Yazar "Yılmaz, İbrahim" için listeleme
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Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Yaman, Onur; Özbek, Hanefi; Ateş, Özkan (2020)AbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells ... -
Iopromide - and gadopentetic acid-derived preparates used in MR arthrography may be harmful to chondrocytes
Öznam, Kadir; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Kaya, Yasin Emre; İşyar, Mehmet; Gümüştaş, Seyit Ali; Mahiroğulları, Mahir (Bmc, 2017)Background: Magnetic resonance arthrography, a procedure through which contrast agents containing gadolinium and/or iopromide are administered intra-articularly, has become a useful tool in musculoskeletal diagnosis. ... -
Is Favipiravir a Potential Therapeutic Agent in the Treatment of Intervertebral Disc Degeneration by Suppressing Autophagy and Apoptosis?
Yılmaz, İbrahim; Akalan, Hande; Şirin, Duygu Yaşar; Karaarslan, Numan; Özbek, Hanefi; Ateş, Özkan (Turkish Neurosurgical Soc, 2022)AIM: To evaluate the effects of favipiravir (FVP) on cell viability and cytotoxicity in human degenerated primary intervertebral disc (IVD) tissue cell cultures. Furthermore, the protein expressions of hypoxia-inducible ... -
Is Implant Washing and Wound Irrigation with Rifampicin Effective for Preventing Surgical Site Infections in Lumbar Instrumentation?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Öznam, Kadir; Ateş, Özkan; Erdem, İlknur (Turkish Neurosurgical Soc, 2018)AIM: To determine whether the washing of implants and autogenous bone grafts with rifampicin, and the irrigation of the surgical field using diluted rifampicin, have any significant effect on the prevention of spinal implant ... -
Is it Possible to Treat Osteosarcoma Using Oligonucleotides Confined into Controlled Release Drug Delivery Systems?
Topuk, Savaş; Akyuva, Yener; Karaarslan, Numan; Mutlu, Çağrı A.; Yılmaz, İbrahim; İşyar, Mehmet; Mahiroğulları, Mahir (Bentham Science Publ Ltd, 2017)Purpose: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small ... -
İki Farklı Hastanenin Ortopedi Kliniklerinde Kullanılan Antibiyotik Seçeneklerinin Akılcı Antibiyotik Kullanımı Açısından Değerlendirilmesi
İşyar, Mehmet; Doğan, Mustafa; Gümüştaş, Seyit Ali; Yılmaz, İbrahim; Bilir, Bülent; Güler, Olcay; Mahiroğulları, Mahir; Saraçoğlu Varol, Gamze (2016)Amaç: Birbirine yakın ve aynı bölgede yer alan iki farklı hastanenin ortopedi ve travmatoloji servislerinde yatan hastalarda, etkeni saptanan enfeksiyon olgularında antibiyotik kullanımının, akılcı ilaç tedavi rehberleri ... -
A novel designed chitosan based hydrogelwhich is capable of consecutively controlled release of TGF-Beta 1 and BMP-7
Yılmaz, İbrahim; Gökay, Nevzat Selim; Gökçe, Alper; Tonbul, Murat; Gökçe, Çiğdem (Turkiye Klinikleri, 2013)Objective: Both Bone Morphogenetic Protein 7 (BMP-7) and Transforming Growth Factor Beta 1 (TGF-ß1) have stimulating effects on chondrocyte proliferation. These growth factors act at different time points of the biological ... -
Ortopedik Cerrah Tirotoksik Fırtınaya Yakalanmamak İçin Ne Yapmalı?
