Assessment as both pathologic, clinicopathologic and immunohistochemical of pregnancy-associated breast carcinoma

Abstract

Introduction: Pregnancy-associated breast carcinoma (PABC) is stated as breast carcinoma (BC) diagnosed during pregnancy or within one or two years after delivery. It is rare during pregnancy. Materials and Methods: Thirteen cases of PABC occurring during the second and third trimester of pregnancy obtained from the computer database in hospital records during the year 2009/2016 are reported. The preparations stained with hematoxylin and eosin and stained as immunohistochemical for ER, PR, Ki-67 and HER2/neu expression were evaluated under light microscope. Discussion and Results: All patients were performed lumpectomy and sentinel lymphadenectomy. Surgical materials were sent to frozen. In the frozen study 4 patients (31%) who had not tumors in sentinel lymph node were not performed axillary lymphadenectomy. 9 patients (69%) who had tumors in sentinel lymph node were performed axillary lymphadenectomy and breast-conserving surgery. All patients were identified as invasive ductal carcinoma with pathologicaly examination. The patients ranged in age from 26 to 42 years (mean age 35 and median age 34 years). The diagnosis was made in 5 cases during pregnancy and in the other 8 cases during lactation. Maternal age during pregnancy was mean 36 years and median 35 years. 2 patients were diagnosed in the third trimester and 3 patient was diagnosed in the second trimester, with mean gestational ages of 24.2 weeks and median gestational ages of 22 weeks. Maternal age during lactation was mean 34.4 years and median 33.5 years. According to Modified Scarff-Bloom-Richardson System 8 patients (61.5%) during pregnancy and lactation were grade 2 and 5 patients (38.5%) were grade 3. At presentation, 7 patients (54%) were classified as having American Joint Committee on Cancer clinical Stage II disease, 6 (46%) were classified as having Stage III disease in all patients. Conclusion: Late diagnosis of PABC in which advanced the stage of the disease is confirmed by my observation.