dc.contributor.author | Kanter, Mehmet | |
dc.contributor.author | Aktoz, Tevfik | |
dc.contributor.author | Aktaş, Cevat | |
dc.contributor.author | Özen, F. | |
dc.contributor.author | Yarali, O. | |
dc.contributor.author | Kanter, Betül | |
dc.date.accessioned | 2022-05-11T14:42:04Z | |
dc.date.available | 2022-05-11T14:42:04Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0884-6812 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/9197 | |
dc.description.abstract | OBJECTIVE: The aim of this study was to investigate the role of quercetin on cadmium-induced oxidative stress, testicular damage, and apoptosis in rat testes. STUDY DESIGN: The rats were randomly allotted into 1 of 3 experimental groups: control, cadmium-treated, and cadmium-treated with quercetin; each group contained 10 animals. Control animals received daily injections of the saline vehicle alone. The cadmium-treated group was injected subcutaneously with cadmium chloride (CdCl2) dissolved in saline at a dose of 2 mL/kg/ day for 30 days, resulting in a dosage of 1 mg/kg cadmium. The rats in quercetin-treated groups were given quercetin (15 mg/kg body weight) once a day i.p., starting 2 days prior to the cadmium injection during the study period. All animals were sacrificed and testes tissues were removed for histopathological and biochemical (malondialdehyde [MDA], superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], and serum testosterone levels) investigation. RESULTS: The mean seminiferous tubule diameter, Johnsen's mean testicular biopsy score values, biochemical parameters (MDA, SOD, GSH-Px, and serum testosterone levels), and amount of germ cell apoptosis were significantly decreased in the cadmium-treated groups as compared to the control group. Furthermore, the quercetin-treated animals showed improved histological and biochemical parameters in the cadmium-treated group. CONCLUSION: The present study showed that quercetin treatment protected testes against toxic effects of cadmium. We believe that further preclinical research into the utility of quercetin may indicate its usefulness as a potential treatment for spermatogenesis after testicular injury caused by cadmium-treated rats. © 2016 Science Printers and Publishers, Inc. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Science Printers and Publishers Inc. | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 3,3',4',5,7-Pentahydroxyflavone | en_US |
dc.subject | Antioxidants | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Cadmium | en_US |
dc.subject | Cadmium poisoning | en_US |
dc.subject | Oxygenradicals | en_US |
dc.subject | Quercetin | en_US |
dc.subject | Reactive oxygen species | en_US |
dc.subject | Testes | en_US |
dc.subject | Testicles | en_US |
dc.subject | Testis | en_US |
dc.subject | Testosterone | en_US |
dc.subject | cadmium chloride | en_US |
dc.subject | glutathione peroxidase | en_US |
dc.subject | malonaldehyde | en_US |
dc.subject | quercetin | en_US |
dc.subject | superoxide dismutase | en_US |
dc.subject | testosterone | en_US |
dc.subject | quercetin | en_US |
dc.subject | cadmium | en_US |
dc.subject | glutathione peroxidase | en_US |
dc.subject | malonaldehyde | en_US |
dc.subject | quercetin | en_US |
dc.subject | superoxide dismutase | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | animal tissue | en_US |
dc.subject | apoptosis | en_US |
dc.subject | Article | en_US |
dc.subject | biochemical analysis | en_US |
dc.subject | controlled study | en_US |
dc.subject | enzyme blood level | en_US |
dc.subject | germ cell | en_US |
dc.subject | histopathology | en_US |
dc.subject | male | en_US |
dc.subject | nonhuman | en_US |
dc.subject | oxidative stress | en_US |
dc.subject | priority journal | en_US |
dc.subject | rat | en_US |
dc.subject | seminiferous tubule | en_US |
dc.subject | testis biopsy | en_US |
dc.subject | testis injury | en_US |
dc.subject | testosterone blood level | en_US |
dc.subject | animal cell | en_US |
dc.subject | antioxidant activity | en_US |
dc.subject | enzyme activity | en_US |
dc.subject | spermatogenesis | en_US |
dc.subject | testis injury | en_US |
dc.subject | testis size | en_US |
dc.subject | animal | en_US |
dc.subject | apoptosis | en_US |
dc.subject | drug effects | en_US |
dc.subject | human | en_US |
dc.subject | metabolism | en_US |
dc.subject | oxidative stress | en_US |
dc.subject | pathology | en_US |
dc.subject | testis | en_US |
dc.subject | Animals | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Cadmium | en_US |
dc.subject | Glutathione Peroxidase | en_US |
dc.subject | Humans | en_US |
dc.subject | Male | en_US |
dc.subject | Malondialdehyde | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Quercetin | en_US |
dc.subject | Rats | en_US |
dc.subject | Seminiferous Tubules | en_US |
dc.subject | Superoxide Dismutase | en_US |
dc.subject | Testis | en_US |
dc.title | Role of quercetin in cadmium-induced oxidative stress, testicular damage, and apoptosis in rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Analytical and Quantitative Cytology and Histology | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 45 | en_US |
dc.identifier.endpage | 51 | en_US |
dc.institutionauthor | Aktaş, Cevat | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 7006356462 | |
dc.authorscopusid | 13609545500 | |
dc.authorscopusid | 24436194200 | |
dc.authorscopusid | 26646777500 | |
dc.authorscopusid | 56814931200 | |
dc.authorscopusid | 57006518400 | |
dc.identifier.scopus | 2-s2.0-84961864620 | en_US |
dc.identifier.pmid | 27363066 | en_US |