dc.contributor.author | Karasakal, Ayça | |
dc.contributor.author | Ulu, Sevgi Tatar | |
dc.date.accessioned | 2022-05-11T14:29:53Z | |
dc.date.available | 2022-05-11T14:29:53Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1522-7235 | |
dc.identifier.issn | 1522-7243 | |
dc.identifier.uri | https://doi.org/10.1002/bio.2541 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/7166 | |
dc.description.abstract | A selective and sensitive spectrofluorimetric method was developed and validated for the determination of amoxapine in human plasma and urine. The developed method is based on labeling with 5-dimethylaminonaphthalene-1-sulfonyl chloride (dansyl chloride) and monitoring at 397nm (excitation)/514nm (emission). The method was validated for linearity, limit of detection (LOD), limit of quantification (LOQ), precision, accuracy, recovery and robustness. The calibration curves were linear over a concentration range of 250-2500 and 50-1250ng/mL for plasma and urine, respectively. The LOD values were calculated to be 13.31 and 13.17ng/mL for plasma and urine, respectively. The proposed method was applied to study of amoxapine in human plasma and urine. Copyright (c) 2013 John Wiley & Sons, Ltd. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.identifier.doi | 10.1002/bio.2541 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | derivatization | en_US |
dc.subject | spectrofluorimetry | en_US |
dc.subject | plasma | en_US |
dc.subject | urine | en_US |
dc.subject | validation | en_US |
dc.subject | dansyl chloride | en_US |
dc.subject | Performance Liquid-Chromatography | en_US |
dc.subject | Tricyclic Antidepressants | en_US |
dc.subject | Whole-Blood | en_US |
dc.subject | Metabolites | en_US |
dc.subject | Chloride | en_US |
dc.subject | Serum | en_US |
dc.title | Development and validation of a sensitive spectrofluorimetric method for the determination of amoxapine in human plasma and urine | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Luminescence | en_US |
dc.department | Fakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü | en_US |
dc.authorid | 0000-0003-2759-4411 | |
dc.identifier.volume | 29 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 284 | en_US |
dc.identifier.endpage | 287 | en_US |
dc.institutionauthor | Karasakal, Ayça | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 55235059200 | |
dc.authorscopusid | 34574169900 | |
dc.authorwosid | karasakal, ayca/ABA-4762-2020 | |
dc.identifier.wos | WOS:000334346000013 | en_US |
dc.identifier.scopus | 2-s2.0-84898785782 | en_US |
dc.identifier.pmid | 23780763 | en_US |