 cases of MIBC. HER2/Neu and Fascin expression in basal, luminal, and p53-like groups and the relationship with clinicopathological features and prognosis were investigated. Results: The distribution of the molecular sub-groups determined by immunohistochemistry was as follows: 23 luminal cases (52.3%), 16 basal cases (36.4%), and 5 (11.4%) p53-like cases. There was a statistically significant difference in tumor size across the groups, with the greatest size in the p53-like group (p = 0.001). A statistically significant difference was observed in HER2/Neu expression between the molecular sub-groups (p = 0.017). Comparison of survival and HER2/Neu scores revealed shorter survival in patients with an HER2/Neu score of 3 + compared to those with scores of 0, 1+, and 2+ (p = 0.109). Fascin immunoreactivity was more common in the p53-like and basal groups compared to the luminal group (p = 0.036). Conclusion: Despite the limited number of cases in the MIBC group, our results support that HER2/Neu expression in the luminal sub-group and Fascin expression in basal and p53-like groups may be used as a negative prognostic marker. Multi-center studies that include large case series are warranted in this field. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | NLM (Medline) | en_US |
dc.identifier.doi | 10.4103/ijpm.ijpm_537_21 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Basal | en_US |
dc.subject | bladder cancer | en_US |
dc.subject | fascin | en_US |
dc.subject | HER2/Neu | en_US |
dc.subject | immunohistochemistry | en_US |
dc.subject | luminal | en_US |
dc.subject | p53-like | en_US |
dc.subject | actin binding protein | en_US |
dc.subject | carrier protein | en_US |
dc.subject | epidermal growth factor receptor 2 | en_US |
dc.subject | fascin | en_US |
dc.subject | protein p53 | en_US |
dc.subject | tumor marker | en_US |
dc.subject | bladder tumor | en_US |
dc.subject | breast tumor | en_US |
dc.subject | female | en_US |
dc.subject | genetics | en_US |
dc.subject | human | en_US |
dc.subject | metabolism | en_US |
dc.subject | muscle | en_US |
dc.subject | pathology | en_US |
dc.subject | phenotype | en_US |
dc.subject | prognosis | en_US |
dc.subject | Biomarkers, Tumor | en_US |
dc.subject | Breast Neoplasms | en_US |
dc.subject | Carrier Proteins | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Microfilament Proteins | en_US |
dc.subject | Muscles | en_US |
dc.subject | Phenotype | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Receptor, ErbB-2 | en_US |
dc.subject | Tumor Suppressor Protein p53 | en_US |
dc.subject | Urinary Bladder Neoplasms | en_US |
dc.title | Effect of HER2 and Fascin expression on muscle-invasive bladder cancers: Classification by basaloid and luminal phenotypes | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Indian journal of pathology & microbiology | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 65 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 604 | en_US |
dc.identifier.endpage | 609 | en_US |
dc.institutionauthor | Arslan, A.I. | |
dc.institutionauthor | Karabağ, S. | |
dc.institutionauthor | Akgül, Murat | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 57720962100 | |
dc.authorscopusid | 56904163300 | |
dc.authorscopusid | 57720994600 | |
dc.identifier.scopus | 2-s2.0-85135202946 | en_US |
dc.identifier.pmid | 35900488 | en_US |