dc.contributor.author | Mutlu, Levent Cem | |
dc.contributor.author | Altıntaş, Nejat | |
dc.contributor.author | Aydın, Murat | |
dc.contributor.author | Tülübaş, Feti | |
dc.contributor.author | Oran, Mustafa | |
dc.contributor.author | Küçükyalçın, Volkan | |
dc.contributor.author | Kaplan, Gizem | |
dc.contributor.author | Gürel, Ahmet | |
dc.date.accessioned | 2022-05-11T14:42:05Z | |
dc.date.available | 2022-05-11T14:42:05Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0360-3997 | |
dc.identifier.issn | 1573-2576 | |
dc.identifier.uri | https://doi.org/10.1007/s10753-015-0158-5 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/9212 | |
dc.description.abstract | Exacerbations in chronic obstructive pulmonary disease (COPD) reduce quality of life and are associated with a more rapid deterioration of the disease. Growth differentiation factor-15 (GDF-15) is a novel candidate exacerbation biomarker. In this study, we aimed to assess GDF-15 as a biomarker of acute exacerbation of COPD (AE-COPD). Lung function parameters, arterial blood gas analysis, and circulating levels of GDF-15, C-reactive protein (CRP), and fibrinogen were assessed in 29 patients on admission to the hospital for AE-COPD, in 29 age-, gender-, and body mass index (BMI)-matched patients with stable COPD, and 29 matched controls with normal lung function. Patients with AE-COPD had higher circulating concentrations of GDF-15 (p < 0.001), CRP (p < 0.001), and fibrinogen (p < 0.002) compared with patients with stable COPD and healthy controls. GDF-15 levels correlated with systemic inflammatory marker CRP in patients with AE-COPD (r = 0.677, p < 0.001) and with stable COPD (r = 0.417, p = 0.024). Multivariate logistic regression analysis revealed GDF-15 (odds ratio 18.16, 95 % confidence interval (CI) 2.51-134.32; p = 0.005) as an independent predictor of AE-COPD. In receiver operating characteristic analysis, GDF-15 achieved an area under the curve of 0.78 for the identification of AE-COPD. In conclusion, GDF-15 is a novel blood biomarker of AE-COPD that is more sensitive than that of CRP. GDF-15 may offer new insights into the pathogenesis of AE-COPD. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer/Plenum Publishers | en_US |
dc.identifier.doi | 10.1007/s10753-015-0158-5 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | biomarker | en_US |
dc.subject | growth differentiation factor-15 | en_US |
dc.subject | chronic obstructive pulmonary disease | en_US |
dc.subject | inflammation | en_US |
dc.subject | Inflammatory Biomarkers | en_US |
dc.subject | Mortality | en_US |
dc.subject | Risk | en_US |
dc.subject | Copd | en_US |
dc.subject | Score | en_US |
dc.title | Growth Differentiation Factor-15 Is a Novel Biomarker Predicting Acute Exacerbation of Chronic Obstructive Pulmonary Disease | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Inflammation | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-3535-5704 | |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 1805 | en_US |
dc.identifier.endpage | 1813 | en_US |
dc.institutionauthor | Mutlu, Levent Cem | |
dc.institutionauthor | Altıntaş, Nejat | |
dc.institutionauthor | Aydın, Murat | |
dc.institutionauthor | Tülübaş, Feti | |
dc.institutionauthor | Oran, Mustafa | |
dc.institutionauthor | Küçükyalçın, Volkan | |
dc.institutionauthor | Kaplan, Gizem | |
dc.institutionauthor | Gürel, Ahmet | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 8531050000 | |
dc.authorscopusid | 54892706700 | |
dc.authorscopusid | 7102765266 | |
dc.authorscopusid | 8514414100 | |
dc.authorscopusid | 55881189500 | |
dc.authorscopusid | 56410921500 | |
dc.authorscopusid | 56577385000 | |
dc.authorwosid | Mutlu, Levent Cem/AAZ-5186-2020 | |
dc.identifier.wos | WOS:000360847200008 | en_US |
dc.identifier.scopus | 2-s2.0-84941167434 | en_US |
dc.identifier.pmid | 25820390 | en_US |