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dc.contributor.authorŞabudak, Temine
dc.contributor.authorÖztürk, Mehmet
dc.contributor.authorAlpay, Enes
dc.date.accessioned2022-05-11T14:30:57Z
dc.date.available2022-05-11T14:30:57Z
dc.date.issued2017
dc.identifier.issn1307-6167
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7249
dc.description.abstractTwo new biflavonoids, (8-hydroxy-3'-beta-D-galactosyl-isoflavone)-2'-8'''-(4'''-hydroxy-flavone)biflavone (2); 2', 3', 5-trihydroxy-5 ''-methoxy-3 ''-O-a-glucosyl-3-4'''-O-biflavone (3) and along with apigenin (1) and quercetin-3-O-beta-glucoside (4) were isolated by activity guided fractionation from the whole plant of Solanum nigrum L.. The structures were established on the basis of UV, IR, 1D, 2D NMR and HRESI-MS spectroscopic methods. The anticholinesterase activity was performed against acetylcholinesterase and butyrylcholinesterase - the chief enzymes of Alzheimers' disease - using the Ellman method. The tyrosinase inhibitory activity was performed according to L-DOPA method. Since the ethyl acetate (IC50: 90.6+/-0.3 mu g/mL) and n-butanol (IC50: 140.6+/-1.7 mu g/mL) extracts exhibited good butyrylcholinesterase inhibitory activity, both were fractionated and the active fractions were used for isolation of the compounds. These both extracts were also exhibited better tyrosinase inhibitory activity (IC50: 76.0+/-0.6, and 156.8+/-1.9 mu g/mL, respectively). Tested enzyme inhibitory activities of S. nigrum were presented in this study for the first time.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK-TBAG-113Z552x]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey through the project (TUBITAK-TBAG-113Z552).en_US
dc.language.isoengen_US
dc.publisherAcg Publicationsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSolanum nigrumen_US
dc.subjectanticholinesterase activityen_US
dc.subjecttyrosinase inhibitory activityen_US
dc.subjectbiflavonoiden_US
dc.subjectFruit Extracten_US
dc.subjectWater Extracten_US
dc.subjectAntioxidanten_US
dc.subjectCellsen_US
dc.subjectApoptosisen_US
dc.subjectAutophagyen_US
dc.subjectInductionen_US
dc.subjectHepg2en_US
dc.subjectLinnen_US
dc.titleNew Bioflavonoids from Solanum nigrum L. by Anticholinesterase and Anti-tyrosinase Activities-guided Fractionationen_US
dc.typearticleen_US
dc.relation.ispartofRecords of Natural Productsen_US
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.authorid0000-0001-8932-4535
dc.authorid0000-0003-4384-4265
dc.identifier.volume11en_US
dc.identifier.issue2en_US
dc.identifier.startpage130en_US
dc.identifier.endpage140en_US
dc.institutionauthorŞabudak, Temine
dc.institutionauthorAlpay, Enes
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid6505866652
dc.authorscopusid7102665882
dc.authorscopusid57192684349
dc.authorwosidÖztürk, Mehmet/W-4649-2017
dc.authorwosidSABUDAK, Temine/AAG-6784-2019
dc.identifier.wosWOS:000398611100003en_US
dc.identifier.scopus2-s2.0-85007302690en_US


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