No Relationship Between 25 Oh Vitamin D and Autoimmunity in Women Patients with Hypothyroidism

Abstract

Introduction: Hypothyroidism is a common disease in the society. Based on the effects of vitamin D on immune system and endocrine system, the relationship between hypothyroidism and vitamin D gained importance. The relationship between vitamin D deficiency and thyroid was suggested for the first time by Kivity and his colleagues. In their study, they found a significant relationship between thyroid autoantibodies and vitamin D levels. In this study we want to show the relationship between autoimmunity and vitamin D deficiency in female patients with hypothyroidism. Materials and methods: This study was performed at the GOP Taksim Education and Research Hospital outpatient department of internal medicine between January and June in 2015. It included 80 females patients, and 18 control females subjects Results: A total of 98 participants were included in this study. The mean durations of hypothyroidism are 5,86 +/- 5,91 vs. 5,43 +/- 5,62 years. Anti-thyroid autoantibodies (Anti TPO) and anti-thyroglobulin antibodies (anti TG) levels were significantly higher in the group 1 patients compared to the group 2 patients and control subjects (p<0,01). There were no significant differences at other variables between the patients and control subjects. The serum 25-OH vitamin D levels were significantly lower in the Hashimoto thyroiditis and Non-Hashimoto thyroiditis patients compared to the healthy controls (10,88 +/- 9,19 ng/ml vs. 10,53 +/- 6,87 ng/ml, p<0.01). Conclusion: It was thought that the study's being conducted during the winter months might have affected vitamin D levels. The vitamin D value of the control group cases was found to be higher as compared to the case of hypothyroidism associated with Hashimoto's thyroiditis and of hypothyroidism associated with other reasons. No significant difference was observed in vitamin D levels between the groups of hypothyroidism associated with Hashimoto's thyroiditis and hypothyroidism associated with other reasons