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dc.contributor.authorErkal, Tuba Ozge Yasar
dc.contributor.authorKılıç, Servet
dc.contributor.authorHatipoğlu, Fatih
dc.contributor.authorTerzi, Funda
dc.date.accessioned2022-05-11T14:42:13Z
dc.date.available2022-05-11T14:42:13Z
dc.date.issued2019
dc.identifier.issn0367-6722
dc.identifier.urihttps://doi.org/10.18805/ijar.B-924
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9290
dc.description.abstractClinical effects and pathological changes of synthetic oligodeoxynucleotide (ODN), prednol (PRD) and azathioprine (AZA) was compared on uveitis treatment in rats. A total of 28 Wistar Albino, female, adult rats were divided into Control (C), PRD, AZA and ODN groups. Uveitis was induced by 176 mu g/rat subcutan injection E. coli, LPS and observed in all animals after 48 hours. Then, 0.25 mg/rat/day AZA and 1.25 mg/rat/day of methylprenidolone was administered by gavage in AZA and PRD groups for ten days. In the ODN group, 178 mu g/rat ODN was administered IP totally four times. A numerical weight loss was seen in all groups in the course of the infection period, but dropped dramatically in the PRD group during the treatment period. Average value of right and left eye results showed that immunesuppressive effect of Prednol was higher in terms of IOP values compared to others whereas Shirmer test values were the lowest in the post-treatment period. Finally, Prednol was more effective with its immunesuppressive effect resulting in recovery of photophobia, vascularization and oedema in iris vessels.en_US
dc.description.sponsorshipScientific Projects Research Commision of Namik Kemal University [NKUBAP.10, 16.019]en_US
dc.description.sponsorshipThis study was supported by the Scientific Projects Research Commision of Namik Kemal University (Project no: NKUBAP.10.GA.16.019).en_US
dc.language.isoengen_US
dc.publisherAgricultural Research Communication Centreen_US
dc.identifier.doi10.18805/ijar.B-924
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAzathioprineen_US
dc.subjectODNen_US
dc.subjectPrednolen_US
dc.subjectRaten_US
dc.subjectUveitisen_US
dc.subjectPreventionen_US
dc.subjectModelsen_US
dc.titleComparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in ratsen_US
dc.typearticleen_US
dc.relation.ispartofIndian Journal of Animal Researchen_US
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Bilimler Bölümü, Cerrahi Ana Bilim Dalıen_US
dc.authorid0000-0002-0103-5868
dc.identifier.volume53en_US
dc.identifier.issue6en_US
dc.identifier.startpage827en_US
dc.identifier.endpage831en_US
dc.institutionauthorErkal, Tuba Ozge Yasar
dc.institutionauthorKılıç, Servet
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57297089700
dc.authorscopusid57296022200
dc.authorscopusid6602521213
dc.authorscopusid57196002965
dc.authorwosidKilic, Servet/ABA-3409-2020
dc.authorwosidHatipoglu, Fatih/M-8076-2014
dc.identifier.wosWOS:000472915800023en_US
dc.identifier.scopus2-s2.0-85117124323en_US


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