dc.contributor.author | Karaarslan, Numan | |
dc.contributor.author | Gürbüz, Mehmet Sabri | |
dc.contributor.author | Çalışkan, Tezcan | |
dc.contributor.author | Ayan, Erdoğan | |
dc.contributor.author | Vardar Aker, Fugen | |
dc.contributor.author | Berkman, Mehmet Zafer | |
dc.date.accessioned | 2022-05-11T14:34:46Z | |
dc.date.available | 2022-05-11T14:34:46Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1019-5149 | |
dc.identifier.uri | https://doi.org/10.5137/1019-5149.JTN.12807-14.1 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/8089 | |
dc.description.abstract | AIM: To analyse the effect of MMP-3 (Matrix Metalloproteinase Enzyme-3)-one of the extracellular matrix proteins-on the prognosis and biological behaviour of meningiomas. MATERIAL and METHODS: 79 cases of meningioma that were operated in our clinic between 2005 and 2010 were retrospectively analysed. Age, sex, preoperative peritumoral edema, histological subtype, grade, Ki-67 expression, MMP-3 staining pattern and recurrence rate were analysed. Pathological preparations were graded according to the WHO (World Health Organisation) 2007 grading system. RESULTS: Of the MMP-III positive cases; 24 cases (60%) were grade I, 16 cases were grade II. The MMP-3 staining pattern was significantly positive (80%) in grade II meningioma. 14 of the MMP-3 positive cases were atypical meningiomas. Of the 20 cases with high Ki-67 proliferation index (PI), 12 cases (60%) were MMP-3 positive and 8 cases (40%) were MMP-3 negative. Rates of recurrence and preoperative peritumoral edema were high in cases with MMP-3 positivity. CONCLUSION: In this study it was determined that MMP-3 positivity has a strong relationship with meningiomas having an aggressive character. MMP-3 may be used as a proliferation marker for biological behaviour, recurrence rate and prognosis of meningiomas. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Turkish Neurosurgical Soc | en_US |
dc.identifier.doi | 10.5137/1019-5149.JTN.12807-14.1 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Grade | en_US |
dc.subject | Ki-67 Proliferation index | en_US |
dc.subject | Matrix Metalloproteinase-3 | en_US |
dc.subject | Meningioma | en_US |
dc.subject | Expression | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Ki-67 | en_US |
dc.subject | Angiogenesis | en_US |
dc.subject | Recurrence | en_US |
dc.subject | Target | en_US |
dc.subject | Roles | en_US |
dc.subject | Mmp-9 | en_US |
dc.title | The Effect of Matrix Metalloproteinase-3 on the Prognosis and Biological Behaviour of Meningiomas | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Turkish Neurosurgery | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-5590-0637 | |
dc.identifier.volume | 26 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 678 | en_US |
dc.identifier.endpage | 683 | en_US |
dc.institutionauthor | Karaarslan, Numan | |
dc.institutionauthor | Çalışkan, Tezcan | |
dc.institutionauthor | Ayan, Erdoğan | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 56674583800 | |
dc.authorscopusid | 55372092900 | |
dc.authorscopusid | 56674439000 | |
dc.authorscopusid | 55967340100 | |
dc.authorscopusid | 6603952159 | |
dc.authorscopusid | 7006006212 | |
dc.authorwosid | KARAARSLAN, Numan/I-6819-2019 | |
dc.identifier.wos | WOS:000385338600004 | en_US |
dc.identifier.scopus | 2-s2.0-85017078100 | en_US |
dc.identifier.pmid | 27438616 | en_US |