dc.contributor.author | Durankuş, Ferit | |
dc.contributor.author | Şenkal, E. | |
dc.contributor.author | Çam, Sebahat | |
dc.contributor.author | Potas, Nihan | |
dc.contributor.author | Albayrak, Yakup | |
dc.contributor.author | Nural, C. | |
dc.contributor.author | Erel, Özcan | |
dc.date.accessioned | 2022-05-11T14:05:08Z | |
dc.date.available | 2022-05-11T14:05:08Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1328-8067 | |
dc.identifier.uri | https://doi.org/10.1111/ped.14406 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11776/4905 | |
dc.description.abstract | Background: In this study, we assessed thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with irritable bowel syndrome (IBS) compared with healthy children. Methods: Fifty-six children with IBS and 53 healthy children were included in the study after assessment of inclusion and exclusion criteria. Plasma thiol/disulfide and IMA levels were compared between children with and without IBS. Results: The mean values of native thiol, total thiol, and disulfide were 343.779 (Formula presented.) 138.654 ?mol/L, 365.398 ± 140.148 ?mol/L, and 23.190 ± 4.978 ?mol/L, respectively, in the IBS group and 409.908 ± 69.288 ?mol/L, 433.481 ± 76.891 ?mol/L, and 20.090 ± 4.252 ?mol/L, respectively, in the control group. Native thiol and total thiol values were significantly reduced in the IBS group compared with the control group. The mean IMA values were 0.835 ± 0.083 (g/L) and 0.778 ± 0.072 in the IBS and control groups, respectively. The IMA value was significantly increased in the IBS group. Conclusion: Impaired thiol/disulfide homeostasis and increased IMA levels can be considered etiological factors in children with IBS. © 2020 Japan Pediatric Society | en_US |
dc.language.iso | eng | en_US |
dc.publisher | John Wiley and Sons Inc | en_US |
dc.identifier.doi | 10.1111/ped.14406 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | irritable bowel syndrome | en_US |
dc.subject | oxidative stress | en_US |
dc.subject | thiol | en_US |
dc.subject | disulfide | en_US |
dc.subject | ischemia modified albumin | en_US |
dc.subject | thiol | en_US |
dc.subject | biological marker | en_US |
dc.subject | disulfide | en_US |
dc.subject | human serum albumin | en_US |
dc.subject | ischemia-modified albumin | en_US |
dc.subject | serum albumin | en_US |
dc.subject | thiol derivative | en_US |
dc.subject | adolescent | en_US |
dc.subject | albumin blood level | en_US |
dc.subject | Article | en_US |
dc.subject | blood level | en_US |
dc.subject | constipation | en_US |
dc.subject | controlled study | en_US |
dc.subject | diarrhea | en_US |
dc.subject | female | en_US |
dc.subject | homeostasis | en_US |
dc.subject | human | en_US |
dc.subject | irritable colon | en_US |
dc.subject | major clinical study | en_US |
dc.subject | male | en_US |
dc.subject | oxidative stress | en_US |
dc.subject | pathogenesis | en_US |
dc.subject | child | en_US |
dc.subject | homeostasis | en_US |
dc.subject | irritable colon | en_US |
dc.subject | metabolism | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Child | en_US |
dc.subject | Disulfides | en_US |
dc.subject | Homeostasis | en_US |
dc.subject | Humans | en_US |
dc.subject | Irritable Bowel Syndrome | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Serum Albumin | en_US |
dc.subject | Serum Albumin, Human | en_US |
dc.subject | Sulfhydryl Compounds | en_US |
dc.title | Altered thiol/disulfide homeostasis and ischemia-modified albumin levels in children with irritable bowel syndrome | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Pediatrics International | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 63 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 300 | en_US |
dc.identifier.endpage | 305 | en_US |
dc.institutionauthor | Albayrak, Yakup | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 55315126400 | |
dc.authorscopusid | 55175886400 | |
dc.authorscopusid | 8240771400 | |
dc.authorscopusid | 36523620300 | |
dc.authorscopusid | 29067508300 | |
dc.authorscopusid | 57195410600 | |
dc.authorscopusid | 7003566828 | |
dc.identifier.wos | WOS:000629305300001 | en_US |
dc.identifier.scopus | 2-s2.0-85102500015 | en_US |
dc.identifier.pmid | 32713058 | en_US |