Bilir, Betül Ekiz; Bilir, Bülent; İşyar, Mehmet; Tonbul, Ayşe Tuba; Öznam, Kadir; Yılmaz, İbrahim; Çakmak, Selami (2016)Amaç: Non iyonik kontrast maddeler gibi iyot içeren preparatların kullanıldığı görüntüleme tetkiklerinde, kas protein yıkımına neden olan travmalarda, kosta kırıklarında, pürülan artrit gibi enfektif olgularda, kalça ... -
Pharmaco-molecular assessment of the effects of anandamide and its antagonists on hippocampal tissue in Wistar albino rats
Yılmaz, İbrahim; Karaarslan, Numan; Şirin, Duygu Yaşar; Özbek, Hanefi (Verduci Publisher, 2020)OBJECTIVE: The members of the matrix metalloproteinase (MMP) family and cannabinoids (CBs) are reportedly associated with hippocampus-dependent memory functions. However, the effects of endogenously formed CBs on hippocampal ... -
Practical Performance of Hippocampal Tissue Resection in Rats in Pharmacomolecular Research
Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi (Turkish Neurosurgical Soc, 2021)AIM: To explain how to resect hippocampal tissue in rats used as live mammalian subjects for the resection of fresh cerebral tissue in laboratories. MATERIAL and METHODS: Adult male Wistar-Albino rats (n=50) were used for ... -
A practical way to prepare primer human chondrocyte culture
İşyar, Mehmet; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Yalçın, Sercan; Güler, Olcay; Mahiroğulları, Mahir (Elsevier Science Bv, 2016)Biological cartilage repair is one of themost important targets for orthopedic surgeons currently. For this purpose, it is mandatory to know how to prepare a chondrocyte culture. In this study, our purpose was to introduce ... -
Pregabalin treatment for neuropathic pain may damage intervertebral disc tissue
Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Özbek, Hanefi; Kaplan, Necati; Kaya, Yasin Emre; Ateş, Özkan (Spandidos Publ Ltd, 2018)The aim of the present study was to determine whether pharmaceutical preparations with pregabalin (PGB) as an active ingredient, which are widely prescribed by clinicians, exert toxic effects on human primary nucleus ... -
A Rare Complication of Orbital Cellulitis in a Diabetic Case: Cavernous Sinus Thrombosis
Bilir, Betül Ekiz; Bilir, Bülent; Doğru, Mücahit; Polat, Evrim; Soysal Atile, Neslihan; Yılmaz, İbrahim (2016)Diyabetin çeşitli enfeksiyonlara ve tromboza eğilimi artırdığı iyi bilinmektedir. Diyabette doğal, hücresel ve humoral bağışıklık mekanizmalarının çeşitli basamaklarında bozukluklar beklenir. Trombosit fonksiyonlarındaki, ... -
Should the cardiac rhythm be monitored following administration of zoledronic acid in elderly osteoporotic women?
Yıldırım Güzelant, Aliye; Sarıfakıo?lu, Ayşe Banu; Yılmaz, İbrahim; Alpsoy, Şeref; Saraçoğlu Varol, Gamze; Taşdemir, Nicel (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2016)Objectives: This study aims to investigate the possible undesirable cardiac effects associated with zoledronic acid treatment in elderly osteoporotic women. Patients and methods: Between October 2010 and December 2013, a ... -
Sonographically Guided Corticosteroid Injection for Treatment of Plantar Fasciosis
Kayhan, Arda; Gökay, Nevzat Selim; Alpaslan, Rumeysa; Demirok, Mehmet; Yılmaz, İbrahim; Gökçe, Alper (Amer Inst Ultrasound Medicine, 2011)Objectives-The purpose of this study was to prospectively investigate the effect of sonographically guided corticosteroid injection on the clinical and radiologic responses in patients with proximal plantar fasciosis. ... -
Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler
Amaç: Bu çalışmada, dünya genelinde yapılan çalışmalariçerisinde, omurga patolojisinin giderilmesinde araştırılan,moleküler düzeyde gerçekleştirilen hücresel bazlı hedeftedavilerin, sistematik olarak incelenip, konu ... -
Spinopelvic Parameters in a Turkish Population: A Study on 120 Healthy Individuals that Could Facilitate Treatment Planning
Tonbul, Murat; Yıldırım Güzelant, Aliye; Gökçe, Alper; Gökay, Nevzat Selim; Yılmaz, İbrahim; Demirok, Mehmet (Ortadogu Ad Pres & Publ Co, 2012)Objective: To obtain data that could be beneficial for investigation of spine and pelvis parameters in a healthy Turkish population sample and planning surgery in patients who have spine deformities. Material and Methods: ... -
A Study of the Effects of Metformin, a Biguanide Derivative, on Annulus Fibrosus and Nucleus Pulposus Cells
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Şirin, Duygu Yaşar; Akalan, Hande; Özbek, Hanefi (Turkish Neurosurgical Soc, 2020)AIM: To investigate the effects of metformin, a drug used widely for the treatment of type 2 diabetes mellitus, on human primary cell cultures prepared from uninjured segment of disc material intervertebral disk tissues. ... -
A study on side effects of antibiotics used in the treatment of patients with head trauma and legal responsibility of clinicians in terms of the right to health
Karaarslan, Abdulkadir; Şimşek, Abdullah Talha; Doğan, Mustafa; Potoglu, Bilgehan; Yılmaz, İbrahim; Karaarslan, Numan (2019)Aim: Patients with head trauma are routinely, and commonly treated with prophylactic antibiotics, which may also be used for thetreatment of infection that may be developed during hospital stay. The relevant antibiotic ... -
A Study on the Effects of Direct Factor Xa Inhibitors and Direct Thrombin Inhibitors on Human Primary Chondrocyte Cultures
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Şirin, Duygu Yaşar; Özbek, Hanefi; Ateş, Özkan (2019)Aim:This study investigates the effects of two direct factor Xa inhibitors, apixaban and rivaroxaban, and a direct thrombin inhibitor, dabigatran, on human primary chondrocytecultures.Materials and Methods:Monolayer cultured ...